Results 81 to 90 of about 4,412 (273)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
IEEE AccessThis paper introduces a novel Real-Time Model Predictive Control (MPC) framework for automatic train regulation in complex metro lines featuring bifurcations, short-turning operations, and continuous communication systems (CBTC or ERTMS), enabling real ...
Alvaro Cidoncha +4 more
doaj +1 more source
Promet (Zagreb), 2004 The problem of minor vehicles crossing or merging into themajor stream at unsignalized priority-controlled intersections iswell-known. Numerous solutions involve various assumptionsconcerning the major headway distributions, number of majorlanes ...
Tomaž Tolazzi
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Modeling same-direction two-lane traffic for bridge loading
, 2011 Many highway bridges carry traffic in two same-direction lanes, and modeling the traffic loading on such bridges has been the subject of numerous studies.
Bernard Enright +5 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
A new approach to designing lateral collision warning systems
, 2007 According to the National Highway Traffic Safety Administration (NHTSA), more than 43% of all fatal accidents reported in 2001 involved a lane or road departure.
Stanton, Neville A +11 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Research on Vehicle Fatigue Load Spectrum of Highway Bridges Based on Weigh-in-Motion Data
BuildingsEstablishing an accurate vehicle fatigue load spectrum is a critical prerequisite for fatigue life analysis and design of highway bridges. However, the time-varying and regional characteristics of vehicle loads pose significant challenges to achieving ...
Ruisheng Feng +5 more
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source