Results 111 to 120 of about 12,929,549 (289)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Finite groups with given properties of critical subgroups [PDF]

, 2013
Работа посвящена изучению конечных групп с заданными свойствами критических подгрупп.This work is devoted to the study of finite groups with given properties of critical ...
Семенчук, В. Н., Велесницкий, В. Ф.   +1 more
core   +2 more sources

Critical groups estimates for a soliton type problem

, 2001
This work is concerned about applicability of Morse Theory to a class of quasilinear problems whose solutions are critical points of a functional defined on a Sobolev Banach space which has not a Hilbert structure.
VANNELLA, Giuseppina, Giuseppina Vannella   +1 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Oxygen Functional Groups on MWCNT Surface as Critical Factor Boosting T2 Relaxation Rate of Water Protons: Towards Improved CNT-Based Contrast Agents

International Journal of Nanomedicine, 2020
Mateusz Michał Tomczyk,1 Sławomir Boncel,1 Artur Herman,2 Tomasz Krawczyk,1 Agata Jakóbik-Kolon,1 Mirosława Pawlyta,3 Maciej Krzywiecki,4 Artur Chrobak,5 Masafumi Minoshima,6 Fuminori Sugihara,7 Kazuya Kikuchi,6 Nikodem Kuźnik1 1Faculty of ...
Tomczyk MM, Boncel S, Herman A, Krawczyk T, Jakóbik-Kolon A, Pawlyta M, Krzywiecki M, Chrobak A, Minoshima M, Sugihara F, Kikuchi K, Kuźnik N   +11 more
doaj  

Research of Intersection Groups Optimization Control Method Based on Critical Path Identification

MATEC Web of Conferences, 2018
An optimal intersection groups control method based on critical path identification is proposed. The control algorithm uses a binary search to gradually determine the scope of the intersection groups, uses the duality method to express the intersection ...
Liu Ying, Fang Lv, Shen Jiayan
doaj   +1 more source

Evidence-based teaching: A critical overview for enquiring teachers.

, 2018
This book provides a critical overview of evidence-based teaching, with balanced and reflective consideration given to arguments supporting various approaches to increasing the use of evidence in teaching and arguments that raise doubts about, or ...
Poultney, Val, Philpott, Carey
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Multiple solutions to asymmetric semilinear elliptic problems via Morse theory

Electronic Journal of Differential Equations, 2014
In this article we study the existence of solutions to the problem $$\displylines{ -\Delta u = g(x,u) \quad \text{in } \Omega; \cr u = 0 \quad\text{on } \partial\Omega, }$$ where $\Omega$ is a smooth bounded domain in $\mathbb{R}^N$ $(N\geq 2)$
Leandro L. Recova, Adolfo J. Rumbos
doaj