Results 231 to 240 of about 26,802 (257)

Creatine transporters: A reappraisal

Molecular and Cellular Biochemistry, 2004
Creatine (Cr) plays a key role in cellular energy metabolism and is found at high concentrations in metabolically active cells such as skeletal muscle and neurons. These, and a variety of other cells, take up Cr from the extra cellular fluid by a high affinity Na(+)/Cl(-)-dependent creatine transporter (CrT). Mutations in the crt gene, found in several
Speer, Oliver, Neukomm, Lukas, Murphy, Robyn, Zanolla, Elsa, Schlattner, Uwe, Henry, Hugues, Snow, Rodney, Wallimann, Theo   +7 more
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SLC6A and SLC16A family of transporters: Contribution to transport of creatine and creatine precursors in creatine biosynthesis and distribution

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2022
Creatine (Cr) is needed to maintain high energy levels in cells. Since Cr plays reportedly a critical role in neurodevelopment and the immune system, Cr dynamics should be strictly regulated to control these physiological events. This review focuses on the role of transporters that recognize Cr and/or Cr precursors.
Ryuta, Jomura, Shin-Ichi, Akanuma, Masanori, Tachikawa, Ken-Ichi, Hosoya   +3 more
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Congenital Creatine Transporter Deficiency

Neuropediatrics, 2002
Two inborn errors of metabolism of creatine synthesis as well as the X-linked creatine transporter (SLC6A8) deficiency have been recognized. This report describes the features of five identified male patients and their female relatives who are carriers of the X-linked creatine transporter deficiency syndrome.Proton MR spectroscopy was used to recognize
T J, deGrauw, G S, Salomons, K M, Cecil, G, Chuck, A, Newmeyer, M B, Schapiro, C, Jakobs   +6 more
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Myocellular Creatine and Creatine Transporter Serine Phosphorylation after Starvation

Journal of Surgical Research, 2002
Myocellular creatine, which is critically important for normal energy metabolism, increases in rat gastrocnemius muscle after starvation via unknown mechanisms. Creatine (Cr) uptake across plasma membranes is governed by a single, specific transporter (CrTr) that shares 50% amino acid sequence identity with GABA/choline/betaine transporters whose ...
Chun-Rui, Zhao, Lihong, Shang, Weiyang, Wang, Danny O, Jacobs   +3 more
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Creatine transporter and mitochondrial creatine kinase protein content in myopathies

Muscle & Nerve, 2001
AbstractTotal creatine or phosphocreatine, or both, are reduced in the skeletal muscle of patients with inflammatory myopathy, mitochondrial myopathy, and muscular dystrophy/congenital myopathy. We used Western blotting techniques to measure skeletal muscle creatine transporter protein and sarcomeric mitochondrial creatine kinase (mtCK) protein content
Tarnopolsky, M. A., Parshad, A., Walzel, B., Schlattner, Uwe, Wallimann, Theo   +4 more
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Muscle creatine uptake and creatine transporter expression in response to creatine supplementation and depletion

Journal of Applied Physiology, 2003
The total creatine pool size [Crtotal; creatine (Cr) + phosphocreatine (PCr)] is crucial for optimal energy utilization in skeletal muscle, especially at the onset of exercise and during intense contractions. The Crtotallikely is controlled by long-term modulation of Cr uptake via the sodium-dependent Cr transporter (CrT).
Jeffrey J, Brault, Kirk A, Abraham, Ronald L, Terjung   +2 more
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Brain Creatine Kinase and Creatine Transporter Proteins in Normal and Creatine-Treated Rabbit Pups

Developmental Neuroscience, 2000
Systemic creatine (Cr) supplementation increases brain phosphocreatine (PCr) and prevents hypoxic seizures in 15-day-old rabbits . Between 5 and 30 days of age during normal development, rabbit gray matter mitochondrial creatine kinase (Mi-CK) increases 400% while cytosolic CK (BB-CK) increases 60%.
T, Kekelidze, I, Khait, A, Togliatti, D, Holtzman   +3 more
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Disorders of creatine transport and metabolism

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 2011
AbstractCreatine is a nitrogen containing compound that serves as an energy shuttle between the mitochondrial sites of ATP production and the cytosol where ATP is utilized. There are two known disorders of creatine synthesis (both transmitted as autosomal recessive traits: arginine: glycine amidinotransferase (AGAT) deficiency; OMIM 602360; and ...
Nicola, Longo, Orly, Ardon, Rena, Vanzo, Elizabeth, Schwartz, Marzia, Pasquali   +4 more
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Creatine Transporter Deficiency

2011
Abstract This chapter provides pictures and clinical details of CREATINE TRANSPORTER ...
Roger E. Stevenson, Charles E. Schwartz, R. Curtis Rogers   +2 more
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Irreversible brain creatine deficiency with elevated serum and urine creatine: A creatine transporter defect?

Annals of Neurology, 2001
AbstractRecent reports highlight the utility of in vivo magnetic resonance spectroscopy (MRS) techniques to recognize creatine deficiency syndromes affecting the central nervous system (CNS). Reported cases demonstrate partial reversibility of neurologic symptoms upon restoration of CNS creatine levels with the administration of oral creatine.
K M, Cecil, G S, Salomons, W S, Ball, B, Wong, G, Chuck, N M, Verhoeven, C, Jakobs, T J, DeGrauw   +7 more
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