Results 101 to 110 of about 207,049 (372)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Regulation of CRISPR-Associated Genes by Rv1776c (CasR) in Mycobacterium tuberculosis

Biomolecules, 2023
The CRISPR-Cas system is an adaptive immune system for many bacteria and archaea to defend against foreign nucleic acid invasion, and this system is conserved in the genome of M. tuberculosis (Mtb).
Wenping Wei, Xiaofang Jiang, Li Zhang, Yunjun Yan, Jinyong Yan, Li Xu, Chun-Hui Gao, Min Yang   +7 more
doaj   +1 more source

CRISPR Content Correlates with the Pathogenic Potential of Escherichia coli [PDF]

, 2015
Guide RNA molecules (crRNA) produced from clustered regularly interspaced short palindromic repeat (CRISPR) arrays, altogether with effector proteins (Cas) encoded by cognate cas (CRISPR associated) genes, mount an interference mechanism (CRISPR-Cas ...
Almendros, Cristóbal, García-Gutiérrez, Enriqueta, García-Martínez, Jesús, Guzmán, Noemí M., Mojica, Francisco J.M.   +4 more
core   +4 more sources

CRISPR/Cas9 editing of endogenous banana streak virus in the B genome of Musa spp. overcomes a major challenge in banana breeding [PDF]

, 2020
Open Access Journal; Published online: 31 Jan 2019Presence of the integrated endogenous banana streak virus (eBSV) in the B genome of plantain (AAB) is a major challenge for breeding and dissemination of hybrids.
Britt, A., Muiruri, S.K., Ntui, V.O., Ron, M., Tripathi, J.N., Tripathi, L.   +5 more
core   +1 more source

Efficient genome editing in plants using a CRISPR/Cas system

Cell Research, 2013
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Zhengyan Feng, Botao Zhang, W. Ding, Xiaodong Liu, Dong-Lei Yang, Peng-lian Wei, Fengqiu Cao, Shihua Zhu, Feng Zhang, Yanfei Mao, Jian‐Kang Zhu   +10 more
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Advances in application of CRISPR-Cas13a system

Frontiers in Cellular and Infection Microbiology
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPRs) and CRISPR-associated (Cas) proteins serve as an adaptive immune system that safeguards prokaryotes and some of the viruses that infect prokaryotes from foreign nucleic acids (such as ...
Yue Zhang, Shengjun Li, Rongrong Li, Xu Qiu, Tianyu Fan, Bin Wang, Bei Zhang, Li Zhang   +7 more
doaj   +1 more source

The Clustered Regularly Interspaced Short Palindromic Repeats-Associated System and Its Relationship With Mobile Genetic Elements in Klebsiella

Frontiers in Microbiology, 2022
Microorganisms have developed many strategies in the process of long-term defense against external attacks, one of which is the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated proteins (Cas) bacterial immunological ...
Yuqiao Zhou, Wei Zhou, Jinzhi Zhou, Jinchang Yan, Dingting Xu, Xiner Zheng, Shuaizhou Zong, Ping Jiang, Shiyi Tian, Jianzhong Han, Daofeng Qu   +10 more
doaj   +1 more source

Small and mighty: adaptation of superphylum Patescibacteria to groundwater environment drives their genome simplicity. [PDF]

, 2020
BackgroundThe newly defined superphylum Patescibacteria such as Parcubacteria (OD1) and Microgenomates (OP11) has been found to be prevalent in groundwater, sediment, lake, and other aquifer environments.
Adams, Benjamin G, Alm, Eric J, Arkin, Adam P, Detienne, Brittny L, Fields, Matthew W, Gao, Shuhong, Hazen, Terry C, He, Zhili, Joyner, Dominique C, Klingeman, Dawn M, Lowe, Kenneth A, Ning, Daliang, Rocha, Andrea M, Shi, Weiling, Spencer, Sarah J, Stahl, David A, Tian, Renmao, Wu, Linwei, Yang, Yunfeng, Zhang, Ping, Zhang, Ya, Zhou, Jizhong   +21 more
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source