Results 191 to 200 of about 26,802 (257)

Ganoderic Acid A Enhances Glycometabolism in Mouse Gastrocnemius Muscle During Exercise‐Induced Fatigue via AMPK/PGC‐1α Pathway Activation

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
This study investigated the effects of GAA, an active ingredient in Ganoderma lucidum, on exercise‐induced fatigue. GAA effectively enhances exercise performance by improving endurance duration while simultaneously reducing metabolic byproducts and muscle fiber damage.
Jialin Zhu, Fenglin Peng, Lin Zhang, Yanju Guo, Weiguo Liu, Jingrong Li, Shuju Shang, Bohan Zhang, Taotao Qiu   +8 more
wiley   +1 more source

Probing binding and occlusion of substrate in the human creatine transporter-1 by computation and mutagenesis. [PDF]

Protein Sci
Clarke A, Farr CV, El-Kasaby A, Szöllősi D, Freissmuth M, Sucic S, Stockner T.   +6 more
europepmc   +1 more source

Iron, arginine, and redox metabolism in peripheral blood mononuclear cells distinguishes sickle cell disease and pulmonary hypertension

HemaSphere, Volume 10, Issue 3, March 2026.
Abstract Pulmonary hypertension (PH) is a severe vascular complication of sickle cell disease (SCD); yet, not all patients with SCD develop PH, and PH also arises independently. This duality underscores the need to understand their intersecting biology.
Francesca I. Cendali, Christina Lisk, Amy Argabright, Monika Dzieciatkowska, Nishant K. Rana, Delaney Swindle, Daniel Stephenson, Julie McAfee, Natalie Westover, Melissa Lucero, Aneta Gandjeva, Kurt Stenmark, Rubin Tuder, Brian B. Graham, Tim Lahm, Vijaya Karoor, Gemlyn George, Kathryn Hassel, Rachelle Nuss, Pavel Davizon‐Castillio, Paul W. Buehler, Angelo D'Alessandro, David C. Irwin   +22 more
wiley   +1 more source

Mitochondrial Abnormalities of T Lymphocytes in Patients With Maintenance Hemodialysis

Immunity, Inflammation and Disease, Volume 14, Issue 3, March 2026.
ABSTRACT Objective To investigate the characteristics of T lymphocyte subsets and mitochondrial function in hemodialysis patients and to explore the effect of hemodialysis on these parameters. Methods Patients with end‐stage renal disease (ESRD) from July 2023 to June 2024, who underwent mitochondrial function detection of T lymphocyte subsets, were ...
Chunlei Luo, Sizeng Bao, Xueyan Bian, Lingling Bao, Chunyang Ji, Jianwei Ma, Jiancheng Huang   +6 more
wiley   +1 more source

Risk of recurrent diabetic ketoacidosis following initiation of sodium‐glucose co‐transporter 2 inhibitors in patients with an insulin‐deficient diabetes and prior diabetic ketoacidosis: An observational cohort study

Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 3408-3410, April 2026.
Anat Tsur, Omer Hamtzany, Rena Pollack, Avivit Cahn   +3 more
wiley   +1 more source

Intact pulse cotyledon cell diet improves systemic growth via the somatotropic axis in malnourished mice

iMetaOmics, Volume 3, Issue 1, March 2026.
The MAL‐IC diet promotes growth in malnourished mice by regulating the gut microbiota—increasing the abundance of carbohydrate‐utilizing bacteria and SCFAs production. SCFAs circulate to the liver via the gut–liver axis, where they bind FFAR2 and activate the somatotropic axis, thereby stimulating GHR‐mediated GH signaling and increasing IGF‐1 and ...
Yumeng Yan, Zhuqing Xie, Zhipeng Gu, Zhongxin Li, Qiang Huang, Bin Zhang   +5 more
wiley   +1 more source

From Pharmaceutical to Biophysical Therapies: New Horizons in Inflammatory Bowel Disease Management

JCC Plus, Volume 1, Issue 2, March 2026.
Important limitations exist in the current pharmacological landscape of Inflammatory Bowel Disease (IBD), such as variable response rates and treatment‐limiting adverse effects. In this review, we perform a critical assessment of the current literature on novel multimodal biophysical approaches showing alternative mechanisms of action to, and potential
Benedetta Ricchi, Alejandra A. Carriles, Samuel Elias Pineda Chavez, Stefanos Bonovas, Arianna Dal Buono, Cristina Bezzio, Alessandro Armuzzi, Stefania Vetrano   +7 more
wiley   +1 more source

Characterization of seizures and EEG findings in creatine transporter deficiency due to SLC6A8 mutation. [PDF]

Am J Med Genet A
Abdennadher M, Inati SK, Rahhal S, Khan O, Bartolini L, Thurm A, Theodore W, Miller JS, Porter FD, Bianconi S.   +9 more
europepmc   +1 more source

Population Pharmacokinetic Modeling Practice of Time‐Varying Clearance: Insights from a First‐in‐Human Study Case

The Journal of Clinical Pharmacology, Volume 66, Issue 3, March 2026.
Abstract Accurate characterization of time‐varying clearance (CL) is critical during early drug development, as it informs clinical study design and dosing strategies for future trials. However, detecting and modeling time‐varying clearance is challenging due to limited data availability in early clinical development.
Yongjun Hu, Lan Gao, Ronald Kong
wiley   +1 more source

Deletion of the Creatine Transporter (Slc6a8) in Dopaminergic Neurons Leads to Hyperactivity in Mice. [PDF]

J Mol Neurosci, 2020
Abdulla ZI, Pahlevani B, Lundgren KH, Pennington JL, Udobi KC, Seroogy KB, Skelton MR.   +6 more
europepmc   +1 more source