Results 1 to 10 of about 510,057 (296)

Chrononutrition in Critical Illness. [PDF]

Nutr Rev
Abstract Circadian rhythms in humans are biological rhythms that regulate various physiological processes within a 24-hour time frame. Critical illness can disrupt the circadian rhythm, as can environmental and clinical factors, including altered light exposure, organ replacement therapies, disrupted sleep–wake cycles, noise, continuous ...
Sagun E, Akyol A, Kaymak C.
europepmc   +3 more sources

Redefining critical illness

Nature Medicine, 2022
Research and practice in critical care medicine have long been defined by syndromes, which, despite being clinically recognizable entities, are, in fact, loose amalgams of heterogeneous states that may respond differently to therapy. Mounting translational evidence-supported by research on respiratory failure due to severe acute respiratory syndrome ...
Maslove, David M, Tang, Benjamin, Shankar-Hari, Manu, Lawler, Patrick R, Angus, Derek C, Baillie, J Kenneth, Baron, Rebecca M, Bauer, Michael, Buchman, Timothy G, Calfee, Carolyn S, Dos Santos, Claudia C, Giamarellos-Bourboulis, Evangelos J, Gordon, Anthony C, Kellum, John A, Knight, Julian C, Leligdowicz, Aleksandra, McAuley, Daniel F, McLean, Anthony S, Menon, David K, Meyer, Nuala J, Moldawer, Lyle L, Reddy, Kiran, Reilly, John P, Russell, James A, Sevransky, Jonathan E, Seymour, Christopher W, Shapiro, Nathan I, Singer, Mervyn, Summers, Charlotte, Sweeney, Timothy E, Thompson, B Taylor, van der Poll, Tom, Venkatesh, Balasubramanian, Walley, Keith R, Walsh, Timothy S, Ware, Lorraine B, Wong, Hector R, Zador, Zsolt E, Marshall, John C   +38 more
openaire   +10 more sources

Effect of propranolol and clonidine after severe traumatic brain injury: a pilot randomized clinical trial

Critical Care, 2023
Objective To evaluate the safety, feasibility, and efficacy of combined adrenergic blockade with propranolol and clonidine in patients with severe traumatic brain injury (TBI).
Mina F. Nordness, Amelia W. Maiga, Laura D. Wilson, Tatsuki Koyama, Erika L. Rivera, Shayan Rakhit, Michael de Riesthal, Cari L. Motuzas, Madison R. Cook, Deepak K. Gupta, James C. Jackson, Shawniqua Williams Roberson, William J. Meurer, Roger J. Lewis, Geoffrey T. Manley, Pratik P. Pandharipande, Mayur B. Patel   +16 more
doaj   +1 more source

Instruments Assessing Cognitive Impairment in Survivors of Critical Illness and Reporting of Race Norms: A Systematic Review

Critical Care Explorations, 2022
OBJECTIVE:. To conduct a systematic review to summarize cognitive instruments being used in long-term outcome studies of survivors of adult critical illness, as well as evaluate whether these measures are reported as using patient demographic norms ...
Rameela Raman, PhD, Spencer J. DesAutels, MLIS, Alana M. Lauck, MS, Alexa M. Scher, BA, Rachel L. Walden, MLIS, Amy L. Kiehl, MA, Erin M. Collar, MPH, E. Wesley Ely, MD, MPH, Pratik P. Pandharipande, MD, MSCI, James C. Jackson, PsyD   +9 more
doaj   +1 more source

Heterogeneity in design and analysis of ICU delirium randomized trials: a systematic review

Trials, 2021
Background There is a growing number of randomized controlled trials (RCTs) evaluating interventions to prevent or treat delirium in the intensive care unit (ICU).
Elizabeth Colantuoni, Mounica Koneru, Narjes Akhlaghi, Ximin Li, Mohamed D. Hashem, Victor D. Dinglas, Karin J. Neufeld, Michael O. Harhay, Dale M. Needham   +8 more
doaj   +1 more source

Influence of Limonin on Malignant Biological Behavior of Non-small Cell Lung Cancer Cells by Regulating JAK2/STAT3 Signaling Pathway

Zhongliu Fangzhi Yanjiu, 2023
Objective To investigate the influence of limonin on the malignant biological behavior of non-small cell lung cancer (NSCLC) cells by regulating the protein tyrosine kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling ...
HU Huijie, ZHENG Xiaolu, LEI Lifeng
doaj   +1 more source

Voluntary running exercise protects against sepsis-induced early inflammatory and pro-coagulant responses in aged mice

Critical Care, 2017
Background Despite many animal studies and clinical trials, mortality in sepsis remains high. This may be due to the fact that most experimental studies of sepsis employ young animals, whereas the majority of septic patients are elderly (60 − 70 years ...
Karel Tyml, Scott Swarbreck, Cynthia Pape, Dan Secor, James Koropatnick, Qingping Feng, Ruud A. W. Veldhuizen, Sean E. Gill   +7 more
doaj   +1 more source

Immunomodulation in the critically ill [PDF]

British Journal of Anaesthesia, 2009
Immunotherapy in the critically ill is an appealing notion because of the apparent abnormal immune and inflammatory responses seen in so many patients. The administration of a medication that could alter immune responses and decrease mortality in patients with sepsis could represent a 'magic bullet'.
Webster, N.R., Galley, H.F.
openaire   +2 more sources

Antimicrobial exposure and the risk of delirium in critically ill patients

Critical Care, 2018
Background Prior retrospective cross-sectional work has associated antimicrobials with a non-specific phrase: encephalopathy without seizures. The purpose of this study is to determine whether different classes of antimicrobials have differential ...
Jessica J. Grahl, Joanna L. Stollings, Shayan Rakhit, Anna K. Person, Li Wang, Jennifer L. Thompson, Pratik P. Pandharipande, E. Wesley Ely, Mayur B. Patel   +8 more
doaj   +1 more source

COVID-19: ICU delirium management during SARS-CoV-2 pandemic

Critical Care, 2020
The novel coronavirus, SARS-CoV-2-causing Coronavirus Disease 19 (COVID-19), emerged as a public health threat in December 2019 and was declared a pandemic by the World Health Organization in March 2020.
Katarzyna Kotfis, Shawniqua Williams Roberson, Jo Ellen Wilson, Wojciech Dabrowski, Brenda T. Pun, E. Wesley Ely   +5 more
doaj   +1 more source