Results 61 to 70 of about 98,922 (352)

Duplex and Angiographic-Assisted Evaluation of Outcomes of Endovascular Embolization after Surgical Deep Vein Arterialization for the Treatment No-Option Critical Limb Ischemia Patients

Diagnostics, 2022
Objective: To report early and mid-term outcomes of the arterialization of the deep venous system in no-option critical limb-threatening ischemia (CLTI) using duplex ultrasound and angiographic evaluation to improve limb perfusion.
Nunzio Montelione, Vincenzo Catanese, Teresa Gabellini, Francesco Alberto Codispoti, Antonio Nenna, Francesco Spinelli, Francesco Stilo   +6 more
doaj   +1 more source

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source

Trends in Hospitalization, Management, and Clinical Outcomes Among Veterans With Critical Limb Ischemia

Circulation. Cardiovascular Interventions, 2020
Supplemental Digital Content is available in the text. Background: Contemporary patterns in management and outcomes of critical limb ischemia among United States veterans are unknown.
A. Mentias, A. Qazi, Kimberly D. McCoy, R. Wallace, M. Vaughan-Sarrazin, S. Girotra   +5 more
semanticscholar   +1 more source

Mesenchymal Stem Cell‐Derived Apoptotic Micro‐Vesicles Repaired Sciatic Nerve Defect by Regulating Early Inflammatory Microenvironment and Promoting Angiogenesis

Advanced Healthcare Materials, EarlyView.
HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu, Yiben Ouyang, Bo Wang, Xiaochun Zhang, Yanjun Guan, Ruichao He, Yuhui Cui, Junli Wang, Qianru Yao, Yixiao Tan, Xiwei Peng, Xing Xiong, Sice Wang, Dongdong Li, Haofeng Cheng, Tianqi Su, Xiaoyang Fu, Jinjuan Zhao, Mingqian Yu, Yi Wang, Jiang Peng, Yu Wang   +21 more
wiley   +1 more source

Endovascular Treatment of Acute Tibioperoneal Trunk Thrombosis. A Clinical Case Report

Креативная хирургия и онкология, 2019
Introduction. Acute limb ischemia is a severe disorder caused by a sharp drop in the arterial perfusion of the limb. It carries a threat to the limb’s function and viability.
D. S. Chigidinova, B. A. Rudenko, A. S. Shanoyan, V. P. Mazaev, F. B. Shukurov   +4 more
doaj   +1 more source

Management of Critical Limb Ischemia [PDF]

Circulation: Cardiovascular Interventions, 2016
Critical limb ischemia (CLI) is a clinical syndrome of ischemic pain at rest or tissue loss, such as nonhealing ulcers or gangrene, related to peripheral artery disease. CLI has a high short-term risk of limb loss and cardiovascular events. Noninvasive or invasive angiography help determine the feasibility and approach to arterial revascularization. An
openaire   +2 more sources

Characterization of an Injectable Poly(vinyl alcohol)‐gelatin Hydrogel for Growth Factor Delivery in an Orthopedic Application

Advanced Healthcare Materials, EarlyView.
This work introduces photo‐crosslinkable tyraminated poly(vinyl alcohol)‐gelatin (PVA‐GT) hydrogels as tunable injectable platforms for tissue engineering and growth factor delivery applications. This schematic illustrates the two developed hydrogel formulations and the experimental workflow used to evaluate their physico‐chemical properties in vitro ...
Alessia Longoni, Gretel S. Major, Sam Arnold, Samuel Tomkins, Eugenia Spessot, Scott Loeffler, Kieran Lau, Richard Tan, Jessica Harte, Roslyn Kemp, Tess Reynolds, Jelena Rnjak‐Kovacina, Gary J. Hooper, Tim B. F. Woodfield, David C. Kieser, Khoon S. Lim   +15 more
wiley   +1 more source

Organizational problems and possible ways of its resolve when providing emergency surgical care to patients with comorbid status in a highly specialized medical institution

Исследования и практика в медицине, 2020
Purpose of the study. To demonstrate the difficulties of objective interpretation of providing medical care to patients with critical limb ischemia.Materials and methods.
I. M. Khokhlova, V. B. Kozhevnikov, K. N. Movchan, B. S. Artyushin, E. V. Bartashevich, A. V. Zharkov, E. V. Zheleznyi   +6 more
doaj   +1 more source

E-Selectin/AAV2/2 Gene Therapy Alters Angiogenesis and Inflammatory Gene Profiles in Mouse Gangrene Model

Frontiers in Cardiovascular Medicine, 2022
For patients with chronic limb-threatening ischemia and limited revascularization options, alternate means for therapeutic angiogenesis and limb salvage are needed.
Antoine J. Ribieras, Yulexi Y. Ortiz, Yan Li, Carlos T. Huerta, Nga Le, Hongwei Shao, Roberto I. Vazquez-Padron, Roberto I. Vazquez-Padron, Zhao-Jun Liu, Zhao-Jun Liu, Omaida C. Velazquez, Omaida C. Velazquez   +11 more
doaj   +1 more source

Critical Limb Ischemia: Epidemiology [PDF]

Methodist DeBakey Cardiovascular Journal, 2012
Critical limb ischemia is found in 12% of the U.S. adult population. Its clinical presentation varies from no symptoms to intermittent claudication, atypical leg pain, rest pain, ischemic ulcers, or gangrene. Those with critical limb ischemia have a high incidence of cardiovascular comorbidities that reflect a significant systemic atherosclerotic ...
openaire   +2 more sources