Results 71 to 80 of about 216,867 (346)

Rewriting Human History and Empowering Indigenous Communities with Genome Editing Tools. [PDF]

, 2020
Appropriate empirical-based evidence and detailed theoretical considerations should be used for evolutionary explanations of phenotypic variation observed in the field of human population genetics (especially Indigenous populations). Investigators within
Fox, Keolu, Komor, Alexis C, Rallapalli, Kartik Lakshmi   +2 more
core   +2 more sources

SnapShot: Class 1 CRISPR-Cas Systems

Cell, 2017
Class 1 CRISPR-Cas systems are characterized by effector modules consisting of multiple subunits. Class 1 systems comprise about 90% of all CRISPR-Cas loci identified in bacteria and archaea and can target both DNA and RNA.
Kira S, Makarova, Feng, Zhang, Eugene V, Koonin   +2 more
openaire   +2 more sources

Phylogenetic Distribution of CRISPR-Cas Systems in Antibiotic-Resistant Pseudomonas aeruginosa

mBio, 2015
Pseudomonas aeruginosa is an antibiotic-refractory pathogen with a large genome and extensive genotypic diversity. Historically, P. aeruginosa has been a major model system for understanding the molecular mechanisms underlying type I clustered regularly ...
Alex van Belkum, Leah B. Soriaga, Matthew C. LaFave, Srividya Akella, Jean-Baptiste Veyrieras, E. Magda Barbu, Dee Shortridge, Bernadette Blanc, Gregory Hannum, Gilles Zambardi, Kristofer Miller, Mark C. Enright, Nathalie Mugnier, Daniel Brami, Stéphane Schicklin, Martina Felderman, Ariel S. Schwartz, Toby H. Richardson, Todd C. Peterson, Bolyn Hubby, Kyle C. Cady   +20 more
doaj   +1 more source

Epidemiological and evolutionary consequences of different types of CRISPR-Cas systems.

PLoS Computational Biology, 2022
Bacteria have adaptive immunity against viruses (phages) in the form of CRISPR-Cas immune systems. Currently, 6 types of CRISPR-Cas systems are known and the molecular study of three of these has revealed important molecular differences. It is unknown if
Hélène Chabas, Viktor Müller, Sebastian Bonhoeffer, Roland R Regoes   +3 more
doaj   +1 more source

CRISPR/Cas systems: Delivery and application in gene therapy

Frontiers in Bioengineering and Biotechnology, 2022
The CRISPR/Cas systems in prokaryotes such as bacteria and archaea are the adaptive immune system to prevent infection from viruses, phages, or other foreign substances. When viruses or phages first invade the bacteria, Cas proteins recognize and cut the
Jie Huang, Yitong Zhou, Jie Li, Aiping Lu, Aiping Lu, Aiping Lu, Chao Liang, Chao Liang, Chao Liang   +8 more
doaj   +1 more source

The physicist's guide to one of biotechnology's hottest new topics: CRISPR-Cas

, 2018
Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated proteins (Cas) constitute a multi-functional, constantly evolving immune system in bacteria and archaea cells.
Bonomo, Melia E., Deem, Michael W.
core   +1 more source

Applications of CRISPR–Cas systems in neuroscience [PDF]

, 2016
Genome-editing tools, and in particular those based on CRISPR-Cas (clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated protein) systems, are accelerating the pace of biological research and enabling targeted genetic ...
A Bolotin, A Fire, A Geling, A Plessis, A Xiao, A Zeisel, AJ Wood, AM Geurts, AN Shah, AW Chan, AY Cheung, B Chen, B Pardo, B Zetsche, B Zetsche, C Burger, C Pak, C Straub, D Kim, D Maddalo, D St Johnston, DB Cox, DC van Gent, E Deltcheva, E Sasaki, EA Brenowitz, EB Lewis, EE Patton, EM Jorgensen, F Liang, F Soldner, F Zhang, FA Ran, FA Ran, FD Urnov, Feng Zhang, G Gasiunas, G Murlidharan, GP Flowers, H Akil, H Liu, H Wang, H Xia, HB Kordasiewicz, I Harel, I Jeon, IB Hilton, ID Carbery, IE Clark, J Boch, J Fishman-Lobell, J Fishman-Lobell, J Morton, J Peters, JA Harris, JA Zuris, JC Belmonte, JC Miller, JD Hommel, JD Sander, JD Sander, JD Sweatt, JE Garneau, JL Bessereau, JM Taymans, KJ Beumer, KR Thomas, KS Makarova, KY Kim, L Cong, L Cooley, L Swiech, LA Gilbert, LE Dow, LE Jao, LR Polstein, LS Qi, M Bibikova, M Bibikova, M Christian, M Garriga-Canut, M Jinek, M Maresca, M Zuckermann, Matthias Heidenreich, MC Marchetto, MJ Moscou, N Gaiano, N Rudin, N Wittenburg, NA Kearns, P Essletzbichler, P Mali, P Mali, P Qiu, P Rouet, P Rouet, PD Hsu, R Barrangou, RA Smith, RB Blasco, RD Johnson, RJ Platt, RR Beerli, S Incontro, S Konermann, S Konermann, S Oddo, SD Ryan, SH Yang, SM Elbashir, SQ Tsai, T Katsuyama, T Yagi, TO Auer, VM Bedell, Y Doyon, Y Fu, Y Niu, YG Kim, Z Shen   +120 more
core   +1 more source

The structural biology of CRISPR-Cas systems [PDF]

Current Opinion in Structural Biology, 2015
Prokaryotic CRISPR-Cas genomic loci encode RNA-mediated adaptive immune systems that bear some functional similarities with eukaryotic RNA interference. Acquired and heritable immunity against bacteriophage and plasmids begins with integration of ∼30 base pair foreign DNA sequences into the host genome.
Jiang, Fuguo, Doudna, Jennifer A
openaire   +5 more sources

CRISPR Content Correlates with the Pathogenic Potential of Escherichia coli [PDF]

, 2015
Guide RNA molecules (crRNA) produced from clustered regularly interspaced short palindromic repeat (CRISPR) arrays, altogether with effector proteins (Cas) encoded by cognate cas (CRISPR associated) genes, mount an interference mechanism (CRISPR-Cas ...
Almendros, Cristóbal, García-Gutiérrez, Enriqueta, García-Martínez, Jesús, Guzmán, Noemí M., Mojica, Francisco J.M.   +4 more
core   +4 more sources

Features of CRISPR-Cas Regulation Key to Highly Efficient and Temporally-Specific crRNA Production

Frontiers in Microbiology, 2017
Bacterial immune systems, such as CRISPR-Cas or restriction-modification (R-M) systems, affect bacterial pathogenicity and antibiotic resistance by modulating horizontal gene flow.
Andjela Rodic, Andjela Rodic, Bojana Blagojevic, Magdalena Djordjevic, Konstantin Severinov, Konstantin Severinov, Marko Djordjevic   +6 more
doaj   +1 more source