Regulation of the Na+,Cl- Coupled Creatine Transporter CreaT (SLC6A8) by the Janus Kinase JAK3
Neurosignals, 2015 Background: The creatine transporter CreaT (SLC6A8), a Na+,Cl- coupled transporter is expressed in diverse tissues including the brain. Genetic defects of SLC6A8 result in mental retardation with seizures.
Myriam Fezai +2 more
doaj +1 more source
Muscle carnosine metabolism and β-alanine supplementation in relation to exercise and training [PDF]
, 2010 Carnosine is a dipeptide with a high concentration in mammalian skeletal muscle. It is synthesized by carnosine synthase from the amino acids L-histidine and beta-alanine, of which the latter is the rate-limiting precursor, and degraded by carnosinase ...
Baguet, Audrey +3 more
core +2 more sources
Creatine Kinase and Creatine Transporter in Normal, Wounded, and Diseased Skin [PDF]
Journal of Investigative Dermatology, 2002 Skin comprises many cell types that are characterized by high biosynthetic activity and increased energy turnover. The creatine kinase system, consisting of creatine kinase isoenzymes and creatine transporter, is known to be important to support the high energy demands in such cells.
Schlattner, Uwe +4 more
openaire +2 more sources
American Journal of Physiology-Endocrinology and Metabolism, 2002 Despite the pivotal role of creatine (Cr) and phosphocreatine (PCr) in muscle metabolism, relatively little is known about sarcolemmal creatine transport, creatine transporter (CRT) isoforms, and subcellular localization of the CRT proteins. To be able to quantify creatine transport across the sarcolemma, we have developed a new in vitro assay using ...
Walzel, Bernd +8 more
openaire +4 more sources
Creatine transporter deficiency: Novel mutations and functional studies
Molecular Genetics and Metabolism Reports, 2016 X-linked cerebral creatine deficiency (MIM 300036) is caused by deficiency of the creatine transporter encoded by the SLC6A8 gene. Here we report three patients with this condition from Israel.
O. Ardon +12 more
doaj +1 more source
Poultry Science, 2020 Supplementation of broiler breeder hens with beneficial additives bears great potential for affecting nutrient deposition into the fertile egg. Guanidinoacetate (GAA) is the endogenous precursor of creatine that is used as a feed additive for improving ...
Naama Reicher +6 more
doaj +1 more source
Potential therapeutic use of the ketogenic diet in autism spectrum disorders. [PDF]
, 2014 The ketogenic diet (KGD) has been recognized as an effective treatment for individuals with glucose transporter 1 (GLUT1) and pyruvate dehydrogenase (PDH) deficiencies as well as with epilepsy.
Dueñas, Nadia +2 more
core +1 more source
Negative Regulation of the Creatine Transporter SLC6A8 by SPAK and OSR1
Kidney & Blood Pressure Research, 2014 Background/Aims: Transport regulation involves several kinases including SPAK (SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase 1), which are under control of WNK (with-no-K[Lys]) kinases.
Myriam Fezai +5 more
doaj +1 more source
A metabolomic approach to animal vitreous humor topographical composition: A pilot study [PDF]
, 2014 The purpose of this study was to evaluate the feasibility of a 1H-NMR-based metabolomic approach to explore the metabolomic signature of different topographical areas of vitreous humor (VH) in an animal model.
ATZORI, LUIGI +8 more
core +1 more source
Programming Skeletal Muscle Metabolic Flexibility in Offspring of Male Rats in Response to Maternal Consumption of Slow Digesting Carbohydrates during Pregnancy [PDF]
, 2020 Skeletal muscle plays a relevant role in metabolic flexibility and fuel usage and the associated muscle metabolic inflexibility due to high-fat diets contributing to obesity and type 2 diabetes.
Andújar, Eloísa +7 more
core +1 more source