Results 41 to 50 of about 66,884 (287)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
AlloysUsing the results from testing industrial batches of 23 mm steel heavy plates after thermomechanical rolling and subsequent post-weld heat treatment, the patterns of fatigue crack formation in the fracture specimens during CTOD (Crack Tip Opening ...
Eugene Goli-Oglu +2 more
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Jixie qiangdu, 2015 In this article,elastic-plastic curved crack tip opening displacement in hardened material under quasi-static loads has been mainly studied,and curved crack tip opening displacement has been calculated as a practical application of a second order ...
YANG DaPeng +4 more
doaj
Automatic and time-resolved determination of fracture characteristics from in situ experiments
Materials & DesignThe characterization of materials in ever smaller dimensions is crucial for the growing demand for miniaturized devices. Hence, in situ fracture experiments are frequently performed at the micron to sub-micron scale. To evaluate fracture process of these
K. Schmuck +3 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Results in Physics, 2016 FV520B steel is a kind of precipitation hardening Martensitic stainless steel, it has high-strength, good plasticity and good corrosion resistance.
Ming Qin +3 more
doaj +1 more source
Tensile Test Analysis of Tire Tread Rubber’s Tendency to Resist Cracks
Applied Sciences, 2022 Among the various components of a tire, this study explores the tread portion, which has the longest contact with the ground during the summer, all-weather, and in the winter.
Ingyu Noh, Sangyeop Hong, Jaehoon Kim
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source