Results 71 to 80 of about 2,672,882 (329)

Struggling for a feasible tool – the process of implementing a clinical pathway in intensive care: a grounded theory study

BMC Health Services Research, 2018
Background Clinical pathways can enhance care quality, promote patient safety and optimize resource utilization. However, they are infrequently utilized in intensive care. This study aimed to explain the implementation process of a clinical pathway based
Petronella Bjurling-Sjöberg, Barbro Wadensten, Ulrika Pöder, Inger Jansson, Lena Nordgren   +4 more
doaj   +1 more source

Critical pathway for stroke

Nosotchu, 2002
The use of critical pathway is becoming increasingly important in acute stroke therapy. Rehabilitation in the recovery stage could be done in the specialized rehabilitation hospitals within Kumamoto according to inter-hospital cooperation. Our acute stroke team can concentrate on the treatment of stroke in the acute stage (within 2-3 week from the ...
Yoichiro Hashimoto, Toshiro Yonehara, Yuichiro Inadomi, Teruyuki Hirano, Makoto Uchino   +4 more
openaire   +2 more sources

The Emerging Role of Ten-Eleven Translocation 1 in Epigenetic Responses to Environmental Exposures. [PDF]

, 2020
Mounting evidence from epidemiological studies and animal models has linked exposures to environmental factors to changes in epigenetic markers, especially in DNA methylation.
Brown, Anthony P, Ji, Hong, Zhu, Tao
core  

Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease [PDF]

, 2011
Chronic obstructive pulmonary disease (COPD) is a global health problem, and current therapy for COPD is poorly effective and the mainstays of pharmacotherapy are bronchodilators.
Adenuga, Adenuga, Adenuga, Adenuga, Algood, Allison, Andersson, Andre, Anest, Arunachalam, Bannister, Barnes, Beeh, Bertolotti, Bessac, Biswal, Blake, Borchers, Borchers, Borchers, Bowie, Bracke, Caito, Caito, Calabrese, Capelli, Carrero, Carrozza, Celedon, Chen, Chen, Chen, Chen, Chen, Cheung, Cho, Christman, Church, Combadiere, Combadiere, Cosio, Costa, Csiszar, Cullinan, Cullinan, Dahl, De Boer, De Boer, de Boer, De Boer, de Ruijter, Decramer, Dekhuijzen, Dentener, Di Stefano, Dinarello, Donnelly, Duran, Edirisinghe, El Moussaoui, Facchinetti, Feghali-Bostwick, Ferrer, Foronjy, Franciosi, Furukawa, Galasinski, Ganguly, Gargalovic, Georgiou, Ghosh, Gongora, Goven, Gracie, Grumelli, Hardaker, Harding, Harju, Harju, Harrison, He, Hengstermann, Hogg, Hogg, Hongwei Yao, Hoshino, Hoshino, Hoshino, Hung, Hwang, Ichinose, Igishi, Iizuka, Imaoka, Imhof, Irfan Rahman, Ishii, Ito, Ito, Ito, Ito, Jorgensen, Juul, Kamei, Kang, Kang, Kasahara, Kassim, Kawahara, Keatings, Keatings, Kelsen, Kim, Kinnula, Kode, Kucukaycan, Lee, Lee, Lee, Leitges, Liu, Lukacs, Luo, Macnee, MacNee, Mahler, Mak, Malhotra, Mattagajasingh, McComb, Meja, Michaud, Michishita, Milne, Milne, Miotto, Mojtahedi, Moretti, Morrison, Motz, Murooka, Nakamaru, Nan, Netea, Niess, Ning, Nisoli, Nozik-Grayck, Ota, Ota, Pantano, Park, Pesci, Petersen, Petrache, Pinamonti, Porter, Potente, Potente, Rabe, Rahman, Rahman, Rahman, Rahman, Rajendrasozhan, Rajendrasozhan, Rangasamy, Rennard, Repine, Ryter, Rytila, Saetta, Saha, Saha, Sandford, Scherz-Shouval, Scherz-Shouval, Senftleben, Sengupta, Sethi, Sethi, Shapiro, Siedlinski, Simon, Singh, Siva, Sizemore, Soler, Sullivan, Sussan, Suzuki, Thatcher, Thomson, Tomaki, Traves, Trevisani, Tsoumakidou, Tuder, Turato, van der Pouw Kraan, van der Strate, van der Vlies, Van Gool, van Overveld, Vaziri, Vermeulen, Vlahos, Wang, Widdowson, Wright, Wright, Xiao, Yagi, Yamamoto, Yamato, Yang, Yang, Yang, Yang, Yang, Yang, Yao, Yao, Yao, Yao, Yin, Young, Zhang, Zhang, Zheng, Zochbauer-Muller   +230 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Targeting inflammatory pathways in axial spondyloarthritis. [PDF]

