Results 51 to 60 of about 3,702 (135)

Therapeutic Modulation of Inflammatory Signaling via Physalis Peruviana‐Derived Exosomes: A Targeted Effect on IKK/NFκB/STAT1

Molecular Nutrition &Food Research, Volume 70, Issue 7, 15 April 2026.
Exosomes derived from Physalis peruviana contain various bioactive compounds, such as RNAs, proteins, and secondary metabolites. These exosomes have been shown to contain different types of carotenoids that may have therapeutic properties. Physalis peruviana exosomes are capable of exhibiting anti‐inflammatory effects by influencing the IKK/NFκB/STAT1 ...
Cristian Martínez Fajardo, Lucía Morote, Susana López‐López, Alberto José López Jiménez, Oussama Ahrazem, Lourdes Gómez‐Gómez   +5 more
wiley   +1 more source

Evaluation of Saffron Quality Using Rapid Quantitative Inspection Technology with Near-Infrared Spectroscopy

Molecules
A predictive model utilizing near-infrared spectroscopy was developed to estimate the loss on drying, total contents of crocin I and crocin II, and picrocrocin content of saffron.
Ying Zhou, Han Zhang, Xiaohui Sheng, Rong Wang, Yao Yao, Qinglan Zhu, Ze Yi, Zhe Xu, Yi Wang, Cheng Zheng, Yu Tang   +10 more
doaj   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Crocin Treatment after Maternal Hypoxia Attenuates Spatial Memory Impairment and Expression of BACE1 and HIF-1α in Rat Offspring Brain

Basic and Clinical Neuroscience, 2020
Objective: Hypoxia via expression of Hypoxia Inducible Factor-1 (HIF-1) is an important and effective factor in the onset and progression of memory disorders such as Alzheimer Disease (AD).
Fahimeh Fahimi Truski, Zohreh Ghotbeddin, Mohammad Reza Tabandeh, Mahdi Pourmahdi Borujeni   +3 more
doaj  

Natural‐based antioxidants in cosmeceuticals: Extraction, bioavailability and skin ageing applications

International Journal of Cosmetic Science, Volume 48, Issue 2, Page 394-427, April 2026.
Natural antioxidants from plants, fruits, seeds and fungi combat ageing by neutralizing free radicals, boosting collagen and protecting against UV damage. Enhanced by green extraction and smart delivery systems, they offer powerful anti‐inflammatory and antimicrobial benefits.
Hossein Omidian, Arnavaz Akhzarmehr, Charise Dallazem Bertol   +2 more
wiley   +1 more source

Crocin ameliorates neuroinflammation and cognitive impairment in mice with Alzheimer's disease by activating PI3K/AKT pathway

Brain and Behavior
Background Crocin has a good prospect in the treatment of Alzheimer's disease (AD), but the mechanisms underlying its neuroprotective effects remain elusive.
Wenwen Su, Yanbo Wang, Sen Shao, Xiaojun Ye   +3 more
doaj   +1 more source

Study the Effect of Crocin on Avoidance Memory and Motor Activity Impairment Induced by Doxorubicin Administration in Adult Male Rats [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2017
Background: A lot of studies indicate that cancer chemotherapy drugs such as doxorubicin results in memory impairment. On the other hand, crocin as the chemical constituent isolated from the Saffron is effective on memory and motor enhancement.
Javad Sohrabi Asadabad, Zohreh Ghotbeddin, Mohammad Reza Tabandeh   +2 more
doaj  

Effects of Crocin on Brain Neurotrophins, Cognition, Balance and Pain in Toxic-Induced Demyelination Model

Acta Neurologica Taiwanica
Objective: The purpose of this study was to investigate the effects of Crocin on brain neuroterophins, cognition, sensory and motor dysfunction and compare to fingolimod effects in toxic-induced demyelination with Ethidium Bromide (EB) in female Wistar ...
Rouholah Fatemi, Hadi Fathi Moghaddam, Yaghoub Farbod, Roya Bigtashkhani   +3 more
doaj   +1 more source

Neuroprotective Effect of Crocin on Rats with Focal Cerebral Ischemia-Reperfusion Injury Based on TLR4/NF-κB Pathway

康复学报, 2022
ObjectiveTo observe the protective effect of crocin on neurons of rats with focal cerebral ischemia-reperfusion (FCIR) injury based on the toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) pathway, and to explore the possible mechanism of crocin in ...
LI Xiaolei, ZHU Haisheng, MA Ruijuan, HU Ke, FENG Lina, WANG Xudong   +5 more
doaj  

BT-474 Breast Cancer Cell Apoptosis Induced by Crocin, a Saffron Carotenoid

Basic & Clinical Cancer Research, 2019
Background: Saffron carotenoids have been known as powerful phytochemicals in breast cancer treatment. The purpose of this study was to investigate the anti-cancer properties of an important saffron carotenoid, crocin, on BT-474 which is a known HER2 ...
Nassim Faridi, Hamid Heidarzadeh, Mohammad Ali Mohagheghi, S. Zahra Bathaie   +3 more
doaj   +1 more source