Results 21 to 30 of about 510,057 (296)

Association between cholinesterase activity and critical illness brain dysfunction

Critical Care, 2022
Background Delirium is a frequent manifestation of acute brain dysfunction and is associated with cognitive impairment. The hypothesized mechanism of brain dysfunction during critical illness is centered on neuroinflammation, regulated in part by the ...
Christopher G. Hughes, Christina S. Boncyk, Benjamin Fedeles, Pratik P. Pandharipande, Wencong Chen, Mayur B. Patel, Nathan E. Brummel, James C. Jackson, Rameela Raman, E. Wesley Ely, Timothy D. Girard   +10 more
doaj   +1 more source

A Transcriptomic Severity Metric That Predicts Clinical Outcomes in Critically Ill Surgical Sepsis Patients

Critical Care Explorations, 2021
OBJECTIVES:. Clinically deployable methods for the rapid and accurate prediction of sepsis severity that could elicit a meaningful change in clinical practice are currently lacking.
Scott C. Brakenridge, MD, Petr Starostik, MD, Gabriella Ghita, PhD, Uros Midic, PhD, Dijoia Darden, MD, Brittany Fenner, MD, James Wacker, MS, Philip A. Efron, MD, Oliver Liesenfeld, MD, Timothy E. Sweeney, MD, PhD, Lyle L. Moldawer, PhD   +10 more
doaj   +1 more source

Dealing with missing delirium assessments in prospective clinical studies of the critically ill: a simulation study and reanalysis of two delirium studies

BMC Medical Research Methodology, 2021
Background In longitudinal critical care studies, researchers may be interested in summarizing an exposure over time and evaluating its association with a long-term outcome. For example, the number of days a patient has delirium (i.e., brain dysfunction)
Rameela Raman, Wencong Chen, Michael O. Harhay, Jennifer L. Thompson, E. Wesley Ely, Pratik P. Pandharipande, Mayur B. Patel   +6 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Procalcitonin in Critical Illness

Critical Care and Resuscitation, 2001
To detail the biology and diagnostic usefulness of serum procalcitonin in critical illness.A review of articles published in peer reviewed journals from 1990 to 2001 and identified through a MEDLINE search on procalcitonin.Procalcitonin (PCT) is a prohormone of calcitonin.
E, O'Connor, B, Venkatesh, J, Lipman, C, Mashongonyika, J, Hall   +4 more
openaire   +2 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Development and validation of a machine learning model to predict early recurrence after surgery in NSCLC patients

Scientific Reports
To develop and validate a machine learning (ML) model for predicting early recurrence (ER) within two years post-surgery in non-small cell lung cancer (NSCLC) patients.
Guo-Yong Lin, Run-Nan Chen, Shun Wu, Zhi-Sen Gao, Xiang-Qiong Guo, Xiao-Hong Zheng, Shu-Zhen Chen   +6 more
doaj   +1 more source

Natural Product Alantolactone Targeting AKR1C1 Suppresses Cell Proliferation and Metastasis in Non-Small-Cell Lung Cancer

Frontiers in Pharmacology, 2022
Non-small-cell lung cancer (NSCLC) is one of the leading causes of cancer-related deaths, characterized by high invasion and metastasis. Aldo-keto reductase family 1 member C1 (AKR1C1) plays an important role in cancer cell proliferation and metastasis ...
Zhiwen Fu, Zhiwen Fu, Shijun Li, Shijun Li, Jinmei Liu, Jinmei Liu, Cong Zhang, Cong Zhang, Chen Jian, Chen Jian, Lulu Wang, Lulu Wang, Yu Zhang, Yu Zhang, Chen Shi, Chen Shi   +15 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

scRNA-seq revealed high stemness epithelial malignant cell clusters and prognostic models of lung adenocarcinoma

Scientific Reports
Lung adenocarcinoma (LUAD) is one of the sole causes of death in lung cancer patients. This study combined with single-cell RNA-seq analysis to identify tumor stem-related prognostic models to predict the prognosis of lung adenocarcinoma, chemotherapy ...
GuoYong Lin, ZhiSen Gao, Shun Wu, JianPing Zheng, XiangQiong Guo, XiaoHong Zheng, RunNan Chen   +6 more
doaj   +1 more source