Results 81 to 90 of about 781,009 (287)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
As Estratégias de Coping para o Manejo da Fissura de Dependentes de Crack
Clinical and Biomedical Research, 2010 Objetivo: Analisar as estratégias de coping para o manejo da fissura em dependentes de crack internados para desintoxicação. Método: Estudo transversal com amostra composta por 35 sujeitos dependentes de crack pela CID-10, do sexo masculino, internados ...
Renata Brasil Araujo +3 more
doaj
O crack em um cenário empedrado: articulações entre os discursos jurídico, médico e midiático
Psicologia & Sociedade, 2014 O artigo aborda o surgimento do crack nas metrópoles brasileiras, o grande internamento de seus usuários na última década e a leitura midiática sobre o tema.
Mateus Freitas Cunda +1 more
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Iterated Brownian motion in an open set [PDF]
, 2004 Suppose a solid has a crack filled with a gas. If the crack reaches the surrounding medium, how long does it take the gas to diffuse out of the crack? Iterated Brownian motion serves as a model for diffusion in a crack.
DeBlassie, R. Dante
core +4 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Frontiers in Built Environment, 2020 Although many models for service life predictions have been developed, their application to existing bridges is still not at a satisfactory level. The here presented coupled three-dimensional chemo-hygro-thermo-mechanical (CHTM) model can realistically ...
Marija Kušter Marić +5 more
doaj +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
An investigation of irregular crack path effects on fracture mechanics parameters using a grain microstructure meshing technique [PDF]
, 2012 Electronic version of an article published as Journal of Multiscale Modeling, Vol. 4, Iss. 1, atricle 1250001, 2012, http://dx.doi.org/10.1142/S1756973712500011 © World Scientific Publishing Company, http://www.worldscientific.com/worldscinet/jmmA sub ...
Biglari, F. +3 more
core +1 more source