Results 101 to 110 of about 4,412 (273)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Gap acceptance parameters for HCM 2010 roundabout capacity model applications in Italy

, 2013
This paper deals with the field data observation and successive application of estimation procedures in order to estimate follow-up headway and critical headway at roundabouts. Average follow-up headway and average critical headway are two key parameters
A. Gazzarri, A. Pratelli, Martello, Michael T., Alessandra Gazzarri, Reginald R. Souleyrette, PRATELLI, ANTONIO, Gazzarri, A., M. T. Martello, Souleyrette, Reginald R., R. R. Souleyrette, Michael T. Martello   +10 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Safety in the Face of Uncertainty

, 2015
This article proposes a safety check extension to Adaptive Cruise Control systems where the critical headway time is estimated in real-time. This critical headway time estimate enables automated reaction to crisis circumstances such as when a preceding ...
Willigen, W.H. van, Haasdijk, E., Nunen, E. van, Haasdijk, E.W., Nunen, Ellen, Kester, L.J.H.M., van Willigen, W.H., Kester, Leon   +7 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

DEVELOPMENT OF METHODOLOGY FOR CAPACITY CALCULATION IN THE SECTIONS WITH AN INTERMEDIATE JUNCTION

Perner’s Contacts, 2011
This article deals with the methodology of capacity calculation in the crossing or overtaking sections with one or more junctions. The basic methodology adumbrated in (1) is developed with emphasis on thorough specification of input data and the process
Petr Veselý, Petr Krýže
doaj  

Standardization of capacity unit for headway-based rail capacity analysis

, 2015
Determining the required capacity upgrades to accommodate future demand is a critical process in assisting public and private financing of capacity investments.
Lin, Yi-Ju, Liu, Yun-Hsuan, Lai, Yung-Cheng   +2 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Headway distribution effect on gap-acceptance behavior at roundabouts: Driving simulator experiments in a case study

, 2018
The main goal of this work is the analysis of gap-acceptance behavior at roundabouts under different types of headway distribution in the circulating stream through driving simulator experiments.
C. Meneguzzer, R. Rossi, M. Gastaldi
core   +1 more source

Critical review of the English book “New Headway-Beginner” as a curriculum for Iraqi EFL learners’ non-departmental undergraduates

مجلة واسط للعلوم الانسانية
The suitable choice of an English coursebook for EFL learners is important to provide learners with opportunities to receive and practice the language both in and out of the classroom. This research aims to evaluate  “New Headway" textbook to determine its suitability as a curriculum in relation to the objectives of the teaching program and the ...
openaire   +2 more sources