Results 121 to 130 of about 783,269 (286)
Language, listening and learning:critically reflective accountability for INGOs [PDF]
, 2013 Crack, Angela Maria
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Self-healing of Micro-cracks in Engineered Cementitious Composites
Civil Engineering Dimension, 2015 The performance of an Engineered Cementitious Composite (ECC) to self-heal micro-cracks under a controlled laboratory environment is presented. Ten dog-bone shaped samples were prepared; five of them were preloaded to known strains and then left to heal
Suryanto B., Wilson S.A., McCarter W.J.
doaj
Reversing the telescope:evaluating NGO peer regulation initiatives [PDF]
, 2016 Crack, Angela
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A nonlocal elasticity theory to model the static behaviour of edge-cracked nanobeams
Fracture and Structural IntegrityIn the present paper, the mechanical behaviour of edge-cracked nanobeams under Mixed-Mode loading is analytically investigated by means of the Stress-Driven nonlocal model. Firstly, the proposed formulation is outlined, and then applied to the case of a
Daniela Scorza +5 more
doaj +1 more source
The regulation of international NGOs:assessing the effectiveness of INGO Accountability Charter [PDF]
, 2018 Crack, Angela
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
ON CRACK CLOSURE IN FATIGUE CRACK GROWTH
, 1978 A brief review of the various forms of closure is given, and the relative importance of plasticity-induced closure and roughness-induced closure is considered. On the basis of the lack of a thickness effect and an insensitivity to R in the absence of closure it is concluded that plasticity-induced closure plays a relatively minor role in affecting the ...
openaire +2 more sources