Results 91 to 100 of about 652,157 (334)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Do creative industries cluster? Mapping Creative Local Production Systems in Italy [PDF]

open access: yes
An important debate on the role of creativity and culture as factors of local economic development is distinctly emerging. Despite the emphasis put on the theoretical definition of these concepts, it is necessary to strengthen comparative research for ...
Francesco Capone   +2 more
core  

The Deadly Hopes in Trans Women’s Lives: Comparison of Indonesian Film “Lovely Man” and Japanese Film “Midnight Swan

open access: yesHumanities
This paper will discuss the depiction of trans women in the films Lovely Man and Midnight Swan, comparing the two main characters, Ipuy and Nagisa.
Marisa Rianti Sutanto   +2 more
doaj   +1 more source

Reading the Creative Industries With Deleuze: How Creative Are the Creative Industries?

open access: yesQualitative Inquiry
This article develops a definition of creativity that is informed by the work of Gilles Deleuze, Dan Harris, Susan Luckman, and others. We explore its application in the context of the creative industries in Australia. Through our empirical interviews conducted as part of an Australian Research Council–funded project called Vital Arts, we delve into ...
Alexia Cameron, Anna Hickey-Moody
openaire   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Critique of Creativity: Precarity, Subjectivity and Resistance in the ‘Creative Industries’ [PDF]

open access: yes, 2011
234 p. : il., Tablas.Libro ElectrónicoLa creatividad siempre está en movimiento: surge, se establece en el ente colectivo, palidece y desaparece a veces en el olvido; renace, vuelve con innovaciones, se reformula y resurge iniciando de nuevo el ciclo.
Raunig, Gerald (Ed.)   +2 more
core  

Diversifying the creative: Creative work, creative industries, creative identities [PDF]

open access: yesOrganization, 2017
Finkel, Rebecca   +3 more
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

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