Results 51 to 60 of about 12,586 (283)

Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases

Advanced Science, EarlyView.
There is no drug targeting the NLRP3 inflammasome that has been approved for use in clinical settings. Ciclopirox olamine (CPX), an antifungal agent approved by the US Food and Drug Administration (FDA), is identified as a specific and potent NLRP3 inflammasome inhibitor. CPX targets the NACHT domain of NLRP3 at Y381 to impair NLRP3 oligomerization and
Xinyu Xia, Hui You, Ke Zhang, Hui Jiang, Hongping Liu, Lianghua Liu, Aijie Zhang, You Zhou   +7 more
wiley   +1 more source

Native-speakerism and the complexity of personal experience: A duoethnographic study

Cogent Education, 2016
This paper presents a duoethnographic study into the effects of native-speakerism on the professional lives of two English language teachers, one “native”, and one “non-native speaker” of English. The goal of the study was to build on and extend existing
Robert J. Lowe, Marek Kiczkowiak
doaj   +1 more source

Towards a Critical Applied Linguistics for the 1990s [PDF]

Issues in Applied Linguistics, 1990
7 Editorial REFERENCES Banhes, R^ (1986). In Bruissement de la langue [Rustle of language] (DD 97-103I Transiais by R. Howard. New York? Hill & Wang. Bickexton, D. (1973). The nature of the creole continuum. Language 49 3 640 f>f>Q Eliot. T.S. (1943) Lulle Cidding. London: Faber & Faber James.
openaire   +3 more sources

CRITICAL ANALYSIS OF A UNIT OF A TEXTBOOK USING CRITICAL APPLIED LINGUISTICS AND CRITICAL DISCOURSE ANALYSIS [PDF]

, 2016
New Interchange 3 (Richards, 2005) is one of textbooks used for English language teaching and learning (ELT), which covers English macro skills and language aspects. However, a question of appropriateness for ELT is raised.
Agustina, Rina
core  

From Label‐Free Multiphoton Imaging to Pathological Reports: A Vision‐Language Breast Cancer Margin Pathological Diagnosis System

Advanced Science, EarlyView.
MarginPath is a novel vision‐language system that automates breast cancer margin assessment using a single label‐free multiphoton microscopy image. By integrating tumor‐associated collagen signatures with virtual H&E imaging, it generates accurate margin heatmaps and comprehensive diagnostic reports.
Shu Wang, Jingze Su, Xiahui Han, Deyong Kang, Xiao Zhang, Fei Xu, Changzu Liu, Junlin Pan, Xingfu Wang, Qiaohui Zhan, Aimin Wang, Feng Huang, Heping Cheng, Wenxi Liu, Ruolan Lin, Jianxin Chen   +15 more
wiley   +1 more source

INTERSECTIONS BETWEEN APPLIED LINGUISTICS AND LITERACY RESEARCH: EPISTEMOLOGICAL, THEORETICAL, AND METHODOLOGICAL ISSUES

Matraga, 2015
The paper discusses three aspects in New Literacies Studies research in Brazil, as developed by researchers from an Applied Linguistics perspective. This perspective contributes to determine epistemological, theoretical, and methodological issues in ...
Angela Kleiman, Paula Baracat De Grande
doaj   +1 more source

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

Advanced Science, EarlyView.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak, Juliane Tschuck, Stefanie A. I. Weiß, Daniel Kaemena, Karolin Klimm, Ana Galhoz, Larissa Ringelstetter, Myles Fennell, Juliane Merl‐Pham, Anna Artati, Stefanie Strasser, Ralph Garippa, Michael Witting, Hans Zischka, Joel A. Schick, Stefanie M. Hauck, Michael P. Menden, Michelle Vincendeau, Brent R. Stockwell, Kamyar Hadian   +19 more
wiley   +1 more source

CEBPG‐Mediated Palmitic Acid Adaptation of Cancer‐Associated Fibroblasts Drives Metastasis of Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study reveals a metabolic signaling axis in the OSCC microenvironment where palmitic acid (PA) drives the activation of CAFs. PA uptake triggers CEBPG‐dependent epigenetic remodeling to upregulate ERN1 and TMBIM6, thereby mitigating ER stress. This adaptive program sustains CAF survival and the pro‐metastatic phenotype, establishing this pathway ...
Yiling Duan, Yitong Li, Yufei Wu, Xiao Yang, Rui Li, Hui Zhao, Zhengjun Shang   +6 more
wiley   +1 more source

The Applied Linguistics and Peacebuilding in Colombian English Teachers’ Master’s Theses

Colombian Applied Linguistics Journal
  This article presents a review from a social and critical perspective of applied linguistics (AL) within English language teaching (ELT) and how it relates to the notion of education for peace in Colombia.
Alvaro Quintero-Polo, Carmen Helena Guerrero-Nieto   +1 more
doaj   +1 more source

CONCEPTUAL VALUES AND PRIORITIES: STABILITY VERSUS CHANGES (BASED ON DEFORMED PROVERBS)

Записки з українського мовознавства, 2019
Contemporary “stormy” changes in global and national political economic, social, societies are causing changes in traditional, archaic ideologies, outlooks, mentalities which are definitely reflected in languages, particularly in phraseology.
Н. М. Філіппова
doaj   +1 more source