Results 91 to 100 of about 3,761 (238)
Transportation Research Interdisciplinary PerspectivesA sound understanding of driving behaviour is indispensable for properly modelling and predicting traffic dynamics, and accurately evaluating its impact on efficiency, safety, energy consumption, and the environment.
Yasir Ali, Anshuman Sharma, Zuduo Zheng
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Civil and Environmental EngineeringMotorcyclist–pedestrian conflicts at unsignalized mid-block crosswalks represent a critical safety concern, particularly in urban areas of developing countries where motorcycles account for a substantial proportion of the vehicle fleet.
Sutantaviboon Tanawan +1 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Space for cycling: A scoping review of recent evidence on the dynamic envelope for bicycle riding
Transportation Research Interdisciplinary PerspectivesHow much space does it take to ride a bicycle? The aim of this study was to answer this interdisciplinary question as depending on perspective, this could be a technical, social or political question.
Robbie Napper, Tyrell Siew, Yi Jing Ang
doaj +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
IEEE AccessAs electric power systems increasingly integrate Renewable Energy Sources (RESs), the consequent reduction in system inertia has heightened their sensitivity to disturbances, such as sudden load changes. This issue is especially relevant in railway power
Teeraphon Phophongviwat +2 more
doaj +1 more source