Results 111 to 120 of about 4,412 (273)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Civil and Environmental EngineeringMotorcyclist–pedestrian conflicts at unsignalized mid-block crosswalks represent a critical safety concern, particularly in urban areas of developing countries where motorcycles account for a substantial proportion of the vehicle fleet.
Sutantaviboon Tanawan +1 more
doaj +1 more source
Transportation Research Interdisciplinary PerspectivesA sound understanding of driving behaviour is indispensable for properly modelling and predicting traffic dynamics, and accurately evaluating its impact on efficiency, safety, energy consumption, and the environment.
Yasir Ali, Anshuman Sharma, Zuduo Zheng
doaj +1 more source
Headway modelling for traffic load assessment of short to medium span bridges
, 2010 Site-specific assessment of the loading to which existing bridges are subject has considerable potential for saving on rehabilitation and replacement costs of the bridge stock.
O\u27Brien, Eugene J., Caprani, Colin C.
core
Capacity Analysis of Single-Lane Roundabouts in The State of Qatar [PDF]
, 2020 This master thesis presents capacity analysis of Single-Lane roundabouts in the State of Qatar. The aim of this paper is to update Qatar highway manual, by developing a new capacity model using empirical data collected from directly the field for a ...
Albeitjali, Naeem Nasser Naim
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Space for cycling: A scoping review of recent evidence on the dynamic envelope for bicycle riding
Transportation Research Interdisciplinary PerspectivesHow much space does it take to ride a bicycle? The aim of this study was to answer this interdisciplinary question as depending on perspective, this could be a technical, social or political question.
Robbie Napper, Tyrell Siew, Yi Jing Ang
doaj +1 more source
CRITICAL HEADWAY AT UNSIGNALIZED INTERSECTIONS - LITERATURE REVIEW
INTERNATIONAL JOURNAL FOR TRAFFIC AND TRANSPORT ENGINEERING, 2021 openaire +1 more source