Results 81 to 90 of about 88,305 (355)

Compound heterozygous loss‐of‐function variants in BRAT1 cause lethal neonatal rigidity and multifocal seizure syndrome

Molecular Genetics &Genomic Medicine, Volume 11, Issue 1, January 2023., 2023
Trio‐based whole‐exome sequencing (WES) and Sanger sequencing identified a novel splicing mutation c.431‐2A>G and a heterozygous truncating mutation c.1359_1361del in BRAT1 in the proband. In addition, our research demonstrated the intronic mutation could lead to aberrant mRNA splicing and further contributed to a better understanding and establishment
Shan Li, Shunan Yu, Yanzhuo Zhang, Ying Wang, Xu Jiang, Chengai Wu   +5 more
wiley   +1 more source

In Vivo Reprogramming of Tissue‐Derived Extracellular Vesicles for Treating Chronic Tissue Injury Through Metabolic Engineering

Advanced Science, EarlyView.
Inspired by exercise‐induced metabolic rewiring and EV secretion, this study shows that in vivo metabolic engineering strategy can reprogram EV secretion pattern and simultaneously attenuate multiple tissue injury in CKD status, highlighting that it is a potential strategy for treating diverse chronic diseases.
Meng Zhao, Shuyun Liu, Yizhuo Wang, Peng Lou, Ke Lv, Tian Wu, Lan Li, Qianyi Wu, Jiaying Zhu, Yanrong Lu, Meihua Wan, Jingping Liu   +11 more
wiley   +1 more source

Actual experience of the training effect of Baduanjin on patients with hemiplegic limb dysfunctions after cerebral infarction: A qualitative study

Nursing Open, Volume 10, Issue 2, Page 861-868, February 2023., 2023
Abstract Aim To explore the actual experience of training effect of Baduanjin on patients with hemiplegic limb dysfunctions after cerebral infarction through semistructured interviews and promote Baduanjin training application in clinical and community settings.
Yan‐tan Liao, Qing‐Xiang Zheng, Ping‐ping Huang, Qiu‐lin Xie, Guan‐dong Wang, Yu‐ting Lai, Xin‐yong Jiang, Li Ge   +7 more
wiley   +1 more source

Electroactive Electrospun Nanofibrous Scaffolds: Innovative Approaches for Improved Skin Wound Healing

Advanced Science, EarlyView.
This review explores the potential of electroactive electrospun nanofibrous (EEN) scaffolds for enhanced skin wound healing. It discusses how a variety of electroactive materials can be prepared into EEN scaffolds via electrospinning technology, and their applications in various wound types. The review provides insights into the future perspectives for
Yang Zhang, Zhiyuan Zheng, Shilu Zhu, Liang Xu, Qingdong Zhang, Jie Gao, Min Ye, Shuwei Shen, Jinyu Xing, Ming Wu, Ronald X. Xu   +10 more
wiley   +1 more source

Cost-Effective, Safe, and Personalized Cell Therapy for Critical Limb Ischemia in Type 2 Diabetes Mellitus

Frontiers in Immunology, 2019
Cell therapy is a progressively growing field that is rapidly moving from preclinical model development to clinical application. Outcomes obtained from clinical trials reveal the therapeutic potential of stem cell-based therapy to deal with unmet medical
Bárbara Soria-Juan, Natalia Escacena, V. Capilla-González, Y. Aguilera, L. Llanos, J. Tejedo, F. Bedoya, Verónica Juan, Antonio Martínez de la Cuesta, R. Ruiz-Salmerón, E. Andreu, Lukas Grochowicz, F. Prósper, F. Sanchez-Guijo, F. Lozano, Manuel Miralles, Lourdes del Río-Solá, Gregorio Castellanos, J. Moraleda, R. Sackstein, M. García-Arranz, D. García-Olmo, F. Martín, A. Hmadcha, B. Soria   +24 more
semanticscholar   +1 more source

Fish Swim Bladder‐Derived ECM Hydrogels Effectively Treat Myocardial Ischemic Injury through Immunomodulation and Angiogenesis

Advanced Science, EarlyView.
A unique hydrogel based on extracellular matrix from fish swim bladder, which is suitable for transcatheter delivery and possesses remarkable reparative capabilities for treating heart failure, is developed. It emerges as a multi‐effect factor profoundly influencing inflammation regulation, angiogenesis, and myocardial metabolism.
Yulong Fu, Canran Gao, Hailing Zhang, Jing Liu, Boxuan Li, Wei Chen, Xiuping Chen, Xue Lin, Ligang Fang, Zhihong Wang   +9 more
wiley   +1 more source

Two effective cases of additional pedal artery angioplasty for severe lower limb ischemia following acute thrombotic artery occlusion with hypercoagulable state diseases

CVIR Endovascular, 2020
Background Acute limb ischemia (ALI) and critical limb ischemia (CLI) following ALI are life-threatening diseases. The rare potential causes of ALI include hypercoagulable state diseases, such as antiphospholipid syndrome (APS) and essential ...
Keisuke Shoji, Kan Zen, Kenji Yanishi, Noriyuki Wakana, Naohiko Nakanishi, Takeshi Nakamura, Satoaki Matoba   +6 more
doaj   +1 more source

Extensive skeletal muscle cell mitochondriopathy distinguishes critical limb ischemia patients from claudicants.

JCI Insight, 2018
The most severe manifestation of peripheral arterial disease (PAD) is critical limb ischemia (CLI). CLI patients suffer high rates of amputation and mortality; accordingly, there remains a clear need both to better understand CLI and to develop more ...
Terence E. Ryan, D. Yamaguchi, Cameron A. Schmidt, Tonya N Zeczycki, S. Shaikh, Patricia M. Brophy, T. D. Green, Michael D. Tarpey, R. Karnekar, Emma J. Goldberg, G. Sparagna, Maria.J. Torres, B. Annex, P. Neufer, E. Spangenburg, J. McClung   +15 more
semanticscholar   +1 more source

Risk Factors and Predictive Model for Ischemic Complications in Endovascular Treatment of Intracranial Aneurysms: Insights From a Large Patient Cohort

AGING MEDICINE, EarlyView.
Independent risk factors for ischemic complications in endovascular treatment of intracranial aneurysms were identified using machine learning methods, and the first prediction model for ischemic complications of all intracranial aneurysms was constructed. Moreover, the model showed a stable and excellent predictive efficacy.
Jianwen Jia, Zeping Jin, Mirzat Turhon, Yixin Lin, Xinjian Yang, Yang Wang, Yunpeng Liu   +6 more
wiley   +1 more source

Endovascular-First Treatment Is Associated With Improved Amputation-Free Survival in Patients With Critical Limb Ischemia.

Circulation. Cardiovascular Quality and Outcomes, 2019
BACKGROUND Critical limb ischemia remains a difficult disease to treat, with limited level one data. The BEST-CLI trial (Best Endovascular vs Best Open Surgical Therapy in Patients with Critical Limb Ischemia) is attempting to answer whether initial ...
Jonathan H. Lin, A. Brunson, P. Romano, M. Mell, Misty D. Humphries   +4 more
semanticscholar   +1 more source