Results 71 to 80 of about 5,398,452 (282)
Scientific Reports, 2022 Mud shale, used in drilling engineering, is prone to hydration and expansion, resulting in creep deformation that leads to wellbore shrinkage and pipe sticking incidents.
Xinxin Fang +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
工程科学与技术, 2021 In the construction of water conservancy, hydropower, underwater tunnels and other geotechnical engineering, rock materials with initial damage are under the coupling action of axial compression and hydraulic pressure for a long time, which seriously ...
Defeng LIU +4 more
doaj
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The development of finite element software for creep damage analysis [PDF]
Creep deformation and failure in high temperature structures is a serious problem for industry and is becoming even more so under the current increasing pressures of power, economics and sustainability.
Liu, Dezheng
core +3 more sources
Creep Characteristics of Engineering Materials [PDF]
, 2020 Janusz Dobrzański, Adam Zieliński
openaire +3 more sources
Insights of the asynchronous strain evolution of lean coal in uniaxial compression creep
Scientific ReportsOwing to the heterogeneity, discontinuity and complex material structure, typical coal exhibits intricate deformation characteristics during long-term creep processes.
Tingting Cai +6 more
doaj +1 more source
Study on symmetric creep model based on creep curves and parametric sensitivity analysis
Meitan kexue jishuIn order to obtain the creep characteristics of the surrounding rock of the Dianzhong water diversion tunnel and to study the long-term stability of the surrounding rock of the tunnel, a fully automated triaxial developed by Wuhan Institute of ...
Wenbo LIU +3 more
doaj +1 more source