Results 251 to 260 of about 146,934 (341)

Caffeine improves diethylnitrosamine-induced hepatocellular carcinoma by inhibiting cAMP/PKA/CREB signaling in rats. [PDF]

Biochem Biophys Rep
Shan L, Wang C, Fang X, Zhang Z, Dai S, Liu J.   +5 more
europepmc   +1 more source

Histamine H3 Receptor Promotes Cell Survival via Regulating PKA/CREB/CDKN1A Signal Pathway in Hepatocellular Carcinoma

, 2020
Chang Zhang, Yang Yu, Li Ma, Fu Ping
openalex   +1 more source

Uncoupling Insulin Sensitivity From Longevity: A Sex‐Dependent Effect of Hepatic Glucagon Signaling

Aging Cell, Volume 25, Issue 1, January 2026.
Hepatic glucagon receptor knockout enhances metabolic health but shortens lifespan in female mice due to late‐life inflammation via NF‐κB and cGAS‐STING pathways, revealing a sexually dimorphic role in longevity despite metabolic benefits. ABSTRACT Glucagon, a key hormone in maintaining euglycemia during fasting, also exerts broad metabolic effects ...
Alexander Tate Lasher, Ben Heckman, Parth Sarker, Kaimao Liu, Liou Y. Sun   +4 more
wiley   +1 more source

Adenosine/A_2AR/PKA signaling regulates HO-1-mediated anti-inflammatory responses during <i>Leishmania donovani</i> infection. [PDF]

mBio
Das T, Brahmachari P, Ukil A.
europepmc   +1 more source

Guanylyl cyclase/natriuretic peptide receptor-A signaling antagonizes the vascular endothelial growth factor-stimulated MAPKs and downstream effectors AP-1 and CREB in mouse mesangial cells

, 2012
Satyabha Tripathi, Kailash N. Pandey
openalex   +2 more sources

NRF2 signalling in cytoprotection and metabolism

British Journal of Pharmacology, Volume 183, Issue 1, Page 101-114, January 2026.
The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur ...
Shohei Murakami, Yusuke Kusano, Keito Okazaki, Takaaki Akaike, Hozumi Motohashi   +4 more
wiley   +1 more source

A Dual-compartment Scaffolding Role for Receptor for Activate C Kinase 1 in Hepatic Glucagon Signaling and Gluconeogenesis. [PDF]

Cell Mol Gastroenterol Hepatol
Lyu C, Yang L, Chen S.
europepmc   +1 more source

VRK1 Is a Novel Therapeutic Target for Small Cell Neuroendocrine Carcinoma of the Cervix

Cancer Science, Volume 117, Issue 1, Page 78-89, January 2026.
Small cell neuroendocrine carcinoma of the cervix (SCNEC), a rare but aggressive cancer, consistently exhibited high VRK1 expression. VRK1 knockdown significantly suppressed xenograft tumor growth by inducing mitochondrial dysfunction. These findings highlighted VRK1 as a potential therapeutic target for SCNEC.
Mariya Kobayashi, Satoshi Nakagawa, Yusuke Ishii, Yuji Kamei, Mizuki Kanda, Tatsuo Masuda, Mamoru Kakuda, Kosuke Hiramatsu, Tadashi Iwamiya, Tomomi Egawa‐Takata, Shinya Matsuzaki, Hiroyuki Uematsu, Kunishige Onuma, Masahiro Inoue, Yutaka Ueda, Tadashi Kimura, Michiko Kodama   +16 more
wiley   +1 more source

A distal enhancer of Pparα regulates thermogenesis and mitochondrial function in brown fat. [PDF]

PLoS Genet
Jiang T, Su D, Ke J, Dai X, Wang M, Wang Y, Zhan S, Zhong T, Guo J, Li L, Zhang H, Wang L.   +11 more
europepmc   +1 more source

Convergent Metabolic Pathways in MASH Therapeutics: An AMPK‐Centric Analysis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 2, January 2026.
ABSTRACT Metabolic dysfunction‐associated steatohepatitis (MASH) is a leading cause of liver‐related morbidity driven by systemic metabolic dysregulation. The recent approval of resmetirom and the clinical success of GLP‐1 receptor agonists have heralded a new era in MASH therapy, yet a convergent understanding of the complex mechanisms of these ...
Seungchan Choi, Jin‐Seok Jung, Yie‐sung Seo, Sungmin Song, Jeehye Ham, Hannah Chung, Yousef Ramadan, Kangchan Choi   +7 more
wiley   +1 more source