Results 61 to 70 of about 38,429 (312)

Cell Therapy in Patients with Critical Limb Ischemia

Stem Cells International, 2015
Critical limb ischemia (CLI) represents the most advanced stage of peripheral arterial obstructive disease (PAOD) with a severe obstruction of the arteries which markedly reduces blood flow to the extremities and has progressed to the point of severe ...
Rita Compagna, Bruno Amato, Salvatore Massa, Maurizio Amato, Raffaele Grande, Lucia Butrico, Stefano de Franciscis, Raffaele Serra   +7 more
doaj   +1 more source

Accuracy of SVS-WIfI Classification in Predicting Major Amputation in Critical Limb Ischemic Patients

Majalah Kedokteran Bandung, 2020
In 2014, The Society for Vascular Surgery revealed a new classification system for Critical Limb Ischemia (CLI) referred as the Society for Vascular Surgery Lower Extremity Threatened Limb Classification System based on Wound, Ischemia, and foot ...
Teguh Marfen Djajakusumah, Rani Septrina, Putie Hapsari, Rendy Susanto   +3 more
doaj   +1 more source

FMO2 Promotes Angiogenesis via Regulation of N‐Acetylornithine

Advanced Science, EarlyView.
This study identifies flavin‐containing monooxygenase 2 (FMO2) as a novel proangiogenic regulator in endothelial cells. Targeted FMO2 ablation impairs vessel sprouting, whereas its compensation potently enhances angiogenesis. Metabolomics and single‐cell sequencing reveal that FMO2 drives vascular growth via the N‐acetylornithine/ATF3/NOTCH1 axis ...
Jingyi Wang, Yinghui Xu, Xianpeng Wu, Mo Li, Changchen Xiao, Zaiyang Fu, Yongjian Chen, Qingju Li, Yating Ruan, Jing Zhao, Zhiwei Zhong, Jinghai Chen, Wei Zhu, Jinliang Nan, Cheng Ni, Xinyang Hu   +15 more
wiley   +1 more source

Critical limb ischemia: an update for interventional radiologists

Diagnostic and Interventional Radiology, 2013
Critical limb ischemia (CLI) is a growing epidemic with bleak patient outcomes. A variety of treatment modalities have been adopted to address CLI based on comorbidities, life expectancy, and the nature of the arterial disease.
Nicholas F. Brazeau,, Erique G. Pinto,, Harlan B. Harvey,, George R. Oliveira,, Benjamin J. Pomerantz,, Stephan Wicky,, Rahmi Oklu   +6 more
doaj   +1 more source

Dnmt1 Alleviates S1PR1‐Mediated Pyroptosis after Spinal Cord Injury through Regulating Pon3 Expression

Advanced Science, EarlyView.
This study systematically explores the action mechanism of Pon3 and its regulatory targets in spinal cord injury (SCI). It demonstrates that Dnmt1 regulates Pon3 expression by modulating methylation levels, thereby inhibiting S1PR1‐mediated pyroptosis and improving SCI prognosis.
Birong Peng, Haolong Lin, Mi Zhang, Wenhao Kuang, Jiaqi Zhang, Shuai Wang, Yuanfang Sun, Wenning Xu, Lixin Zhu   +8 more
wiley   +1 more source

Is amputation in the elderly patient with critical limb ischemia acceptable in the long term?

Clinical Interventions in Aging, 2019
Chloé ML Peters,1 Jolanda de Vries,2,3 Eelco J Veen,1 Hans GW de Groot,1 Gwan H Ho,1 Paul Lodder,2,4 Stijn L Steunenberg,1 Lijckle van der Laan11Department of Surgery, Amphia Hospital, Breda, The Netherlands; 2Department of Medical and ...
Peters CML, de Vries J, Veen EJ, de Groot HGW, Ho GH, Lodder P, Steunenberg SL, van der Laan L   +7 more
doaj  

Myocardial revascularization in diabetic patients presenting with critical limbischemia

Сахарный диабет, 2010
The frequency of diabetic complications remains high despite the development of improved therapeutic modalities. Macroangiopathy continues to bethe predominant complication while coronary heart disease is the main cause of mortality.This paper considers ...
Ivan Ivanovich Dedov, Victor Yur'evich Kalashnikov, Konstantin Vladimirovich Melkozerov   +2 more
doaj   +1 more source

Regenerative Medicine in Critical Limb Ischemia

Journal of Atherosclerosis and Thrombosis, 2012
Critical limb ischemia (CLI) is commonly caused by atherosclerotic arterial obstruction or stenosis in the leg, as demonstrated by rest pain, skin ulcers and gangrene (Fontaine III or IV), often fails to respond to conservative treatments, and carries a high risk for limb amputation, with a particularly dismal prognosis.
Masanori Fukushima, Yoji Nagai, Takayuki Ohno, Hideaki Kaneda   +3 more
openaire   +3 more sources

Loss of Hepatic Angiotensinogen Attenuates Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
Increased hepatic angiotensinogen (AGT) abundance leads to cardiac diastolic dysfunction via the AngII‐independent pathway. Liver‐derived AGT is internalized by LRP2 in cardiac endothelial cells, subsequently contributing to myocardial diastolic dysfunction by suppressing microvascular angiogenesis via inhibiting the GATA2/Pim3 pathway.
Zetao Heng, Min Hong, Zhaocai Zhang, Ximing Ye, Jianan Zhou, Wentao Wu, Jiabing Rong, Yinchuan Xu   +7 more
wiley   +1 more source

Deep venous arterialization in the acute setting for embolic complication after endovascular procedure

Annals of Vascular Surgery - Brief Reports and Innovations
We report a case of a patient that developed acute limb ischemia secondary to atherectomy related embolization that was rescued with a deep venous arterialization (DVA) procedure.
Alejandra P. Rodriguez, Antonio Solano, Sofia K. Babool, Suyue M. Zhang, Lawrence A. Lavery, Michael C. Siah   +5 more
doaj   +1 more source