Results 111 to 120 of about 849,758 (304)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Canadian Library Human Resources Short-Term Supply and Demand Crisis Is Averted, But a Significant Long-Term Crisis Must Be Addressed

Evidence Based Library and Information Practice, 2007
Objective – To examine the human resources environment in Canadian libraries in order to assess readiness to accommodate change and to identify opportunities for human resources planning.
Julie McKenna
doaj   +1 more source

Dynamic Phase Transition, Universality, and Finite-size Scaling in the Two-dimensional Kinetic Ising Model in an Oscillating Field

, 2000
We study the two-dimensional kinetic Ising model below its equilibrium critical temperature, subject to a square-wave oscillating external field. We focus on the multi-droplet regime where the metastable phase decays through nucleation and growth of many
A. Aharoni, A. Cheng, A. N. Kolmogorov, B. Chakrabarti, B. D. Lubachevsky, B. D. Lubachevsky, B. Schmittmann, C. J. White, C. P. Steinmetz, D. P. Landau, E. Warburg, G. Grinstein, G. Kamieniarz, G. Korniss, G. Korniss, G. Korniss, G. M. Buendía, G. M. Buendía, H. L. Richards, H. M. Duiker, H. Tomita, J. A. Ewing, J. A. Ewing, J. F. F. Mendes, J. H. Suen, J. H. Suen, J. Marro, K. Binder, K.-t. Leung, K.-t. Leung, L. Onsager, M. A. Novotny, M. Acharyya, M. Acharyya, M. Acharyya, M. Acharyya, M. Avrami, M. Avrami, M. Avrami, M. E. Fisher, M. F. Zimmer, M. Kolesik, M. Rao, M. Rao, N. Goldenfeld, P. A. Rikvold, P. A. Rikvold, P. A. Rikvold, P. A. Rikvold, P. D. Beale, P. Jung, Q. Jiang, Q. Jiang, R. A. Ramos, S. J. Mitchell, S. W. Sides, S. W. Sides, S. W. Sides, S. W. Sides, T. Tomé, V. N. Smelyanskiy, W. A. Johnson, W. Janke, W. S. Lo, Y. He   +64 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Application of 3D-printed compensators for proton pencil beam scanning of shallowly localized pediatric tumors

Radiation Oncology
Background In modern proton radiotherapy facilities with pencil beam scanning technology, the lowest energy of a proton beam typically ranges between 60 and 100 MeV, corresponding to a proton range in water of 3.1–7.5 cm.
Agnieszka Wochnik, Tomasz Kajdrowicz, Gabriela Foltyńska, Dawid Krzempek, Katarzyna Krzempek, Krzysztof Małecki, Marzena Rydygier, Jan Swakoń, Paweł Olko, Renata Kopeć   +9 more
doaj   +1 more source

Contraception & Reproductive Ethic

Voices in Bioethics, 2016
Though the male condom seems almost ubiquitous in current American society, female contraceptive methods constantly seem to be the subject of controversy.
Sophia Yin
doaj   +1 more source

Paula Rego: printmaker [PDF]

, 2005
‘Paula Rego: Printmaker’ is an extended essay commissioned from the author by Marlborough Fine Art and Talbot Rice Museum, Edinburgh, for the illustrated catalogue to accompany the touring exhibition of Rego’s graphic work.
Coldwell, Paul
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Visual Acuity, Defocus Curve, Reading Speed and Patient Satisfaction with a Combined Extended Depth of Focus Intraocular Lens and Multifocal Intraocular Lens Modality

Clinical Ophthalmology, 2020
Helga P Sandoval,1 Richard Potvin,2 Kerry D Solomon1 1Carolina Eyecare Physicians, LLC, Mt. Pleasant, SC, USA; 2Science in Vision, Bend, OR, USACorrespondence: Kerry D SolomonCarolina Eyecare Physicians, LLC, 1101 Clarity Road, Suite 100, Mt Pleasant, SC
Sandoval HP, Potvin R, Solomon KD
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