Results 81 to 90 of about 75,041 (301)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

From Origin to the Present: Establishment, Mechanism, Evolutions and Biomedical Applications of the CRISPR/Cas-Based Macromolecular System in Brief

Molecules
Advancements in biological and medical science are intricately linked to the biological central dogma. In recent years, gene editing techniques, especially CRISPR/Cas systems, have emerged as powerful tools for modifying genetic information ...
Zheng Yuan
doaj   +1 more source

The Involvement of the csy1 Gene in the Antimicrobial Resistance of Acinetobacter baumannii

Frontiers in Medicine, 2022
Acinetobacter baumannii is an important, opportunistic nosocomial pathogen that causes a variety of nosocomial infections, and whose drug resistance rate has increased in recent years.
Tingting Guo, Tingting Guo, Tingting Guo, Xiaoli Sun, Mengying Li, Mengying Li, Yuhang Wang, Hongmei Jiao, Guocai Li, Guocai Li, Guocai Li   +10 more
doaj   +1 more source

CRISPR/Cas-based screening of long non-coding RNAs (lncRNAs) in macrophages with an NF-κB reporter. [PDF]

, 2017
The innate immune system protects against infections by initiating an inducible inflammatory response. NF-κB is one of the critical transcription factors controlling this complex response, but some aspects of its regulation remain unclear.
Carpenter, Susan, Covarrubias, Sergio, Fong, Nicholas, Hanley, Nicole, Katzman, Sol, McManus, Michael T, Robinson, Elektra K, Shapleigh, Barbara, Vollmers, Apple   +8 more
core   +1 more source

CRISPR-Cas systems for diagnosing infectious diseases

Methods, 2022
Infectious diseases are a global health problem affecting billions of people. Developing rapid and sensitive diagnostic tools is key for successful patient management and curbing disease spread. Currently available diagnostics are very specific and sensitive but time-consuming and require expensive laboratory settings and well-trained personnel; thus ...
Kostyusheva, Anastasiya, Brezgin, Sergey, Babin, Yurii, Vasilyeva, Irina, Glebe, Dieter, Kostyushev, Dmitry, Chulanov, Vladimir   +6 more
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Nonviral Delivery of CRISPR/Cas Systems in mRNA Format

Advanced NanoBiomed Research, 2022
The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated (Cas) genome editing system provides a powerful toolbox for genetic engineering.
Zhen Liu, Zhenghua Li, Bin Li
doaj   +1 more source

EspB and HtpG interact with the type III-A CRISPR/Cas system of Mycobacterium tuberculosis

Frontiers in Molecular Biosciences, 2023
Introduction:Mycobacterium tuberculosis (MTB) has a type III-A clustered regularly interspaced short palindromic repeat/CRISPR-associated protein (CRISPR/Cas) system consisting of a Csm1-5 and CRISPR RNA (crRNA) complex involved in the defense against ...
Mingmin Shi, Mingmin Shi, Hongtai Zhang, Joy Fleming, Wenjing Wei, Hong Chen, Xiaowei Dai, Yi Liu, Chuanyou Li, Fanlei Ran, Zhilong Wu, Yaguo Wang, Xilin Zhang, Huizhi Zhang, Lijun Bi, Lijun Bi   +15 more
doaj   +1 more source

Use of CRISPR/Cas system in genome-editing [PDF]

, 2013
CRISPR/Cas sustav u prokariota i arheja igra važnu ulogu u obrani od infektivnih čestica. Izučavanjem principa rada CRISPR/Cas sustava ustanovljeno je da se može iskoristiti u uređivanju kako prokariotskog tako i eukariotskog genoma.
Stojanović, Mario
core   +2 more sources

Modulating signaling networks by CRISPR/Cas9-mediated transposable element insertion [PDF]

, 2018
In a recent past, transposable elements (TEs) were referred to as selfish genetic components only capable of copying themselves with the aim of increasing the odds of being inherited.
A Bolotin, A Burt, A Hammond, AP Lorenzetti, B McClintock, BA Castilho, C Feschotte, C Feschotte, C Feschotte, C Kettlun, C Lu, C Ye, CN Hancock, DBT Cox, DJ Garfinkel, F Palazzoli, FA Ran, FJM Mojica, G Feng, G Mai, G Yang, H Kuang, H Mao, HT Dong, IK Jordan, J Hou, J Li, J Paszkowski, JA Doudna, JB Owens, JD Hollister, JE DiCarlo, JI Qüesta, JK Baillie, JM Casacuberta, K Kikuchi, K Naito, K Naito, K Shirasawa, KD Kim, KM Esvelt, KS Makarova, L Bortesi, L Cong, LC Li, LM Vaschetto, Luis María Vaschetto, M Cowley, M Jinek, M Momose, M Patel, M Szabo, M Turner, N Buchon, N Jiang, N Jiang, N Jiang, Q Zhang, R Barrangou, R Jansen, RM Walsh, SD Molyneux, SR Wessler, SR Yant, T Mourier, T Sakuma, T Singer, VM Gantz, W Matsunaga, WC Lai, X Li, X Li, X Lin, X Shan, Y Ishino, Y Yan, ZN Adelman   +76 more
core   +1 more source