Results 41 to 50 of about 3,702 (135)

Evaluating the effect of crocin on contrast-induced nephropathy in rats [PDF]

Avicenna Journal of Phytomedicine
Objective: Contrast-induced nephropathy (CIN) raises the risk of renal injury, but crocin, a saffron component, may improve kidney function. This study investigated crocin's protective effects against CIN in rats.Materials and Methods: Male Wistar rats ...
Mahnaz Zolfaghari Farajerdi, Fatemeh Rajabian, Bibi Marjan Razavi, Mahboobeh Ghasemzadeh Rahbardar, Abolfazl Khajavi Rad, Sakineh Amoueian, Hossein Hosseinzadeh   +6 more
doaj   +1 more source

Virtual Screening of Traditional Chinese Medicine Natural Product Inhibitors Targeting AQP1 for Bladder Cancer

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Bladder cancer (BCa) is the most common and representative type of adult urinary tract urothelial cancer, characterized by high incidence and mortality rates. It has become a major disease threatening public health, highlighting the urgent need for the development of comprehensive treatment strategies, including traditional Chinese ...
Di Liu, Qing‐Yu Zhang
wiley   +1 more source

Anti-apoptotic Effects of Interval and Continued Training and Crocin on the Muscle Tissue of the Rats with Type II Diabetes Induced by a High-fat Diet [PDF]

Journal of Fasting and Health, 2019
Introduction: Diabetes is a metabolic disease, which is directly correlated with increased physical disabilities and muscle tissue damage. The present study aimed to investigate the anti-apoptotic effects of interval and continued training and crocin on ...
Ali Moradi, Seyed Ali Hosseini, Masoud Nikbakht   +2 more
doaj   +1 more source

Multi‐Target Mechanisms of Moroccan Aphrodisiac Plants: An Integrative Computational and Phytochemical Investigation

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Moroccan medicinal plants with in silico‐approved aphrodisiac effects provide 94 phytochemicals. Docking against PDE5, AR, ERα, and aromatase gives top scores for lutein (−10.6), baicalein (−9.5), liquiritigenin (−9.2), and procyanidins (−9.7). ADMET filtering passes baicalein and liquiritigenin but excludes lutein and procyanidins. MD simulations (200 
Amal Elrherabi, Oussama Khibech, Mohamed Bouhrim, Abdelouahid Laftouhi, Abdelaaty A. Shahat, Abdullah R. Alanzi, Rashed N. Herqash, Joe Miantezila Basilua, Mohamed Bnouham   +8 more
wiley   +1 more source

Adverse Events of Saffron (Crocus sativus L.): Systematic Review of Current Evidence

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Crocus sativus L., commonly known as saffron, is a widely used spice with a rich history of culinary and medicinal applications. This systematic review aims to compile human data from studies on monopreparations of C. sativus, including stigma powder and other extracts, to evaluate their safety.
Fatemeh Sadat Hasheminasab, Mahdie Hajimonfarednejad, Seyede Maryam Najibi, Mohammad Hashem Hashempur   +3 more
wiley   +1 more source

Crocin exerts anti-inflammatory and anti-arthritic effects on type II collagen-induced arthritis in rats

Pharmaceutical Biology, 2018
Context: Rheumatoid arthritis (RA) is a common systemic auto-immune disease, which is characterized by chronic and symmetry synovial inflammation. Crocin has been reported to exhibit anti-inflammatory effects in animal models.
Wei Liu, Yufeng Sun, Zhenping Cheng, Yong Guo, Peiming Liu, Ying Wen   +5 more
doaj   +1 more source

Harnessing Free Radical Scavenging Potential of Caffeic Acid as a Nutraceutical—A Review

Food Safety and Health, Volume 4, Issue 2, Page 327-342, April 2026.
Caffeic acid has emerged as a promising bioactive molecule with multiple pharmacological properties, including antioxidant, antimicrobial, anti‐inflammatory, organ protective properties and metal‐chelating ability. This review emphasizes the dietary sources, structural characteristic, molecular mechanism underlying health promoting effects of caffeic ...
Pavitra Behra, Monika Bhadauria, Satendra Kumar Nirala   +2 more
wiley   +1 more source

Saffron Alters Microbial Amino Acid Metabolism and Neurotransmitter Production in a Defined Gut Consortium

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Graphical representation of the metabolic pathways modulated by saffron within defined microbial communities. In the tryptophan pathway, saffron decreased levels of tryptophan and anthranilic acid while increasing concentrations of indole‐3‐acetic acid and tryptamine.
Adelaide E. Horvath, Makenna Grozis, Paul R. S. Baker, Santosh Kapil Kumar Gorti, Robert Proos, Ahmad Imran, Hassan Brim, Thomas D. Horvath, Melinda A. Engevik, Hassan Ashktorab   +9 more
wiley   +1 more source

Protective role of Crocin against nicotine-induced damages on male mice liver

International Journal of Preventive Medicine, 2015
Background: Nicotine is a major pharmacologically active substance in cigarette smoke. It is mainly metabolized in liver and causes devastating effects. Crocin is the chemical ingredient primarily responsible for the color of saffron.
Cyrus Jalili, Hadis Tabatabaei, Seyran Kakaberiei, Shiva Roshankhah, Mohammad Reza Salahshoor   +4 more
doaj   +1 more source

Crocin Supplementation Mitigates DSS‐Induced Ulcerative Colitis by Promoting Autophagy and Modulating Gut Microbiota in Mice

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Crocin enhanced intestinal barrier integrity and alleviated colonic inflammation in DSS‐induced UC mice. Crocin promoted autophagy by targeting the AMPK/mTOR pathway. Crocin reshaped gut microbiota composition of UC mice. ABSTRACT Crocin has been widely recognized for its anti‐inflammatory and antioxidant properties.
Jiaoyang Xu, Xiaoyu Han, Zizheng Nie, Qinglong Cao, Mu Zhang, Yingying Liu, Chenyang Wu, Jun Yang, Shufen Han   +8 more
wiley   +1 more source