Results 51 to 60 of about 50,073 (302)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Non-aging basic creep of alkali-activated slag concrete: Multiscale characterization and modeling

Cement
This study focuses on a multiscale characterization of basic creep behavior of two AAS creep mixes with high (hS) and low (lS) slag content, loaded at 28 days.
Richard Caron, Ravi A. Patel, Andreas Bogner, Frank Dehn   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Anisotropic time-dependent behaviors of shale under direct shearing and associated empirical creep models

Journal of Rock Mechanics and Geotechnical Engineering
Understanding the anisotropic creep behaviors of shale under direct shearing is a challenging issue. In this context, we conducted shear-creep and steady-creep tests on shale with five bedding orientations (i.e.
Yachen Xie, Michael Z. Hou, Hejuan Liu, Cunbao Li   +3 more
doaj   +1 more source

Time dependent properties of thermoplastic protein produced from bloodmeal with sodium sulphite as an anti-crosslinking agent [PDF]

, 2012
The aim of this research was to investigate how the time dependent mechanical behaviour of bloodmeal-based thermoplastic was affected by varying sodium sulphite content at two injection moulding temperatures (120°C at exit or 140°C at exit ...
Bier, James Michael, Lay, Mark C., van der Merwe, De Wet, Verbeek, Casparus Johan R.   +3 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Boundary Effect Modeling In the Problem of Stochastic Heterogeneous Stripe Tension Under Creep

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2009
The boundary effect in stochastic creep boundary problem of endless heterogeneous stripe tension was modeled. Determining creep factors which were applied in compliance with a nonlinear theory of viscid flow are formulated in a stochastic form.
L. V. Kovalenko, N. N. Popov
doaj   +1 more source

Performance of TenCate Paving Interlayers in Asphalt Concrete Pavements [PDF]

, 2017
As a continued effort of a previously completed project entitled “Performance of TenCate Mirafi PGM-G4 Interlayer-Reinforced Asphalt Pavements in Alaska,” this project evaluated two newly modified paving interlayers (TruPave and Mirapave) through overlay,
Li, Lin, Liu, Jenny, Zhao, Sheng
core  

Maximum Likelihood Estimation for Single Particle, Passive Microrheology Data with Drift [PDF]

, 2016
Volume limitations and low yield thresholds of biological fluids have led to widespread use of passive microparticle rheology. The mean-squared-displacement (MSD) statistics of bead position time series (bead paths) are either applied directly to ...
Crib, Jeremy, Forest, M. Gregory, Hill, David B., Lysy, Martin, McKinley, Scott A., Mellnik, John W. R., Pillai, Natesh S., Vasquez, Paula A.   +7 more
core   +3 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source