Results 1 to 10 of about 88,305 (355)
Co-Delivery of Bioengineered Exosomes and Oxygen for Treating Critical Limb Ischemia in Diabetic Mice. [PDF]
ACS Nano, 2023 Diabetic patients with critical limb ischemia face a high rate of limb amputation. Regeneration of the vasculature and skeletal muscles can salvage diseased limbs.
Zhong T, Gao N, Guan Y, Liu Z, Guan J.
europepmc +2 more sources
Vascular Medicine, 2021 Critical limb ischemia (CLI), also known as chronic limbthreatening ischemia (CLTI), is the most severe form of peripheral artery disease (PAD). PAD occurs due to blockages in the leg arteries due to atherosclerosis or plaque build-up.
E. Armstrong, D. Armstrong
semanticscholar +4 more sources
Endothelial Progenitor Cells May Be Related to Major Amputation after Angioplasty in Patients with Critical Limb Ischemia [PDF]
Cells, 2023 Background: Critical limb ischemia represents an advanced stage of peripheral arterial disease. Angioplasty improves blood flow to the limb; however, some patients progress irreversibly to lower limb amputation.
Daniel Santillán-Cortez +15 more
doaj +2 more sources
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 Background The optimal treatment for critical limb ischemia remains controversial owing to conflicting conclusions from previous studies. Methods and Results We obtained administrative claims on Medicare beneficiaries with initial critical limb ischemia ...
Jihad A. Mustapha +6 more
doaj +2 more sources
Critical limb ischemia: current challenges and future prospects
Vascular Health and Risk Management, 2018 Luigi Uccioli,1 Marco Meloni,1 Valentina Izzo,1 Laura Giurato,1 Stefano Merolla,2 Roberto Gandini2 1Department of Systems Medicine, 2Department of Interventional Radiology, Università di Tor Vergata Roma, Rome, Italy Abstract: Critical limb ...
Uccioli L +5 more
doaj +2 more sources
Cell Therapy in Patients with Critical Limb Ischemia [PDF]
Stem Cells International, 2015 Critical limb ischemia (CLI) represents the most advanced stage of peripheral arterial obstructive disease (PAOD) with a severe obstruction of the arteries which markedly reduces blood flow to the extremities and has progressed to the point of severe ...
Rita Compagna +7 more
doaj +4 more sources
Stem-cell therapies in critical limb ischemia [PDF]
The Moldovan Medical Journal, 2021 Background: Due to stimulation of muscular regeneration in ischemic extremities and increasing blood flow, stem cells are considered a promising new strategy for patients with critical limb ischemia (CLI).
Sergiu Visnevschi +3 more
doaj +1 more source
Current Treatment Options in Cardiovascular Medicine, 2010 Critical limb ischemia (CLI), defined as chronic ischemic rest pain, ulcers, or gangrene attributable to objectively proven arterial occlusive disease, is the most advanced form of peripheral arterial disease. Traditionally, open surgical bypass was the only effective treatment strategy for limb revascularization in this patient population.
Schanzer, Andres, Conte, Michael S.
openaire +9 more sources
Vascular Investigation and Therapy, 2021 Critical limb ischemia (CLI) is the most advanced stage of peripheral arterial disease (PAD). Its prognosis is poor, with high rates of limb amputation and cardiovascular mortality.
Romeo Martini, Francesca Ghirardini
doaj +1 more source
Emerging roles of mesenchymal stem cell therapy in patients with critical limb ischemia
Stem cell research & therapeutics, 2022 Critical limb ischemia (CLI), the terminal stage of peripheral arterial disease (PAD), is characterized by an extremely high risk of amputation and vascular issues, resulting in severe morbidity and mortality.
Zeinab Shirbaghaee +3 more
semanticscholar +1 more source