Results 21 to 30 of about 895,518 (315)
Vascular endothelial‐cadherin as a marker of endothelial injury in preclinical Alzheimer disease
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1926-1940, December 2022., 2022 Abstract Objective Endothelial dysfunction is an early and prevalent pathology in Alzheimer disease (AD). We here investigate the value of vascular endothelial‐cadherin (VEC) as a cerebrospinal fluid (CSF) marker of endothelial injury in preclinical AD.
Rawan Tarawneh +5 more
wiley +1 more source
Heterogeneity in design and analysis of ICU delirium randomized trials: a systematic review
Trials, 2021 Background There is a growing number of randomized controlled trials (RCTs) evaluating interventions to prevent or treat delirium in the intensive care unit (ICU).
Elizabeth Colantuoni +8 more
doaj +1 more source
COVID‐19 and the risk of Alzheimer's disease, amyotrophic lateral sclerosis, and multiple sclerosis
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1953-1961, December 2022., 2022 Abstract Background The coronavirus disease 2019 (COVID‐19) pandemic has had an unprecedented impact on the healthcare system, economy, and society. Studies have reported that COVID‐19 may cause various neurologic symptoms, including cognitive impairment.
Hanyu Zhang, Zengyuan Zhou
wiley +1 more source
Zhongliu Fangzhi Yanjiu, 2023 Objective To investigate the influence of limonin on the malignant biological behavior of non-small cell lung cancer (NSCLC) cells by regulating the protein tyrosine kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling ...
HU Huijie, ZHENG Xiaolu, LEI Lifeng
doaj +1 more source
The Intestinal Microbiome after Traumatic Injury
Microorganisms, 2023 The intestinal microbiome plays a critical role in host immune function and homeostasis. Patients suffering from—as well as models representing—multiple traumatic injuries, isolated organ system trauma, and various severities of traumatic injury have ...
Jennifer A. Munley +6 more
doaj +1 more source
Asymptotics for the rotating fluids and primitive systems with large ill-prepared initial data in critical spaces [PDF]
Tunisian J. Math. 5 (2023) 171-213, 2022 In this article we study the lifespan and asymptotics (in the large rotation and stratification regime) for the Primitive system for highly ill-prepared initial data in critical spaces. Compared to our previous works, we simplified the proof and made it adaptable to the Rotating fluids system with highly ill-prepared initial data decomposed as a sum of
arxiv +1 more source
Immunomodulation in the critically ill [PDF]
British Journal of Anaesthesia, 2009 Immunotherapy in the critically ill is an appealing notion because of the apparent abnormal immune and inflammatory responses seen in so many patients. The administration of a medication that could alter immune responses and decrease mortality in patients with sepsis could represent a 'magic bullet'.
Helen F. Galley, Nigel R. Webster
openaire +3 more sources
COVID-19: ICU delirium management during SARS-CoV-2 pandemic
Critical Care, 2020 The novel coronavirus, SARS-CoV-2-causing Coronavirus Disease 19 (COVID-19), emerged as a public health threat in December 2019 and was declared a pandemic by the World Health Organization in March 2020.
Katarzyna Kotfis +5 more
doaj +1 more source
Critical Care, 2017 Background Despite many animal studies and clinical trials, mortality in sepsis remains high. This may be due to the fact that most experimental studies of sepsis employ young animals, whereas the majority of septic patients are elderly (60 − 70 years ...
Karel Tyml +7 more
doaj +1 more source
A Proteinase 3 Contribution to Juvenile Idiopathic Arthritis-Associated Cartilage Damage
Pathophysiology, 2021 A full understanding of the molecular mechanisms implicated in the etiopathogenesis of juvenile idiopathic arthritis (JIA) is lacking. A critical role for leukocyte proteolytic activity (e.g., elastase and cathepsin G) has been proposed.
Eric K. Patterson +5 more
doaj +1 more source