Results 51 to 60 of about 5,332 (163)

Plant‐Derived Natural Product Nanodelivery System in Cancer Therapy

Phytotherapy Research, EarlyView.
This review comprehensively summarizes the recent progress and emerging concepts in nanotechnology‐based delivery systems for plant‐derived natural products, with a particular focus on their application in precision cancer therapy. ABSTRACT Plant‐derived natural products have emerged as important sources of anticancer agents because of their diverse ...
Changqi Shi, LuLu Zhang, Lan Yan, Qi Geng, Li Li, Xiaojuan He, Ning Zhao, Yong Tan, Xiaomeng Zhang, Cheng Lu   +9 more
wiley   +1 more source

Extraction optimization crocin pigments of saffron (Crocus sativus) using response surface methodology and determination stability of crocin microcapsules

, 2019
This study aimed to determine optimal extraction parameters by using response surface methodology, examining the effect of microencapsulation on crocin retention, and evaluating the temperature and pH stability of crocin microcapsules.
Karasu, S., SAĞDIÇ, Osman, Sagdic, O., Ozkan, Kubra, Ozkan, K., KARASU, Salih, Bayram, Yüksel   +6 more
core   +1 more source

The effect of continued and interval training with crocin consumption on BDNF and NGF gene expression in heart tissue of diabetic rats

Fiyz̤, 2019
Background: Diabetes in the long run causes damage to the heart tissue. The aim of the present study was to examine the effect of continued and interval training along with crocin consumption on BDNF and NGF gene expression in a heart tissue of diabetic ...
Seyed Hadi Razavi , Seyed Ali Hosseini , Masoud Nikbakht   +2 more
doaj  

Crocin attenuates osteoclastogenesis and enhances bone health by skewing the immunoporotic “Treg-Th17” cell axis in post-menopausal osteoporotic mice model

Phytomedicine Plus, 2022
Background: Crocin is a well-known carotenoid with established anti-inflammatory, anti-arthritic, anti-tumor, and antioxidant properties. Previous studies have also identified crocin as a potential drug candidate for osteoporosis treatment; however, the ...
Zaffar Azam, Leena Sapra, Asha Bhardwaj, Sumedha Yadav, Pradyumna K. Mishra, Prashant Shukla, Versha Sharma, Rupesh K. Srivastava   +7 more
doaj   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

Crocin reduces the inflammation response in rheumatoid arthritis

, 2017
This study is to determine the role and mechanism of crocin in rheumatoid arthritis (RA). Totally 60 Wistar SD rats were randomly divided into control group, RA model group, methotrexate group, crocin high dose, middle dose, and low dose groups.
Chao Jiang, Wenyong Zhu, Xiang Li
core   +1 more source

Role of Muscarinic Receptors in Hypoalgesia Induced by Crocin in Neuropathic Pain Rats

The Scientific World Journal, 2020
Objective. Crocin as an important constituent of saffron has antineuropathic pain properties; however, the exact mechanism of this effect is not known. The aim of this study was whether the hypoalgesic effect of crocin can be exerted through muscarinic ...
Hossein Ali Safakhah, Abbas Ali Vafaei, Azin Tavasoli, Simin Jafari, Ali Ghanbari   +4 more
doaj   +1 more source

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

Phytotherapy Research, EarlyView.
Schematic overview of the experimental models, therapeutic mechanisms, drug delivery systems, and clinical potential of natural polysaccharides in rheumatoid arthritis. ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis.
Luxin Li, Junnan Li, Guangzhi Li, Lili Huang, Tiantian Wen, Yanying Li, Yan Sun, Zhenqiang Liu, Qingshan Chen, Lili Zhang, Tiangang Lu, Ruiyan Wu, Haixue Kuang, Xiaochi Ma, Yan Liu   +14 more
wiley   +1 more source

Intestinal Metabolism of Crocin and a Pharmacokinetics and Pharmacodynamics Study in the Chronic Social Defeat Stress Mouse Model

Pharmaceuticals
Orally administered crocin rapidly and efficiently rescues depressive-like behaviors in depression models; however, crocin levels in the circulatory and central nervous systems are rather low.
Fan Xiao, Yulong Song, Guangji Wang, Jiye Aa   +3 more
doaj   +1 more source

Herbal Therapeutics in Osteoporosis: Mechanisms, Evidence, and Translational Potential

Phytotherapy Research, EarlyView.
Schematic overview of bone remodeling dysregulation in osteoporosis and the multi‐target protective role of herbal therapeutics. ABSTRACT Osteoporosis is a chronic bone disease marked by reduced density and increased fracture risk. Current treatments face limitations in safety, efficacy, and long‐term adherence, prompting interest in alternative ...
Elnaz Vafadar Moradi, Sina Vossoughinia, Zahra Yazdanpanah, Hossein Sobhani, Jalileh Jalali, Mahboobeh Ghasemzadeh Rahbardar   +5 more
wiley   +1 more source