Results 171 to 180 of about 3,056 (192)

Aβ25-35-induced autophagy and apoptosis are prevented by the CRMP2-derived peptide ST2-104 (R9-CBD3) via a CaMKKβ/AMPK/mTOR signaling hub. [PDF]

PLoS One
Ji Y, Ren J, Qian Y, Li J, Liu H, Yao Y, Sun J, Khanna R, Sun L.   +8 more
europepmc   +1 more source

The Roles of the Membrane-Anchored Glycoprotein RECK in Animal Development, Tumor Suppression, and Beyond. [PDF]

Life (Basel)
Noda M, Alexander D, Matsuzaki T.
europepmc   +1 more source

Spine plasticity to restore the cortical networks of movement: a therapeutic approach to spinal cord injury. [PDF]

Brain Commun
Machado C, Hollis E.
europepmc   +1 more source

Quercetin attenuated ischemic stroke induced neurodegeneration by modulating glutamatergic and synaptic signaling pathways.

Heliyon
Shah FA, Albaqami F, Alattar A, Alshaman R, Zaitone SA, Gabr AM, Abdel-Moneim AH, Dosoky ME, Koh PO.   +8 more
europepmc   +1 more source

Leveraging targeted kinase degradation as a novel therapeutic strategy for Alzheimer's disease. [PDF]

RSC Med Chem
Tassinari E, Milelli A.
europepmc   +1 more source

ROCK2 Downregulation in Pediatric Medulloblastoma Increases Migration and Predicts the Involvement of SHH Non-canonical Signaling. [PDF]

Yale J Biol Med
Hakime RG, Nagano LFP, Brassesco MS.
europepmc   +1 more source

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Coordinating Synaptic Signaling with CRMP2

The International Journal of Biochemistry & Cell Biology, 2020
Synaptic transmission is a complex process, dysregulation of which underlies several neurological conditions. Collapsin response mediator protein 2 (CRMP2) is a microtubule associated protein expressed ubiquitously in the central nervous system. Identified initially in the context of Semaphorin 3A (Collapsin) induced growth cone collapse, more recent ...
Harrison Stratton, Lisa Boinon, Aubin Moutal, Rajesh Khanna   +3 more
openaire   +2 more sources

Druggability of CRMP2 for Neurodegenerative Diseases

ACS Chemical Neuroscience, 2020
Collapsin response mediator proteins (CRMPs) are ubiquitously expressed phosphoproteins that coordinate cytoskeletal formation and regulate cellular division, migration, polarity, and synaptic connection. CRMP2, the most studied of the five family members, is best known for its affinity for tubulin heterodimers and function in regulating the ...
Rajesh Khanna, Aubin Moutal, Samantha Perez-Miller, Aude Chefdeville, Lisa Boinon, Marcel Patek   +5 more
openaire   +2 more sources

CRMP2

The Neuroscientist, 2014
Cytoskeletal restructuring is essential for nearly all cellular processes in the developing brain. After cell fate determination, newborn cortical neurons must migrate to their final positions while establishing proper axon-dendrite polarity. Significant progress has recently been made towards understanding the cellular and molecular mechanisms ...
Ip, Jacque P.K., Fu, Amy Kit Yu, Ip, Nancy Yuk Yu   +2 more
openaire   +3 more sources