Results 101 to 110 of about 1,354,072 (296)

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

FEM Simulations of Fatigue Crack Initiation in the Oligocrystalline Microstructure of Stents. [PDF]

Materials (Basel), 2023
Lasko G, Schmauder S, Yang Y, Weiss S, Dogahe K.   +4 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Determining crack initiation fracture toughness and crack initiation length using DIC and AE approach for HDPE materials

Materials & Design
Fracture toughness JIC (the critical J-integral at crack initiation) is a crucial indicator for characterizing the crack resistance of materials. For high density polyethylene (HDPE), the multi-specimen method is generally adopted to construct crack ...
Yue Zhang, Sixiang Liang, Wenjie Feng, Jingbo Duan   +3 more
doaj   +1 more source

Crack initiation in elastic bodies

, 2005
In this paper we study the crack initiation in a hyper-elastic body governed by a Griffith's type energy. We prove that, during a load process through a time dependent boundary datum of the type $t \to t g(x)$ and in absence of strong singularities (this is the case of homogeneous isotropic materials) the crack initiation is brutal, i.e., a big crack ...
Chambolle, Antonin, Giacomini, Alessandro, Ponsiglione, Marcello   +2 more
openaire   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Experimental Research on the Propagation Mode of 3D Hollow Cracks and Material Strength Characteristics Under Hydro-Mechanical Coupling

Journal of Marine Science and Engineering
The fracture evolution and the strength characteristics of a jointed rock mass under hydro-mechanical coupling are key issues that affect the safety and stability of underground engineering.
Bangxiang Li, Guanhua Wang, Dongyang Xu, Hongbo Zhao   +3 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Experimental Studies on the Crack Initiation and Propagation of Hydraulic Fracturing with Different Coal Structure Combinations. [PDF]

ACS Omega, 2023
Liu D, Shu L, Wang Y, Ni X, Huo Z, Wang W.   +5 more
europepmc   +1 more source