Results 111 to 120 of about 781,009 (287)

Analisa Kegagalan pada Fuel Intake Manifold Pesawat Terbang Boeing 737-500

Jurnal Teknik ITS, 2013
Fuel intake manifold merupakan komponen yang sangat penting di pesawat terbang dimana fuel intake manifold berfungsi sebagai penyalur bahan bakar yang akan dibawa ke engine.
Jeffri Malau, Rochman Rochiem
doaj  

Crack Front Waves and the dynamics of a rapidly moving crack

, 2001
Crack front waves are localized waves that propagate along the leading edge of a crack. They are generated by the interaction of a crack with a localized material inhomogeneity.
A. B. Movchan, A. Tsirk, B. Q. Vu, E. Bouchaud, E. K. Beauchamp, E. Sharon, E. Sharon, E. Sharon, E. Sharon, E. Sharon, G. Cohen, G. Perrin, H. Bergkvist, J. D. Eshelby, J. F. Boudet, J. F. Boudet, J. Fineberg, J. Fineberg, J. Fineberg, J. R. Rice, J. R. Rice, J. R. Willis, J. R. Willis, J. W. Morrissey, J. W. Morrissey, K. J. Maloy, L. B. Freund, S. Ramanathan, T. Cramer, Y. Ben-Zion   +29 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Size scaling of strength in thin film delamination

, 2011
We investigate by numerical simulation the system size dependence of the shear delamination strength of thin elastic films. The films are connected to a rigid substrate by a disordered interface containing a pre-existing crack. The size dependence of the
Alava M J, Bazant Z P, M Zaiser, Zaiser M, Zaiser M   +4 more
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

The importance of geomechanics in oil and gas geology and in the processes of opening producing horizons

Мінеральні ресурси України, 2017
The role of geomechanical factors is shown by the specific examples, particularly the type of stress-strain state (SSS) of rocks on the formation of geological structures with the characteristics of reservoirs or lids, and also technogenic cracks around ...
Yu. I. Voitenko
doaj  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Language, listening and learning:critically reflective accountability for INGOs [PDF]

, 2013
Crack, Angela Maria
core   +1 more source