Results 41 to 50 of about 5,332 (163)

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Crocin treatment improves testosterone induced benign prostatic hyperplasia in rats

, 2022
Background and objective: Benign prostatic hyperplasia (BPH) is a typical nonmalignant growth of the prostate in the elderly. Crocin, a bioactive component of Crocus sativus L., commonly known as saffron, is known to have an anti-proliferative ...
Diaa Fayyad, Alaa A. A. Aljabali, Sahar Omari, Khalid Al-Batanyeh, Bahaa Al-Trad, Mazhar Salim Al Zoubi, Gregory J. Eaton, Janti Qar   +7 more
core   +1 more source

Cardioprotective Effect of Crocin Combined with Voluntary Exercise in Rat: Role of Mir-126 and Mir-210 in Heart Angiogenesis

Arquivos Brasileiros de Cardiologia
Background: Crocin is reported to have a wide range of biological activities such as cardiovascular protection. Recent epidemiologic studies have shown that exercise reduces cardiovascular morbidity and mortality in the general population.
Vajihe Ghorbanzadeh, Mustafa Mohammadi, Hassan Dariushnejad, Alireza Abhari, Leila Chodari, Gisou Mohaddes   +5 more
doaj   +1 more source

From nature to nanoscale: advances, challenges, and preclinical translation of nanofiber drug delivery systems containing plant‐derived active ingredients

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Since the early 1960s, nanotechnology has been a critical area of science, allowing for the development of sophisticated nanomaterials. Nanofibers, one of the most widely used nanotechnological drug delivery systems, have emerged as a highly versatile platform within modern pharmaceutical sciences.
Heybet Kerem Polat, Yasin Turanlı, Nihat Kurt, Sefa Gözcü, Emre Tunçel, Hilal Bacanak, Eren Aytekin, Sedat Ünal   +7 more
wiley   +1 more source

Antioxidant Effect of Continuous Training with Crocin Consumption on Doxorubicin-Induced Hepatotoxicity in Rats [PDF]

Journal of Fasting and Health, 2020
Introduction: It has been reported that doxorubicin can cause liver damage; however, exercise and crocin consumption can improve antioxidant defense.The aim of the present study was to investigate the antioxidant effect of continuous training with crocin
Babak Hamidian, Masoud Nikbakht, Hadi Fathi Moghaddam, Shirin Zilaei Bouri   +3 more
doaj   +1 more source

Use of predictive tools for the analysis of bioactive compounds in Crocus sativus L. flowers

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Crocus sativus L. (saffron) flowers have high bioactive potential because of their content of crocins, safranal and phenolic compounds. The development of predictive models based on near‐infrared (NIR) spectroscopy and partial least squares regression to estimate the antioxidant capacity of saffron flower, evaluated using oxygen ...
Manuel Piqueras‐García, Jorge F Escobar‐Talavera, María Esther Martínez‐Navarro, Gonzalo L Alonso, Rosario Sánchez‐Gómez   +4 more
wiley   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Transdermal delivery of crocin using bacterial nanocellulose membrane

, 2019
This work reports the inclusion of crocin (an active agent of saffron) into bacterial nanocellulose (BNC) membrane for transdermal drug delivery. The BNC showed good uptake of the crocin based on the swelling studies and vibrational peaks of the FTIR ...
Ahmad Zawawi, Nurliyana, Abdul Kadir, Mohammed Rafiq, Mohd. Yusof, Abdul Halim, Abba, Mustapha, Ibrahim, Zaharah, Chong, Chun Shiong, Abd. Razak, Saiful Izwan   +6 more
core   +1 more source

Effects of crocin on experimental obesity and type-2 diabetes [PDF]

, 2016
Background/aim: The aim of this study is to scrutinize the effects of crocin on obesity and type-2 diabetes, with an approach that takes oxidative stress and inflammatory parameters into account.
Hazman, Omer, Buyukben, Ahmet, Aksoy, Lacine   +2 more
core   +1 more source

Effects of Nrf-2/HO-1, NF-κB/Cox-2/TLR-4, and Bax/Bcl-2/caspase-3 pathways in alleviating azithromycin-induced cardiotoxicity in rats: Potential cardioprotective role of crocin [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): This study aimed to investigate the potential protective effects of crocin against azithromycin (AZ)-induced cardiotoxicity.Materials and Methods: The experimental design consisted of four groups: Control, crocin, Azithromycin, and crocin ...
Tuba Dogan, Betul Apaydin Yildirim, Kubra Asena Terim Kapakin, Metin Kiliclioglu, Omercan Alat   +4 more
doaj   +1 more source