Proteomic analysis of the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease [PDF]
, 2007 So far, only the detection of 14-3-3 proteins in cerebrospinal fluid (CSF) has been accepted as diagnostic criterion for Creutzfeldt-Jakob disease (CJD). However, this assay cannot be used for screening because of the high rate of false-positive results,
Brit Mollenhauer +19 more
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Cerebrospinal fluid biomarker supported diagnosis of Creutzfeldt-Jakob disease and rapid dementias:a longitudinal multicentre study over 10 years [PDF]
, 2012 To date, cerebrospinal fluid analysis, particularly protein 14-3-3 testing, presents an important approach in the identification of Creutzfeldt–Jakob disease cases.
Aguzzi, Adriano +20 more
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Iatrogenic CJD due to pituitary-derived growth hormone with genetically determined incubation times of up to 40 years [PDF]
, 2015 Patients with iatrogenic Creutzfeldt-Jakob disease due to administration of cadaver-sourced growth hormone during childhood are still being seen in the UK 30 years after cessation of this treatment.
Adlard, P +13 more
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Creutzfeldt-Jakob Disease Presenting as Nonconvulsive Status Epilepticus
Case Reports in Neurological Medicine, 2018 Creutzfeldt-Jakob disease is a rare, rapidly progressive spongiform encephalopathy in humans. EEG plays an important role in diagnosing this disease. In some patients, epileptic activity and encephalopathy from various aetiologies may share morphological
Aleksei Rakitin +5 more
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Detection of Infectivity in Blood of Persons with Variant and Sporadic Creutzfeldt-Jakob Disease
Emerging Infectious Diseases, 2014 We report the presence of infectivity in erythrocytes, leukocytes, and plasma of 1 person with variant Creutzfeldt-Jakob disease and in the plasma of 2 in 4 persons whose tests were positive for sporadic Creutzfeldt-Jakob disease.
Jean Yves Douet +11 more
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Frontiers in Neurology, 2023 The most frequently utilized biomarkers to support a pre-mortem clinical diagnosis of sporadic Creutzfeldt–Jakob disease (sCJD) include concentrations of the 14-3-3 and total tau (T-tau) proteins, as well as the application of protein amplification ...
Matteo Senesi +18 more
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Computational Studies of the Structural Stability of Rabbit Prion Protein Compared to Human and Mouse Prion Proteins [PDF]
, 2011 Prion diseases are invariably fatal and highly infectious neurodegenerative diseases affecting humans and animals. The neurodegenerative diseases such as Creutzfeldt-Jakob disease, variant Creutzfeldt-Jakob diseases, Gerstmann-Str$\ddot{a}$ussler ...
Zhang, Jiapu
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Creutzfeldt-Jakob disease and homocysteine levels in plasma and cerebrospinal fluid [PDF]
, 2005 Background: There is evidence that homocysteine contributes to various neurodegenerative disorders. Objective: To assess the values of homocysteine in patients with Creutzfeldt-Jakob disease (CJD) in both cerebrospinal fluid (CSF) and plasma.
Bottiglieri T +11 more
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Shortest known prion protein allele in highly BSE-susceptible lemurs [PDF]
, 2000 We describe the shortest prion protein allele known to date. Surprisingly, it is found as a polymorphism exactly in a species (prosimian lemurs) which seems highly susceptible to oral infection with BSE-derived prions. The truncation of the prion protein
Gilch, S. +2 more
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A Case of Sporadic Creutzfeldt-Jakob Disease Presenting as Conversion Disorder
Case Reports in Psychiatry, 2017 Background. Creutzfeldt-Jakob disease is a rare disorder of the central nervous system. Its initial diagnosis may be obscured by its variable presentation.
Nikhil Yegya-Raman +5 more
doaj +1 more source