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Targeting CREB signalling in neurogenesis
Expert Opinion on Therapeutic Targets, 2010Expansion and ultimately homeostasis of neural cell number is exquisitely regulated by molecular genetic networks operating in neural stem and progenitor cells (NSPCs) and in the neural stem cell niche during embryogenesis and in the adult brain. Transcription factors are crucial in orchestrating the correct cell-specific and temporal expression of all
Mantamadiotis, T
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Science's STKE, 2007
Although growth factors and stress stimulate the phosphorylation of cAMP response element-binding protein (CREB), these signals do not trigger the expression of the same genes as those activated by stimuli that activate cAMP signaling. Two groups (Ravnskjaer et al .
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Although growth factors and stress stimulate the phosphorylation of cAMP response element-binding protein (CREB), these signals do not trigger the expression of the same genes as those activated by stimuli that activate cAMP signaling. Two groups (Ravnskjaer et al .
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[Transcriptional regulation by CREB and proteins of CREB family].
Sheng li ke xue jin zhan [Progress in physiology], 1998CREB (cAMP-responsive element binding protein), which can be activated after phosphorylation by protein kinase A, plays an important role in cAMP-induced gene expression. Several recent studies have suggested that a co-activator designated as CREB binding protein (CBP) is crucial in mediating the transcriptional activity of CREB.
J H, Tian, X M, Wang, J S, Han
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Cellular and Molecular Life Sciences (CMLS), 1999
The prevailing hypothesis for the formation of long-term memory (LTM) is that introduction of a memory item alters the pattern of existing neuronal connectivity to form a neuronal network that will subserve the information for long-term storage. Modulation of synaptic efficacy is induced by changes in synaptic transmission within selected synapses or ...
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The prevailing hypothesis for the formation of long-term memory (LTM) is that introduction of a memory item alters the pattern of existing neuronal connectivity to form a neuronal network that will subserve the information for long-term storage. Modulation of synaptic efficacy is induced by changes in synaptic transmission within selected synapses or ...
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CREB Binding Protein—Coactivator Complexes
2000CREB binding protein (CBP) and p300 are structurally related coactivator proteins that are required for the function of several classes of regulated transcription factors (Fig. 1). CBP and p300 function in part by serving as molecular scaffolds that direct the assembly of multiprotein coactivator complexes (Fig. 2).
Riki Kurokawa, Christopher K. Glass
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