Results 121 to 130 of about 4,412 (273)
A Critical Comparative Evaluation of English Course Books in EFL Context
, 2014 Choosing an English course book which suits students in EFL/ESL settings is always a contentious issue for practitioners. This study is an investigation into the comparative critical evaluation of New Interchange Intro and New Headway Pre-intermediate ...
Roshan, Saeed
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
, 2013 Roundabouts have been continuously constructed in the U.S. in recent years, as studies have shown their capability of reducing crash risk and severity when compared with signalized intersections.
Li, Zhixia, +4 more
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
IEEE AccessAs electric power systems increasingly integrate Renewable Energy Sources (RESs), the consequent reduction in system inertia has heightened their sensitivity to disturbances, such as sudden load changes. This issue is especially relevant in railway power
Teeraphon Phophongviwat +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
IMPLEMENTATION OF CAPACITY CALCULATION IN THE SECTIONS WITH AN INTERMEDIATE JUNCTION IN IS KANGO
Perner’s Contacts, 2012 This article deals with the specification of new methodology of capacity calculation in the crossing or overtaking sections with one or more junctions as well as with a concrete implementation of the methodology as standalone computing unit within ...
Petr Veselý, Pavel Krýže
doaj
The Problem of Resolving Train Movement Conflicts in a Traffic Management System
Applied SciencesThis article addresses selected aspects of designing a Traffic Management System (TMS) for the railway component of Poland’s Central Communication Port (CPK) project.
Janusz Szkopiński +2 more
doaj +1 more source