Results 21 to 30 of about 3,702 (135)

Orally Administered Crocin Protects Against Cerebral Ischemia/Reperfusion Injury Through the Metabolic Transformation of Crocetin by Gut Microbiota

Frontiers in Pharmacology, 2019
Our pilot study suggested that orally administered crocin was hardly absorbed into circulatory system, but it was effective against cerebral ischemic/reperfusion (I/R) injury.
Yue Zhang, Jianliang Geng, Yu Hong, Li Jiao, Shuning Li, Runbin Sun, Yuan Xie, Caixia Yan, Jiye Aa, Guangji Wang   +9 more
doaj   +1 more source

Indirect Electrochemical Analysis of Crocin in Phytochemical Sample

E-Journal of Chemistry, 2012
A new electroanalytical method has been developed for the quantitative determination of crocin in a sample of stigmas of saffron (Crocus sativus L.). Crocin is polarographically inactive.
Riyaz Ahmad Dar, Pradeep Kumar Brahaman, Sweety Tiwari, Krishna Sadashiv Pitre   +3 more
doaj   +1 more source

Effects of crocin on spatial or aversive learning and memory impairments induced by lipopolysaccharide in rats [PDF]

Avicenna Journal of Phytomedicine, 2021
Objective: Neuroinflammation and oxidative stress play essential roles in the pathogenesis and progression of neurodegenerative diseases, such as Alzheimer’s disease. Crocin, main active constituent of Crocus sativus L.
Mohammad Javad Azmand, Ziba Rajaei
doaj   +1 more source

Is Crocin a Potential Anti-tumor Candidate Targeting Microtubules? Computational Insights From Molecular Docking and Dynamics Simulations

Frontiers in Molecular Biosciences, 2020
Although it is known crocin, a hydrophilic compound from the herbal plant Crocus sativus L., has promising antitumor activity, the detailed mechanism of its antitumor activity was not well understood.
Ze Wang, Juan Ren, Nengzhi Jin, Xingyi Liu, Xiaofei Li   +4 more
doaj   +1 more source

A preliminary study of the anti-inflammatory and anti-apoptotic effects of crocin against gastric ischemia-reperfusion injury in rats

Brazilian Journal of Pharmaceutical Sciences, 2015
The aim of the present study was to investigate the protective effect of crocin on gastric mucosal lesions caused by ischemia-reperfusion (I/R) injury in rats.
Seyyed Ali Mard, Zahra Nikraftar, Yaghoob Farbood, Esrafil Mansouri   +3 more
doaj   +1 more source

Cardioprotective Effect of Crocin Combined with Voluntary Exercise in Rat: Role of Mir-126 and Mir-210 in Heart Angiogenesis

Arquivos Brasileiros de Cardiologia
Background: Crocin is reported to have a wide range of biological activities such as cardiovascular protection. Recent epidemiologic studies have shown that exercise reduces cardiovascular morbidity and mortality in the general population.
Vajihe Ghorbanzadeh, Mustafa Mohammadi, Hassan Dariushnejad, Alireza Abhari, Leila Chodari, Gisou Mohaddes   +5 more
doaj   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Protective role of crocin against sepsis-induced injury in the liver, kidney and lungs via inhibition of p38 MAPK/NF-κB and Bax/Bcl-2 signalling pathways

Pharmaceutical Biology, 2022
Context Crocin has been reported to have multiple bioactivities. However, the effect of crocin administration on caecal ligation and puncture (CLP)-induced sepsis remains unknown.Objective We investigated the effects of crocin on CLP-induced sepsis in ...
Jun Gao, Feng Zhao, Shaona Yi, Shuhang Li, Aiqing Zhu, Yingxiu Tang, Aiqun Li   +6 more
doaj   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Crocin Inhibits Angiogenesis and Metastasis in Colon Cancer via TNF-α/NF-kB/VEGF Pathways

Cells, 2022
Angiogenesis and metastasis play pivotal roles in the progression of cancer. We recently discovered that crocin, a dietary carotenoid derived from the Himalayan crocus, inhibited the growth of colon cancer cells.
Hamid A. Bakshi, Gerry A. Quinn, Mohamed M. Nasef, Vijay Mishra, Alaa A. A. Aljabali, Mohamed El-Tanani, Ángel Serrano-Aroca, Mateus Webba Da Silva, Paul A. McCarron, Murtaza M. Tambuwala   +9 more
doaj   +1 more source