Results 171 to 180 of about 3,047 (190)

Dehydroamino acids and their crosslinks in Alzheimer's disease aggregates. [PDF]

Brain Commun
Markovich SW, Frey BL, Scalf M, Shortreed MR, Smith LM.   +4 more
europepmc   +1 more source

Intranasal CRMP2-Ubc9 inhibitor regulates Na V 1.7 to alleviate trigeminal neuropathic pain. [PDF]

Pain
Loya-Lopez SI, Allen HN, Duran P, Calderon-Rivera A, Gomez K, Kumar U, Shields R, Zeng R, Dwivedi A, Saurabh S, Korczeniewska OA, Khanna R.   +11 more
europepmc   +1 more source

Reversible downregulation of MYC in a spheroid model of metastatic epithelial ovarian cancer. [PDF]

Cancer Gene Ther
Buensuceso A, Borrelli MJ, Ramos Valdés Y, Shepherd TG.   +3 more
europepmc   +1 more source

Quercetin attenuated ischemic stroke induced neurodegeneration by modulating glutamatergic and synaptic signaling pathways.

Heliyon
Shah FA, Albaqami F, Alattar A, Alshaman R, Zaitone SA, Gabr AM, Abdel-Moneim AH, Dosoky ME, Koh PO.   +8 more
europepmc   +1 more source

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Coordinating Synaptic Signaling with CRMP2

The International Journal of Biochemistry & Cell Biology, 2020
Synaptic transmission is a complex process, dysregulation of which underlies several neurological conditions. Collapsin response mediator protein 2 (CRMP2) is a microtubule associated protein expressed ubiquitously in the central nervous system. Identified initially in the context of Semaphorin 3A (Collapsin) induced growth cone collapse, more recent ...
Harrison Stratton, Lisa Boinon, Aubin Moutal, Rajesh Khanna   +3 more
openaire   +2 more sources

Druggability of CRMP2 for Neurodegenerative Diseases

ACS Chemical Neuroscience, 2020
Collapsin response mediator proteins (CRMPs) are ubiquitously expressed phosphoproteins that coordinate cytoskeletal formation and regulate cellular division, migration, polarity, and synaptic connection. CRMP2, the most studied of the five family members, is best known for its affinity for tubulin heterodimers and function in regulating the ...
Rajesh Khanna, Aubin Moutal, Samantha Perez-Miller, Aude Chefdeville, Lisa Boinon, Marcel Patek   +5 more
openaire   +2 more sources

CRMP2

The Neuroscientist, 2014
Cytoskeletal restructuring is essential for nearly all cellular processes in the developing brain. After cell fate determination, newborn cortical neurons must migrate to their final positions while establishing proper axon-dendrite polarity. Significant progress has recently been made towards understanding the cellular and molecular mechanisms ...
Ip, Jacque P.K., Fu, Amy Kit Yu, Ip, Nancy Yuk Yu   +2 more
openaire   +3 more sources

Modulation of proteoglycan receptor regulates RhoA/CRMP2 pathways and promotes axonal myelination

Neuroscience Letters, 2021
The function of the myelinating system is important because a defective myelin sheath results in various nervous disorders, including multiple sclerosis and peripheral neuropathies. The dorsal root entry zone (DREZ) is a transitional area between the central nervous system (CNS) and the peripheral nervous system (PNS) that is generated by two types of ...
Min, Yao, Jie, Fang, Wei, Tao, Gang, Feng, Mingyi, Wei, Yuhao, Gao, Wen, Xin, Yu, Li, Shiwei, Du   +8 more
openaire   +2 more sources

Ketamine Regulates Phosphorylation of CRMP2 To Mediate Dendritic Spine Plasticity

Journal of Molecular Neuroscience, 2019
Ketamine is widely used in infants and young children for anesthesia, and subanesthetic doses of ketamine make neurons form new protrusions and promote synapse formation. However, the precise pathological mechanisms remain to be elucidated. In this study, we demonstrated that ketamine administration significantly increased dendritic spine density and ...
Zhongqi Zhang, JiFeng Zhang, Jiong Li, Jiaqi Zhang, Li Chen, Yalan Li, Guoqing Guo   +6 more
openaire   +2 more sources