Results 81 to 90 of about 18,275,652 (330)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The Clustered Regularly Interspaced Short Palindromic Repeats-Associated System and Its Relationship With Mobile Genetic Elements in Klebsiella

Frontiers in Microbiology, 2022
Microorganisms have developed many strategies in the process of long-term defense against external attacks, one of which is the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated proteins (Cas) bacterial immunological ...
Yuqiao Zhou, Wei Zhou, Jinzhi Zhou, Jinchang Yan, Dingting Xu, Xiner Zheng, Shuaizhou Zong, Ping Jiang, Shiyi Tian, Jianzhong Han, Daofeng Qu   +10 more
doaj   +1 more source

Unraveling the application of CRISPR/Cas system in natural product research

, 2023
Throughout human history, fruits have been consumed as a staple food that provides many nutrients, including vitamins, carbohydrates, minerals, and dietary fiber.
Ghosh, A., Biswas, P., Nandy, S., Ghorai, M., Pandey, D.K., Nongdam, P., Shekhawat, M.S.   +6 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Advances in application of CRISPR-Cas13a system

Frontiers in Cellular and Infection Microbiology
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPRs) and CRISPR-associated (Cas) proteins serve as an adaptive immune system that safeguards prokaryotes and some of the viruses that infect prokaryotes from foreign nucleic acids (such as ...
Yue Zhang, Shengjun Li, Rongrong Li, Xu Qiu, Tianyu Fan, Bin Wang, Bei Zhang, Li Zhang   +7 more
doaj   +1 more source

Functional Study of the Type II-A CRISPR-Cas System of Streptococcus agalactiae Hypervirulent Strains

, 2021
International audienceNearly all strains of Streptococcus agalactiae, the leading cause of invasive infections in neonates, encode a type II-A clustered regularly interspaced short palindromic repeats (CRISPR)-Cas system. Interestingly, S.
Horvath, Philippe, Pastuszka, Adeline, Mereghetti, Laurent, Beauruelle, Clémence, Rousseau, Geneviève, Moineau, Sylvain, Lanotte, Philippe, Camiade, Emilie   +7 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

From Origin to the Present: Establishment, Mechanism, Evolutions and Biomedical Applications of the CRISPR/Cas-Based Macromolecular System in Brief

Molecules
Advancements in biological and medical science are intricately linked to the biological central dogma. In recent years, gene editing techniques, especially CRISPR/Cas systems, have emerged as powerful tools for modifying genetic information ...
Zheng Yuan
doaj   +1 more source

Regulation of CRISPR-Associated Genes by Rv1776c (CasR) in Mycobacterium tuberculosis

Biomolecules, 2023
The CRISPR-Cas system is an adaptive immune system for many bacteria and archaea to defend against foreign nucleic acid invasion, and this system is conserved in the genome of M. tuberculosis (Mtb).
Wenping Wei, Xiaofang Jiang, Li Zhang, Yunjun Yan, Jinyong Yan, Li Xu, Chun-Hui Gao, Min Yang   +7 more
doaj   +1 more source

CRISPR/Cas-Based Diagnostics in Agricultural Applications

, 2023
Pests and disease-causing pathogens frequently impede agricultural production. An early and efficient diagnostic tool is crucial for effective disease management.
Nguyen, Nam-Trung, Alam, Mobashwer, Shiddiky, Muhammad JA, Tanny, Tanzena, Tanzena Tanny, Narshone Soda, Muhammad J. A. Shiddiky, Sallam, Mohamed, Soda, Narshone, Nam-Trung Nguyen, Mobashwer Alam, Mohamed Sallam   +11 more
core   +1 more source