Results 221 to 230 of about 146,934 (341)

AARS1‐mediated AKR1B10 lactylation stabilizes an aerobic glycolysis‐positive feedback loop to drive lenvatinib resistance in hepatocellular carcinoma

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
AKR1B10 confers lenvatinib resistance by enhancing aerobic glycolysis in HCC cells. AKR1B10 undergoes AARS1‐mediated lactylation at K173, stabilizing it by antagonizing ubiquitin‐proteasomal degradation. AKR1B10 promotes LDHA Y10 phosphorylation, boosting lactate production, which drives H3K18la‐mediated transcriptional upregulation of LDHA, creating a
Zijian Liu, Jingsheng Yuan, Shitong Su, Jiaqi Han, Ni Zeng, Yuhan Ma, Nianyong Chen, Tao Lv   +7 more
wiley   +1 more source

Cerebrolysin ameliorates ketamine-mediated anxiety and cognitive impairments via modulation of mitochondrial function and CREB/PGC-1α pathway. [PDF]

Mol Brain
Hosseini L, Abolhasanpour N, Seyedaghamiri F, Hassanzadeh P, Shahabi P, Mafikandi V, Kalejahi P, Rajabi M, Shokri Z, Fakhari A.   +9 more
europepmc   +1 more source

Caveolin-1 regulates lipid droplet metabolism in endothelial cells via autocrine prostacyclin–stimulated, cAMP-mediated lipolysis [PDF]

, 2018
Gross, Richard W., Kuo, Andrew, Lee, Monica Y., Sessa, William C., Yang, Kui   +4 more
core   +2 more sources

Supplementary Table S2 from Targeting CREB Pathway Suppresses Small Cell Lung Cancer

, 2023
Yifeng Xia, Cheng Zhan, Mingxiang Feng, Mathias Leblanc, Eugene Ke, Narayana Yeddula, Inder M. Verma   +6 more
openalex   +1 more source

Targeting the lactylation of ENO1 alleviates endothelial dysfunction in sepsis

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Lactylation of ENO1 reduced the binding of TRIM21 mRNA to ENO1, thereby preventing mRNA degradation. Elevated TRIM21 subsequently binds to VE‐Cadherin, promoting its ubiquitination. Targeting the lactylation of ENO1 with a specific inhibitory peptide alleviated endothelial dysfunction.
Xueru Xie, Tingyan Liu, Caiyan Zhang, Ye Cheng, Yajing Gao, Wenfeng Xiao, Haiyan Guo, Yutong Zhou, Yawei Yu, Kexin Wang, Yinghong Lin, Lisheng Xiao, Yingying Zhang, Weiguo Yang, Gangfeng Yan, Guoping Lu, Yufeng Zhou   +16 more
wiley   +1 more source

Qianzheng powder promotes facial nerve regeneration via BDNF/TrkB/CREB pathway activation. [PDF]

Regen Ther
Chen L, Wang C, Jiang L, Xie Q, Qin H, Zhang Z.   +5 more
europepmc   +1 more source

Calcineurin controls the expression of numerous genes in cerebellar granule cells [PDF]

, 2003
Ashby, Dominique S, Freeman, Tom C, Fresu, Luigia, Genazzani, Armando A, Kramer, Dana   +4 more
core   +1 more source

Natural Dietary Compounds Targeting NF‐κB Signaling in Cancer: Implications for Nutrition‐Based Prevention and Therapy

Food Frontiers, Volume 7, Issue 1, January 2026.
ABSTRACT Dysregulation of the nuclear factor kappa B (NF‐κB) signaling pathway is closely associated with inflammation‐driven carcinogenesis, tumor progression and resistance to conventional therapies. Sustained NF‐κB activation enhances malignant cell survival, proliferation and immune evasion by promoting proinflammatory and antiapoptotic gene ...
Maria Sharif, Iqra Mutiullah, Kafila Kausar, Rashid Khan, Muhammad Irfan, Solomon Habtemariam, Khushbukhat Khan, Cristina Quispe, William C. Cho, Javad Sharifi‐Rad, Daniela Calina   +10 more
wiley   +1 more source

Comparative analysis of ERK and CREB activity in normal and cryptorchid testes of bulls. [PDF]

J Vet Sci
Yun C, Jeong S, Cho Y, Park SI, Shin IS, Park JG, Moon C, Kang S, Kim JS.   +8 more
europepmc   +1 more source

Effects of lentivirus‐mediated CREB expression in the dorsolateral striatum: Memory enhancement and evidence for competitive and cooperative interactions with the hippocampus [PDF]

, 2013
Balachandar Kathirvelu, Paul J. Colombo
openalex   +1 more source