Results 81 to 90 of about 98,922 (352)

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

A Time‐Programmed Bilayer Wound Dressing for Dynamic Microenvironment Modulation and Full‐Thickness Regeneration in Diabetic Wounds

Advanced Science, EarlyView.
The Polyphenol+PDGF‐BB scaffold fabrication (Panel A) and its dual wound healing effects (Panel B: anti‐inflammation and accelerated tissue remodeling). ABSTRACT Chronic diabetic wounds suffer from dysfunctional repair programs due to accumulated advanced glycation end products (AGEs) and persistent inflammation in hyperglycemic microenvironments ...
Lei Yi, Wanqian Li, Ying Duanmu, Zihan Zhang, Shixuan Chen, Shichu Xiao, Lei Du, Miaomiao Wei   +7 more
wiley   +1 more source

Cell Therapy in Patients with Critical Limb Ischemia

Stem Cells International, 2015
Critical limb ischemia (CLI) represents the most advanced stage of peripheral arterial obstructive disease (PAOD) with a severe obstruction of the arteries which markedly reduces blood flow to the extremities and has progressed to the point of severe ...
Rita Compagna, Bruno Amato, Salvatore Massa, Maurizio Amato, Raffaele Grande, Lucia Butrico, Stefano de Franciscis, Raffaele Serra   +7 more
doaj   +1 more source

Cost-Effective, Safe, and Personalized Cell Therapy for Critical Limb Ischemia in Type 2 Diabetes Mellitus

Frontiers in Immunology, 2019
Cell therapy is a progressively growing field that is rapidly moving from preclinical model development to clinical application. Outcomes obtained from clinical trials reveal the therapeutic potential of stem cell-based therapy to deal with unmet medical
Bárbara Soria-Juan, Natalia Escacena, V. Capilla-González, Y. Aguilera, L. Llanos, J. Tejedo, F. Bedoya, Verónica Juan, Antonio Martínez de la Cuesta, R. Ruiz-Salmerón, E. Andreu, Lukas Grochowicz, F. Prósper, F. Sanchez-Guijo, F. Lozano, Manuel Miralles, Lourdes del Río-Solá, G. Castellanos, J. Moraleda, R. Sackstein, M. García-Arranz, D. García-Olmo, F. Martín, A. Hmadcha, B. Soria   +24 more
semanticscholar   +1 more source

Biodegradable Adhesive Systems for Bio‐Integrated Applications

Advanced Science, EarlyView.
Biodegradable adhesives provide temporary yet reliable adhesion while degrading into safe, non‐toxic by‐products under physiological or environmental conditions. This review summarizes recent developments in physical and chemical adhesion mechanisms—including hydrogen bonding, catechol chemistry, amine‐carboxyl coupling, and emerging diazirine and urea
Won Bae Han, Sungkeun Han, Prashant Shivaji Shewale, Hyewon Cho, Li‐Hyun Kim, Venkata Ramesh Naganaboina, Suk‐Won Hwang   +6 more
wiley   +1 more source

Successful revascularization of the occluded anterior tibial artery using ultrasound-guided puncture of the occluded dorsal pedal artery: A case report with literature review

Radiology Case Reports
A bidirectional approach is necessary for treating critical limb ischemia with complex, multiple lesions. We report an ultrasound-guided bidirectional puncture through an occluded vessel to treat an obstruction extending from the anterior tibial artery ...
Shota Tanaka, Tomonori Nakamura, Rika Yoshida, Takeshi Yoshizako, Yasushi Kaji   +4 more
doaj   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Critical limb ischemia: an update for interventional radiologists

Diagnostic and Interventional Radiology, 2013
Critical limb ischemia (CLI) is a growing epidemic with bleak patient outcomes. A variety of treatment modalities have been adopted to address CLI based on comorbidities, life expectancy, and the nature of the arterial disease.
Nicholas F. Brazeau,, Erique G. Pinto,, Harlan B. Harvey,, George R. Oliveira,, Benjamin J. Pomerantz,, Stephan Wicky,, Rahmi Oklu   +6 more
doaj   +1 more source

Accuracy of SVS-WIfI Classification in Predicting Major Amputation in Critical Limb Ischemic Patients

Majalah Kedokteran Bandung, 2020
In 2014, The Society for Vascular Surgery revealed a new classification system for Critical Limb Ischemia (CLI) referred as the Society for Vascular Surgery Lower Extremity Threatened Limb Classification System based on Wound, Ischemia, and foot ...
Teguh Marfen Djajakusumah, Rani Septrina, Putie Hapsari, Rendy Susanto   +3 more
doaj   +1 more source

A Conjugation Delivery System of Macrophages and Platelet Pharmacytes Promotes Regeneration After Spinal Cord Injury

Advanced Science, EarlyView.
A macrophage–platelet conjugation system (M‐P‐NPs@PPARγ) targets injure tissue to co‐deliver platelet mitochondria and PPARγ‐encoding NPs. This strategy boosts the macrophage energy supply and restores lipid homeostasis, leading to synergistically enhanced efferocytosis and tissue repair Abstract Mitochondrial dysfunction occurs in macrophages with ...
Haoli Wang, Hao Hu, Yijun Li, Lintao Hu, Chenhui Gu, Yiwei Zhu, Jing Huang, Na Li, Shuqi Jiang, Shouyan Zu, Jiachen Xu, Yining Wang, Ke Yang, Pengfei Chen, Liqing Shangguan, Yongcheng Wang, Shunwu Fan, Xianfeng Lin, Qingqing Wang   +18 more
wiley   +1 more source