Results 41 to 50 of about 4,478 (256)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Parameter prediction of rheological models for hydraulic asphalt concrete using time-temperature superposition principle

Case Studies in Construction Materials
To further investigate the creep performance of hydraulic asphalt concrete, this study conducted flexural creep tests across varied temperatures and load levels (relative to flexural strength), obtaining creep strain curves, creep compliance profiles ...
Jing Dong, Mingwei Ren, Yunhe Liu, Benchi Zhang, Zhiyuan Ning, Yanlong Li, Liangliang Chen   +6 more
doaj   +1 more source

Multiscale Creep Compliance of Epoxy Networks at Elevated Temperatures [PDF]

Experimental Mechanics, 2006
Epoxy networks are thermoset polymers for which an important structural length scale, molecular weight between crosslinks (M c), influences physical and mechanical properties. In the present work, creep compliance was measured for three aliphatic epoxy networks of differing M c using both macroscale torsion and ...
T. F. Juliano, M. R. VanLandingham, C. A. Tweedie, K. J. Van Vliet   +3 more
openaire   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Experimental and numerical analyses of creep behaviour of composite bonded joints under mode I and mode II loading

Materials & Design
The creep behaviour of composite bonded joints under pure mode I and pure mode II loading was analysed in this work. Experimental tests were carried out on the Double Cantilever Beam and the End Notched Flexure under different load levels and the ...
R.F.M. Couto, M.F.S.F. de Moura, A.G. Magalhães, R.D.F. Moreira   +3 more
doaj   +1 more source

CURE DEPENDENT CREEP COMPLIANCE OF AN EPOXY RESIN

, 1999
The cure dependent creep compliance of a difunctional epoxide/tetrafunctional amine epoxy is investigated. Creep data at several cure states is taken over a range of temperatures and shifted according to time-temperature superposition to obtain master curves. The dependence of creep behavior on cure state is shown to be quite dramatic.
Daniel J. O'Brien, Scott R. White
openaire   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Effect of consolidation on the flexural creep behaviour of all-polypropylene composite

eXPRESS Polymer Letters, 2010
The long-term viscoelastic behaviour of self-reinforced polypropylene composites (SRPPC) was studied by short-term flexural creep tests at different temperatures.
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Non-aging basic creep of alkali-activated slag concrete: Multiscale characterization and modeling

Cement
This study focuses on a multiscale characterization of basic creep behavior of two AAS creep mixes with high (hS) and low (lS) slag content, loaded at 28 days.
Richard Caron, Ravi A. Patel, Andreas Bogner, Frank Dehn   +3 more
doaj   +1 more source