, 2019
The triggers and pathogenesis of axial spondyloarthritis (axSpA) are not yet completely understood. However, therapeutic agents targeting tumor necrosis factor-α and interleukin-17 inflammatory pathways have proven successful in suppressing many of the ...
Furst, Daniel E, Louie, James S
core  

Inhibition of Ubc13-mediated ubiquitination by GPS2 regulates multiple stages of B cell development [PDF]

, 2016
Non-proteolytic ubiquitin signaling mediated by Lys63 ubiquitin chains plays a critical role in multiple pathways that are key to the development and activation of immune cells.
Aggarwal, Akira, Allman, Amanda Lopacinski, Anna C. Belkina, Baer, Banerji, Barbara S. Nikolajczyk, Bhoj, Bianchi, Bogdan Tanasa, Branigan, Cardamone, Cardamone, Cariappa, Carly T. Cederquist, Cederquist, Chen, Chen, Cheng, Chow, Chu, Chun, Cilloni, Ciriello, Claudia Lentucci, Compagno, Coornaert, Davis, DeFuria, Dengler, Diederichs, Dunne, Fabris, Fan, Flemming, Giltiay, Guo, Habelhah, Haslinger, Hayden, Ho, Holly E. Johnson, Honma, Horikawa, Ikeda, Iwai, Jakobsson, Jennifer Snyder-Cappione, Jiang, Jiang, Jin, Jin, Juang, Jumaa, Karin, Kato, Katz, Kobayashi, Kotecha, Landmann, Langmead, Lee, Lee, Li, Lino, Liu, M. Dafne Cardamone, Malynn, Marchant, Maspero, Michelle Chan, Minegishi, Moran, Nagy, Notley, Ochiai, Oeckinghaus, Ori, Panda, Pappu, Peng, Peng, Pickart, Pillai, Popovic, Pruneda, Pugh, Pulvino, Qiu, Rickert, Ruland, Saito, Sanyal, Sato, Schmidt-Supprian, Shah, Sherry Prasad, Skaug, Spain, Stefano Monti, Stephens, Stringer, Sun, Sun, Szydlowski, Tavares, Toubal, Touma, Valentina Perissi, Venteclef, Wang, Wasserman, Weigert, Wiener, Witt, Wu, Yamamoto, Yang, Yao, Zhang, Zhang, Zhang   +122 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Sestrins are evolutionarily conserved mediators of exercise benefits. [PDF]

, 2020
Exercise is among the most effective interventions for age-associated mobility decline and metabolic dysregulation. Although long-term endurance exercise promotes insulin sensitivity and expands respiratory capacity, genetic components and pathways ...
Brooks, Susan V, Cho, Chun-Seok, Cobb, Tyler, Davis, Carol, Gu, Bondong, Karin, Michael, Kim, Boyoung, Kim, Myungjin, Kowalsky, Allison H, Lee, Jun Hee, Namkoong, Sim, Ro, Seung-Hyun, Semple, Ian, Sujkowski, Alyson, Wessells, Robert J   +14 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source