Results 201 to 210 of about 26,802 (257)
ABSTRACT Resistance exercise augments circulating extracellular vesicle (EV) and metabolite signalling in manners that assist musculoskeletal and systemic adaptations. Women are often underrepresented in exercise research and recent attention has focused on whether hormonal fluctuations during the menstrual cycle and use of hormonal contraception (HC ...
Christopher K. Kargl +13 more
wiley +1 more source
Rescue of myocytes and locomotion through AAV2/9-2YF intracisternal gene therapy in a rat model of creatine transporter deficiency. [PDF]
Fernandes-Pires G +8 more
europepmc +1 more source
Cyclocreatine treatment ameliorates the cognitive, autistic and epileptic phenotype in a mouse model of Creatine Transporter Deficiency. [PDF]
Cacciante F +14 more
europepmc +1 more source
ABSTRACT Extracellular vesicles (EVs) are nanoscale carriers of bioactive molecules that mediate intercellular communication. Small EVs (sEVs) have shown cardioprotective effects in models of myocardial infarction (MI), but their uptake and biodistribution remain incompletely understood.
Elias Sulaiman +2 more
wiley +1 more source
Reduced Dietary Protein Induces Changes in the Dental Proteome
Low dietary protein (10%) from normal (20%) does change protein expression in tooth proteome and alter developmental pathways. Among the significant protein expressions changes are actin‐based myosins, tooth, and bone development proteins. Perplexingly tooth size is not altered, suggesting more nuanced phenotypic response to low dietary protein in ...
Robert W. Burroughs +2 more
wiley +1 more source
Abstract The isoproterenol‐induced myocardial infarction model is a well‐established experimental approach for studying cardiac injury and testing potential protective treatments. By overstimulating beta‐adrenergic receptors, this model closely reproduces key features of human heart attacks, including oxidative damage, calcium imbalance, inflammatory ...
Bushra Imran +5 more
wiley +1 more source
Studies of structural determinants of substrate binding in the Creatine Transporter (CreaT, SLC6A8) using molecular models. [PDF]
Colas C, Banci G, Martini R, Ecker GF.
europepmc +1 more source
ABSTRACT Succinate dehydrogenase (SDH) serves a dual function as complex II of the electron transport chain and an enzyme of the tricarboxylic acid cycle. Pathogenic variants in subunits of SDH result in diverse clinical presentations, including typically autosomal recessive neurodegenerative disorders. Biallelic variants in the SDHA subunit most often
Aaron B. Bowen +7 more
wiley +1 more source
Slc7a11‐mediated cystine uptake and glutathione synthesis inhibits M1 macrophage polarization by reducing Stat1 phosphorylation and markers expressions and promotes M2 macrophage polarization by enhancing Stat6 phosphorylation and markers expressions.
Shuaishuai Zhou +12 more
wiley +1 more source
Creatine Transporter, Reduced in Colon Tissues From Patients With Inflammatory Bowel Diseases, Regulates Energy Balance in Intestinal Epithelial Cells, Epithelial Integrity, and Barrier Function. [PDF]
Hall CHT +8 more
europepmc +1 more source

