Results 81 to 90 of about 783,269 (286)

A finite element strategy coupling a gradient-enhanced damage model and cohesive cracks for quasi-brittle materials [PDF]

, 2013
A new combined strategy to describe failure of quasi-brittle materials is presented thus allowing the complete description of the process, from initiation of damage to crack propagation.
Rodríguez Ferran, Antonio, Tamayo-Mas, Elena   +1 more
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Chloride Transport in Cracked Concrete Subjected to Wetting – Drying Cycles: Numerical Simulations and Measurements on Bridges Exposed to De-Icing Salts

Frontiers in Built Environment, 2020
Although many models for service life predictions have been developed, their application to existing bridges is still not at a satisfactory level. The here presented coupled three-dimensional chemo-hygro-thermo-mechanical (CHTM) model can realistically ...
Marija Kušter Marić, Joško Ožbolt, Joško Ožbolt, Gojko Balabanić, Olesya Zhychkovska, Serena Gambarelli   +5 more
doaj   +1 more source

Fatigue crack growth in thin notched woven glass composites under tensile loading. Part I: experimental [PDF]

, 2011
Helicopter blades are made of composite materials mainly loaded in fatigue and have normally relatively thin skins. A through-the-thickness crack could appear in these skins.
Barrau, Jean-Jacques, Bizeul, Matthieu, Bouvet, Christophe, Cuenca, Rémy   +3 more
core   +3 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Fatigue crack propagation in microcapsule toughened epoxy [PDF]

, 2004
The addition of liquid-filled urea-formaldehyde (UF) microcapsules to an epoxy matrix leads to significant reduction in fatigue crack growth rate and corresponding increase in fatigue life.
Brown, Eric N., Sottos, Nancy R., White, Scott R.   +2 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Summary of the NECTOS study of specialist crack services [PDF]

, 2007
The Government acknowledges that crack and cocaine use is a significant public health issue. It has attached a high priority to getting more crack users into treatment and retaining them, and commissioning new research into the effectiveness of different
Chantler, Khatidja, Hart, Jozella, Metrebian, Nicky, Rutter, Deborah, Weaver, Tim   +4 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source