Results 121 to 130 of about 3,047 (190)
Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulation [PDF]
, 2015 Increasing evidence suggests that recurrent Herpes Simplex Virus type 1 (HSV-1) infection spreading to the CNS is a risk factor for Alzheimer's Disease (AD) but the underlying mechanisms have not been fully elucidated yet.
De Chiara, Giovanna +7 more
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Neural Plasticity, 2018 Axons are directed to their correct targets by guidance cues during neurodevelopment. Many axon guidance cues have been discovered; however, much less known is about how the growth cones transduce the extracellular guidance cues to intracellular ...
Zhi-Zhi Liu +6 more
doaj +1 more source
Control of neuronal ion channel function by glycogen synthase kinase-3: new prospective for an old kinase [PDF]
, 2012 Glycogen synthase kinase 3 (GSK-3) is an evolutionarily conserved multifaceted ubiquitous enzyme. In the central nervous system (CNS), GSK-3 acts through an intricate network of intracellular signaling pathways culminating in a highly divergent cascade ...
Fernanda Laezza, Norelle C. Wildburger
core +1 more source
Can Maternal Autoantibodies Play an Etiological Role in ASD Development?
Neuropsychiatric Disease and Treatment, 2020 Iva Dudova,1 Klara Horackova,2 Michal Hrdlicka,1 Martin Balastik3 1Department of Child Psychiatry, Charles University Second Faculty of Medicine, Prague, Czech Republic; 2Department of Psychiatry, Charles University First Faculty of Medicine, Prague ...
Dudova I +3 more
doaj
Neural Plasticity, 2016 Proper density and morphology of dendritic spines are important for higher brain functions such as learning and memory. However, our knowledge about molecular mechanisms that regulate the development and maintenance of dendritic spines is limited.
Xiaohua Jin +7 more
doaj +1 more source
Molecular Brain, 2019 Clinical and preclinical studies have shown that patients with Diabetic Neuropathy Pain (DNP) present with increased tumor necrosis factor alpha (TNF-α) serum concentration, whereas studies with diabetic animals have shown that TNF-α induces an increase ...
Flávio Henrique Pequeno de Macedo +13 more
doaj +1 more source
CRMP2 and its phosphorylation prevent axonal misrouting of the corticospinal tract
Neuroscience LettersDuring the development of the central nervous system (CNS), the formation of neural circuits such as the corticospinal tract (CST) is crucial to control voluntary movement and is regulated by axonal guidance mechanisms. In this study, we examined the role of CRMP2 (Collapsin response mediator protein 2) in the formation of CST.
Satohiro Takizawa +6 more
openaire +2 more sources
Evaluation of behavior in transgenic mouse models to understand human congenital pain conditions [PDF]
, 2018 BACKGROUND: Containing a brain for signal processing and decision making, and a peripheral component for sensation and response, the nervous system provides higher organisms a powerful method of interacting with their environment.
Bullock, Daniel
core
GSK3/CRMP2 signaling confers PTEN knockout mediated axonal regeneration
Acta Ophthalmologica, 2019 AbstractKnockout of phosphatase and tensin homolog (PTEN‐/‐) is neuroprotective and promotes axon regeneration in mature neurons. Elevation and maintenance of mTOR activity in injured neurons have been proposed as the main underlying mechanism. Here we demonstrate that PTEN‐/‐ also abrogates the inhibitory activity of GSK3 on collapsin response ...
openaire +1 more source
Интегративная физиологияThe reported study investigates the impact of chronic stress on long-term memory formation and the expression of collapsin-response mediator protein 2 (CRMP2) within various brain structures in Wistar female rats.
Медина Илгар гызы Гасанова +1 more
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