Results 91 to 100 of about 66,884 (287)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

SIMULATION STUDY ON OPENING MECHANISM OF THERMALMECHANICAL CRACK OF BRAKE DISC

Jixie qiangdu, 2017
Considering physical properties variation of gray cast iron with temperature,difference mechanical behavior of material between compression and tension,relationship of elastic and plastic stress-strain of material,synthetically studied the temperature ...
NI Jing, SHI LiFeng, ZHENG LingNan, YANG Xiao   +3 more
doaj  

The elasticity problem for a thick-walled cylinder containing a circumferential crack [PDF]

The elasticity problem for a long hollow circular cylinder containing an axisymmetric circumferential crack subjected to general nonaxisymmetric external loads is considered.
Erdogan, F., Nied, H. F.
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Numerical calibration of the stable poisson loaded specimen [PDF]

An analytical calibration of the Stable Poisson Loaded (SPL) specimen is presented. The specimen configuration is similar to the ASTM E-561 compact-tension specimen with displacement controlled wedge loading used for R-Curve determination.
Brewer, Dave N., Calomino, Anthony M., Ghosn, Louis J.   +2 more
core   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Simulation of fatigue crack opening in alloy D16T under constant amplitude loading using finite element method [PDF]

, 2013
Створено модель плоского зразка з центральною тріщиною в пружно-пластичній постановці за допомогою методу скінченних елементів. Обґрунтовано вибір розмірів скінченних елементів в околі вістря тріщини.
Fostyk, V., Galushchak, O., Pyndus, Y., Yasniy, P., Галущак, О., Пиндус, Юрій Іванович, Фостик, Василь Богданович, Ясній, Петро Володимирович   +7 more
core  

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Numerical Simulation Study on the Fracture Process of CFRP-Reinforced Concrete

Buildings
To investigate the crack extension mechanism in CFRP-reinforced concrete, this paper derives analytical expressions for the external load and crack opening displacement in the fracture process of CFRP concrete beams based on the crack emergence toughness
Xiangqian Fan, Jueding Liu, Li Zou, Juan Wang   +3 more
doaj   +1 more source

Mode I Critical Stress Intensity Factor of Medium - Density Fiberboard Obtained by Single-Edge - Notched Bending Test

Drvna Industrija, 2014
The Mode I critical stress intensity factor (KIc) obtained by single-edge-notched bending (SENB) tests of medium-density fiberboard (MDF) was experimentally analyzed.
Hiroshi Yoshihara, Hikaru Mizuno
doaj   +1 more source