Results 211 to 220 of about 26,802 (257)
MedComm, Volume 7, Issue 3, March 2026.Female‐specific renal GluCer accumulation disrupts mitochondrial quality control via a conserved purine‐mTORC1 pathway, triggering a wave of uremic toxins into the systemic circulation that constitutes a female‐biased vulnerability toward renal‐driven multiorgan senescence.
Zhen Ni +18 more
wiley +1 more source
Urine Metabolism Biomarkers Predict Preterm Infant Adiposity at Hospital Discharge
Molecular Nutrition &Food Research, Volume 70, Issue 6, 29 March 2026.In this cohort of term and preterm infants, urinary amino acid and acylcarnitine concentrations varied by diabetes in pregnancy exposure and gestational age at birth, and certain patterns of urinary metabolites were differentially related to postnatal adiposity development in preterm infants of women with diabetes in pregnancy. ABSTRACT In infants born
Catherine O. Buck +5 more
wiley +1 more source
NMR in Biomedicine, Volume 39, Issue 3, March 2026.Retinal metabolic changes were analyzed using proton magnetic resonance spectroscopy (1H‐MRS), marking an initial application of this non‐invasive method on living eyes. Key metabolites were identified within the retinal region of adult rats. The observed changes following intense blue light exposure were predominantly attributable to the retina, as it
Lacramioara Samoila +10 more
wiley +1 more source
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 3, March 2026.ABSTRACT Background Tacrolimus is primarily metabolized by Cytochrome P450 (CYP)3A4/5. The Clinical Pharmacogenetics Implementation Consortium recommends increasing the initial dose 1.5‐ to 2‐fold in CYP3A5 expressers to enhance transplant outcomes. Our objective was to investigate the impact of CYP3A5 expresser status on tacrolimus dosing requirements
Yanting Wu +6 more
wiley +1 more source
Assessment of Blood Profiles and Pain in Sport Horses Undergoing Intrarectal Ozone Therapy
Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.Ozone therapy influenced haemoglobin, MCHC, and AST activity in horses, with transient red blood cell deformities and increased pain scores observed. No clinical symptoms or liver damage occurred. Findings suggest that lower ozone concentrations may reduce treatment‐related discomfort while maintaining therapeutic effects.
Thamirys Dias de Luna Paiva +5 more
wiley +1 more source
A Multi‐Organ Atlas Links Gut Microbial Metabolites to Systemic Redox Changes in Aging Mice
Aging Cell, Volume 25, Issue 3, March 2026.A gut‐derived metabolic signature drives systemic aging phenotypes. Integrated multi‐omics profiling of young versus aged mice identifies a conserved aging signature characterized by the depletion of protective lysophosphatidylcholines (LPC 22:0) and the concurrent accumulation of pro‐oxidative microbial catabolites (TMAO, IAA).
Sanaullah Sajid +6 more
wiley +1 more source
Microscopic and molecular aspects of skeletal muscle alterations in cerebral palsy
Developmental Medicine &Child Neurology, Volume 68, Issue 3, Page 343-357, March 2026.Cerebral palsy, caused by non‐progressive brain injury, is frequently accompanied by skeletal muscle alterations. This review synthesizes current evidence from muscle biopsy studies, revealing cellular and molecular adaptations in muscle tissue. Abstract Cerebral palsy (CP), the most prevalent childhood‐onset motor disability, frequently entails ...
Sebastian Edman +4 more
wiley +1 more source
Deletion of the creatine transporter gene in neonatal, but not adult, mice leads to cognitive deficits. [PDF]
J Inherit Metab Dis, 2019 Udobi KC +5 more
europepmc +1 more source
European Journal of Neurology, Volume 33, Issue 3, March 2026.Multiple acyl‐coenzyme A dehydrogenase deficiency‐like disease has recently been described as a rare adverse effect of sertraline. We performed a nationwide population‐based retrospective study in Sweden (2014–2024) including 40 patients, corresponding to an incidence of 1.24 per 100,000 treated individuals per year.
Sofie Sunebo +9 more
wiley +1 more source