Results 91 to 100 of about 783,269 (286)

Biochemical properties of Paracoccus denitrificans FnrP:Reactions with molecular oxygen and nitric oxide [PDF]

, 2016
In Paracoccus denitrificans, three CRP/FNR family regulatory proteins, NarR, NnrR and FnrP, control the switch between aerobic and anaerobic (denitrification) respiration.
A Volbeda, A Yan, AJ Jervis, Andrew J. Thomson, AS Fleischhacker, B Weiss, B Zhang, CP Tseng, CT Przysiecki, CV Popescu, D Ralt, DJ Richardson, DJ Shaw, DM Bates, F Sievers, G Sawers, H Beinert, H Reents, J Crack, J Edwards, J Green, Jason C. Crack, JC Crack, JC Crack, JC Crack, JC Crack, JC Crack, JC Crack, JC Crack, JC Crack, JC Crack, JC Drapier, L Bergaust, LJ Moore, LR Bakken, M Matsui, Matthew I. Hutchings, MC Broillet, MF Otten, MI Hutchings, MI Hutchings, MM Bradford, N Filenko, Nick E. Le Brun, NJ Watmough, P Bouchal, PJ Kiley, R Bruckdorfer, R Veldman, RJ Spanning Van, RJ Spanning van, SA Ibrahim, SB Melville, ST Pullan, VR Sutton, WG Zumft, YM Kwon, YY Lee   +57 more
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

J integral computation and limit load analysis of bonded composite repair in cracked pipes under pressure

Fracture and Structural Integrity, 2019
In this paper an additional criterion was introduced to evaluate the composite repair systems using the limit load analysis. The plastic collapse pressure of API 5L X65 PSL2 steel pressure vessel structure with crack defect is numerically investigated ...
M. Belhamiani, D. E. Belhadri, W. Oudad, O. Mansouri, W. N. Bouzitouna   +4 more
doaj   +1 more source

Finite element analyses of fatigue crack growth under small scale yielding conditions modelled with a cyclic cohesive zone approach [PDF]

, 2013
Mode I fatigue crack growth is modelled and investigated with a cohesive zone approach. A 2D finite element boundary layer model under plane strain and small scale yielding conditions is used to generate fatigue crack growth rate curves ...
Kuna, Meinhard, Roth, Stephan
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Modeling of a cracked and repaired Al 2024T3 aircraft plate: effect of the composite patch shape on the repair performance

Fracture and Structural Integrity, 2019
In this work the finite element method was used to analyse the composite patch shape effect of the repair performance. Unlike all the works done conducted so far in this domain, this work proposed here, takes into account the reducing both, the stress ...
Baghdadi Mohammed, Serier Boualem, Salem Mokadem, Zaoui Bouchra, Kaddouri Khacem   +4 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The influence of cracks on the corrosion initiation time caused by chloride diffusion in concrete structures using the Boundary Element Method [PDF]

Revista IBRACON de Estruturas e Materiais
Reinforced concrete structures in coastal zones are subject to corrosion triggered by chloride ions. In contact with the concrete surface, such ions penetrate through the material’s porous microstructure, mainly by diffusion, and accumulate on the ...
Vinícius de Barros Souza, Edson Denner Leonel   +1 more
doaj   +1 more source