Results 81 to 90 of about 10,215,756 (277)

Roller compaction scale-up using roll width as scale factor and laser-based determined ribbon porosity as critical material attribute

European Journal of Pharmaceutical Sciences, 2016
Due to the complexity and difficulties associated with the mechanistic modeling of roller compaction process for scale-up, an innovative equipment approach is to keep roll diameter fixed between scales and instead vary the roll width. Assuming a fixed gap and roll force, this approach should create similar conditions for the nip regions of the two ...
Morten, Allesø, René, Holm, Per, Holm
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Critical Quality Attributes of Lipid Nanoparticles for mRNA: Selection, Justification, and Control

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. Lipid nanoparticles represent a promising platform for targeted drug delivery, including nucleic acids, as demonstrated by COVID-19 vaccines. Unlike conventional dosage forms, lipid nanoparticles are complex supramolecular systems where the
U. A. Efremova, I. I. Terninko
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Using an eportfolio to enhance graduate attributes among engineering students in Malaysia [PDF]

, 2012
The broad context for this study is that all Malaysian public and private universities must incorporate graduate attributes into their curriculum from August 2006.
Khoo, Linda Mei Sui
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Authorisation using Attributes from Multiple Authorities [PDF]

, 2006
As attribute based authorisation infrastructures such as XACML gain in popularity, linking together user attributes from multiple attribute authorities (AAs) is becoming a pressing problem.
David W Chadwick, Chadwick, David W.
core   +1 more source

Bacteriophage RNA polymerases: catalysts for mRNA vaccines and therapeutics

Frontiers in Molecular Biosciences
Decades of research on bacteriophage-derived RNA polymerases (RNAPs) were vital for synthesizing mRNA using the in vitro transcription (IVT) reaction for vaccines during the COVID-19 pandemic.
Adithya Nair, Zoltán Kis, Zoltán Kis
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Achieving Long‐Term Operational Stability of Perovskite Solar Cells with a Stabilized Efficiency Exceeding 20% after 1000 h

Advanced Science, 2019
Perovskite solar cells (PSCs) with mesoporous TiO2 (mp‐TiO2) as the electron transport material attain power conversion efficiencies (PCEs) above 22%; however, their poor long‐term stability is a critical issue that must be resolved for commercialization.
Tae‐Youl Yang, Nam Joong Jeon, Hee‐Won Shin, Seong Sik Shin, Young Yun Kim, Jangwon Seo   +5 more
doaj   +1 more source