Results 101 to 110 of about 216,867 (346)

Advances in application of CRISPR-Cas13a system

Frontiers in Cellular and Infection Microbiology
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPRs) and CRISPR-associated (Cas) proteins serve as an adaptive immune system that safeguards prokaryotes and some of the viruses that infect prokaryotes from foreign nucleic acids (such as ...
Yue Zhang, Shengjun Li, Rongrong Li, Xu Qiu, Tianyu Fan, Bin Wang, Bei Zhang, Li Zhang   +7 more
doaj   +1 more source

The Clustered Regularly Interspaced Short Palindromic Repeats-Associated System and Its Relationship With Mobile Genetic Elements in Klebsiella

Frontiers in Microbiology, 2022
Microorganisms have developed many strategies in the process of long-term defense against external attacks, one of which is the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated proteins (Cas) bacterial immunological ...
Yuqiao Zhou, Wei Zhou, Jinzhi Zhou, Jinchang Yan, Dingting Xu, Xiner Zheng, Shuaizhou Zong, Ping Jiang, Shiyi Tian, Jianzhong Han, Daofeng Qu   +10 more
doaj   +1 more source

Characterization and repurposing of the endogenous Type I-F CRISPR–Cas system of Zymomonas mobilis for genome engineering

bioRxiv, 2019
Establishment of production platform organisms through prokaryotic engineering represents an efficient means to generate alternatives for yielding renewable biochemicals and biofuels from sustainable resources.
Yanli Zheng, Jiamei Han, Wenyao Liang, Runxia Li, Xiaoyun Hu, Baiyang Wang, W. Shen, Xiangdong Ma, Lixin Ma, Li Yi, Shihui Yang, Wenfang Peng   +11 more
semanticscholar   +1 more source

Small and mighty: adaptation of superphylum Patescibacteria to groundwater environment drives their genome simplicity. [PDF]

, 2020
BackgroundThe newly defined superphylum Patescibacteria such as Parcubacteria (OD1) and Microgenomates (OP11) has been found to be prevalent in groundwater, sediment, lake, and other aquifer environments.
Adams, Benjamin G, Alm, Eric J, Arkin, Adam P, Detienne, Brittny L, Fields, Matthew W, Gao, Shuhong, Hazen, Terry C, He, Zhili, Joyner, Dominique C, Klingeman, Dawn M, Lowe, Kenneth A, Ning, Daliang, Rocha, Andrea M, Shi, Weiling, Spencer, Sarah J, Stahl, David A, Tian, Renmao, Wu, Linwei, Yang, Yunfeng, Zhang, Ping, Zhang, Ya, Zhou, Jizhong   +21 more
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

From Origin to the Present: Establishment, Mechanism, Evolutions and Biomedical Applications of the CRISPR/Cas-Based Macromolecular System in Brief

Molecules
Advancements in biological and medical science are intricately linked to the biological central dogma. In recent years, gene editing techniques, especially CRISPR/Cas systems, have emerged as powerful tools for modifying genetic information ...
Zheng Yuan
doaj   +1 more source

The Involvement of the csy1 Gene in the Antimicrobial Resistance of Acinetobacter baumannii

Frontiers in Medicine, 2022
Acinetobacter baumannii is an important, opportunistic nosocomial pathogen that causes a variety of nosocomial infections, and whose drug resistance rate has increased in recent years.
Tingting Guo, Tingting Guo, Tingting Guo, Xiaoli Sun, Mengying Li, Mengying Li, Yuhang Wang, Hongmei Jiao, Guocai Li, Guocai Li, Guocai Li   +10 more
doaj   +1 more source

CRISPR-Cas System: The Powerful Modulator of Accessory Genomes in Prokaryotes

Microbial Physiology, 2021
Being frequently exposed to foreign nucleic acids, bacteria and archaea have developed an ingenious adaptive defense system, called CRISPR-Cas. The system is composed of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) array ...
A. Butiuc-Keul, A. Farkas, R. Carpa, Dumitrana Iordache   +3 more
semanticscholar   +1 more source

Use of CRISPR/Cas system in genome-editing [PDF]

, 2013
CRISPR/Cas sustav u prokariota i arheja igra važnu ulogu u obrani od infektivnih čestica. Izučavanjem principa rada CRISPR/Cas sustava ustanovljeno je da se može iskoristiti u uređivanju kako prokariotskog tako i eukariotskog genoma.
Stojanović, Mario
core   +2 more sources

The size of the immune repertoire of bacteria

, 2019
Some bacteria and archaea possess an immune system, based on the CRISPR-Cas mechanism, that confers adaptive immunity against phage. In such species, individual bacteria maintain a "cassette" of viral DNA elements called spacers as a memory of past ...
Balasubramanian, Vijay, Bradde, Serena, Goyal, Sidhartha, Nourmohammad, Armita   +3 more
core   +1 more source