Chinese Medical Journal, 2015 Background: Collapsin response mediator protein-2 (CRMP2), a multifunctional cytosolic protein highly expressed in the brain, is degraded by calpain following traumatic brain injury (TBI), possibly inhibiting posttraumatic neurite regeneration.
Yun Yu +3 more
doaj +1 more source
Brain‐X, Volume 2, Issue 3, September 2024.An update for molecular basis and treatment: The major posttranslational modification (PTM) changes and crosstalk in the evolution of retinal degenerative disorders including glaucoma, diabetic retinopathy (DR), age‐related macular degeneration and myopia retinopathy.
Ke Yao +3 more
wiley +1 more source
Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration. [PDF]
, 2016 Mechanistic studies of axon growth during development are beneficial to the search for neuron-intrinsic regulators of axon regeneration. Here, we discovered that, in the developing neuron from rat, Akt signaling regulates axon growth and growth cone ...
Ahn, Jee-Yin +9 more
core +2 more sources
Hippocampus, Volume 34, Issue 9, Page 491-502, September 2024.Abstract Hippocampal area CA2 has garnered attention in recent times owing to its significant involvement in social memory and distinctive plasticity characteristics. Research has revealed that the CA2 region demonstrates a remarkable resistance to plasticity, particularly in the Schaffer Collateral (SC)‐CA2 pathway.
Maria Vazquez Pavon +2 more
wiley +1 more source
Mitochondria and neuroprotection in stroke: Cationic arginine-rich peptides (CARPs) as a novel class of mitochondria-targeted neuroprotective therapeutics [PDF]
, 2018 Stroke is the second leading cause of death globally and represents a major cause of devastating long-term disability. Despite sustained efforts to develop clinically effective neuroprotective therapies, presently there is no clinically available ...
Anderton, Ryan S +4 more
core +1 more source
Lithium alters expression of RNAs in a type-specific manner in differentiated human neuroblastoma neuronal cultures, including specific genes involved in Alzheimer's disease. [PDF]
, 2019 Lithium (Li) is a medication long-used to treat bipolar disorder. It is currently under investigation for multiple nervous system disorders, including Alzheimer's disease (AD).
Balaraman, Yokesh +7 more
core +3 more sources
Центральные и гормональные механизмы адаптации к десинхронизационному стрессу
Интегративная физиологияНа крысах-самцах линии Wistar создана модель 14-суточной десинхронизации циркадианного ритма. В первой серии исследований изучалось влияние десинхронизации на уровень белка 2, опосредующего активность коллапсина (collapsin-response mediator protein 2 ...
Парвин Асад кызы Зульфугарова +1 more
doaj +5 more sources
Efficacy of (S)-lacosamide in preclinical models of cephalic pain
PAIN Reports, 2016 . Migraine is one of the world's most common neurological disorders. Current acute migraine treatments have suboptimal efficacy, and new therapeutic options are needed.
Aubin Moutal +7 more
doaj +1 more source
Functions of GSK-3 Signaling in Development of the Nervous System [PDF]
, 2011 Glycogen synthase kinase-3 (GSK-3) is central to multiple intracellular pathways including those activated by Wnt/β-catenin, Sonic Hedgehog, Notch, growth factor/RTK, and G protein-coupled receptor signals.
Woo-Yang Kim, William D. Snider
core +3 more sources
A high-fat diet induces rapid changes in the mouse hypothalamic proteome [PDF]
, 2019 Funding LMW, FMC, CG, ACM and C-DM were funded by the Scottish Government’s Rural and Environment Science and Analytical Services Division (RESAS). FHM was supported by an EASTBIO DTP BBSRC studentship. DS was supported by a SULSA studentship.
Campbell, Fiona M. +8 more
core +3 more sources