Results 71 to 80 of about 1,354,072 (296)

Experimental and Theoretical Determination of the Frost-Heave Cracking Law and the Crack Propagation Criterion of Slab Track with Water in the Crack

Applied Sciences, 2019
Crack propagation produced by frost heave affects the durability of slab-track structures in high-humidity and cold regions in China. This work is intended to reveal the evolution laws of frost-heave crack propagation, establish evaluation criteria for ...
Fengzhuang Tong, Liang Gao, Xiaopei Cai, Yanglong Zhong, Wenqiang Zhao, Yichen Huang   +5 more
doaj   +1 more source

Fatigue crack initiation site and propagation paths in high-cycle fatigue of magnesium alloy AZ31

International Journal of Fatigue, 2019
Plane bending fatigue tests were conducted under stress ratios of −1, −0.1, 0.1, and 0.5 at room temperature in a laboratory atmosphere to elucidate the fatigue crack initiation mechanism of an extruded AZ31 magnesium alloy.
Y. Nakai, M. Saka, H. Yoshida, Kaito Asayama, S. Kikuchi   +4 more
semanticscholar   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The Initiation Characteristics of Corrosion Fatigue Crack in 18Ni (250) Steel

Journal of Marine Science and Engineering
Maraging steel is the material of deep sea pressure equipment. The characteristics of corrosion fatigue crack initiation in 18Ni (250) were investigated by performing a tensile fatigue test under different loading conditions.
Hongzhang Pan, Yongmei Zhu, Mingjiang Fang   +2 more
doaj   +1 more source

Experimental characterization and numerical modeling of crack initiation in rhombus hole PMMA specimens under compression

European Journal of Mechanics - A/Solids, 2019
Under compression, mode I cracking in the loading direction is observed in PMMA rhombus hole specimens. Except for specimens containing flaws, spontaneous initiation is observed experimentally with the abrupt nucleation of a crack at the rhombus V-notch ...
A. Doitrand, R. Estevez, D. Leguillon
semanticscholar   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Fatigue Crack Initiation and Small Crack Propagation Behaviors of Simulated Specimens in a Ni-Based Superalloy

Metals
The role of notch geometry and stress levels on fatigue crack initiation and small crack propagation behavior in the FGH96 superalloy was investigated using groove and bolt hole simulated specimens at 500 °C.
Zuopeng Zhao, Xuteng Hu, Zhiwei Guo
doaj   +1 more source