CNS Neuroscience &Therapeutics, Volume 30, Issue 8, August 2024.Lacosamide (LCM) is effective, safe, and well‐tolerated as an adjunctive therapy in young Chinese children aged ≥1 month to ≤4 years. The order of lacosamide introduction significantly influenced its short‐term efficacy. Abstract Aims To evaluate the efficacy, safety, and tolerability of adjunctive lacosamide therapy against focal seizures in young ...
Lu Yang +6 more
wiley +1 more source
Poly-arginine peptides reduce infarct volume in a permanent middle cerebral artery rat stroke model [PDF]
, 2016 Background: We recently reported that poly-arginine peptides have neuroprotective properties both in vitro and in vivo. In cultured cortical neurons exposed to glutamic acid excitotoxicity, we demonstrated that neuroprotective potency increases with ...
Anderton, R +5 more
core +2 more sources
GSK3: A potential target and pending issues for treatment of Alzheimer's disease
CNS Neuroscience &Therapeutics, Volume 30, Issue 7, July 2024.GSK3 signaling in Alzheimer's disease and targeted therapies. Abstract Glycogen synthase kinase‐3 (GSK3), consisting of GSK3α and GSK3β subtypes, is a complex protein kinase that regulates numerous substrates. Research has observed increased GSK3 expression in the brains of Alzheimer's disease (AD) patients and models.
Jiahui Zhao +6 more
wiley +1 more source
Mitochondria and neuroprotection in stroke: Cationic arginine-rich peptides (CARPs) as a novel class of mitochondria-targeted neuroprotective therapeutics [PDF]
, 2018 Stroke is the second leading cause of death globally and represents a major cause of devastating long-term disability. Despite sustained efforts to develop clinically effective neuroprotective therapies, presently there is no clinically available ...
Anderton, Ryan S +4 more
core +1 more source
Lithium alters expression of RNAs in a type-specific manner in differentiated human neuroblastoma neuronal cultures, including specific genes involved in Alzheimer's disease. [PDF]
, 2019 Lithium (Li) is a medication long-used to treat bipolar disorder. It is currently under investigation for multiple nervous system disorders, including Alzheimer's disease (AD).
Balaraman, Yokesh +7 more
core +3 more sources
Epilepsia, Volume 65, Issue 6, Page 1756-1767, June 2024.Abstract Objective Focal to bilateral tonic–clonic seizures (FBTCS) represent a challenging subtype of focal temporal lobe epilepsy (TLE) in terms of both severity and treatment response. Most studies have focused on regional brain analysis that is agnostic to the distribution of white matter (WM) pathways associated with a node.
Sam S. Javidi +6 more
wiley +1 more source
Центральные и гормональные механизмы адаптации к десинхронизационному стрессу
Интегративная физиологияНа крысах-самцах линии Wistar создана модель 14-суточной десинхронизации циркадианного ритма. В первой серии исследований изучалось влияние десинхронизации на уровень белка 2, опосредующего активность коллапсина (collapsin-response mediator protein 2 ...
Парвин Асад кызы Зульфугарова +1 more
doaj +5 more sources
Efficacy of (S)-lacosamide in preclinical models of cephalic pain
PAIN Reports, 2016 . Migraine is one of the world's most common neurological disorders. Current acute migraine treatments have suboptimal efficacy, and new therapeutic options are needed.
Aubin Moutal +7 more
doaj +1 more source
A high-fat diet induces rapid changes in the mouse hypothalamic proteome [PDF]
, 2019 Funding LMW, FMC, CG, ACM and C-DM were funded by the Scottish Government’s Rural and Environment Science and Analytical Services Division (RESAS). FHM was supported by an EASTBIO DTP BBSRC studentship. DS was supported by a SULSA studentship.
Campbell, Fiona M. +8 more
core +3 more sources
Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulation [PDF]
, 2015 Increasing evidence suggests that recurrent Herpes Simplex Virus type 1 (HSV-1) infection spreading to the CNS is a risk factor for Alzheimer's Disease (AD) but the underlying mechanisms have not been fully elucidated yet.
De Chiara, Giovanna +7 more
core +2 more sources