Results 71 to 80 of about 5,332 (163)

Knee Osteoarthritis Therapy Targeting NLRP3 Inflammasome: Progress From Mechanism to Application

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Objective This paper briefly reviews the structure, function, and activation mechanism of the NLRP3 inflammasome and its molecular role in the pathogenesis of knee osteoarthritis (KOA), and explores the potential value of traditional Chinese medicine (TCM) in treating KOA by modulating NLRP3 inflammasome activity.
Wenguang Chen, Baoxiu Yi, Zhang Wang, Cong Yu, Ziru Li, Zenan Wu, Ensi Hong   +6 more
wiley   +1 more source

Optimizing the Anti‐Inflammatory Efficacy of Pakistani Spice Blends: A Farm‐to‐Fork Analysis of Phytochemical Synergy and Processing Stability

eFood, Volume 7, Issue 4, August 2026.
This review aims to evaluate the anti‐inflammatory potential of these spice blends, emphasizing their synergistic mechanisms, and to investigate how cultivation practices, post‐harvest processing, and environmental stressors shape their medicinal efficacy. By addressing this gap, it seeks to provide a comprehensive framework for integrating traditional
Qudrat Ullah, Waqas Haider, Farhang Hameed Awlqadr, Ahmed Bilal, Muhammad Tayyab Arshad, Emmanuel Laryea   +5 more
wiley   +1 more source

Crocin, a plant-derived carotenoid, modulates microglial reactivity

, 2017
Microglia activation plays an important role in immune responses in the CNS including the retina. Crocin, a plant-derived carotenoid, has been reported to possess anti-inflammatory, anti-apoptotic and anti-oxidative capacity in models of retinal damage ...
Katharina Dannhausen, Khalid Rashid, Thomas Langmann, Alexander Aslanidis, Charlotte Bresgen, Mücella Arikan Yorgun   +5 more
core   +1 more source

Enhancement of Morpho‐Physiological, Physiological, and Antioxidant Capacity of Saffron (Crocus sativus L.) Under Water Deficit Using ZnO Nanoparticles and Magnesium Sulfate: Implications for Saffron Yield

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
ZnO nanoparticles and MgSO4 synergistically alleviated drought‐induced damage in saffron. Foliar application improved relative water content and antioxidant enzyme activity. Photosynthetic performance and membrane stability were enhanced under water deficit. Moderate drought combined with ZnO‐NPs and MgSO4 maximized saffron productivity. ABSTRACT Water
Laila Turki Fadala, Seham Zaben, Ekhlas Meteab Ahmed Marir, Heidar Meftahizade   +3 more
wiley   +1 more source

Evaluation of Saffron Quality Using Rapid Quantitative Inspection Technology with Near-Infrared Spectroscopy

Molecules
A predictive model utilizing near-infrared spectroscopy was developed to estimate the loss on drying, total contents of crocin I and crocin II, and picrocrocin content of saffron.
Ying Zhou, Han Zhang, Xiaohui Sheng, Rong Wang, Yao Yao, Qinglan Zhu, Ze Yi, Zhe Xu, Yi Wang, Cheng Zheng, Yu Tang   +10 more
doaj   +1 more source

SIRT Family: Biological Functions and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong   +9 more
wiley   +1 more source

Crocin Treatment after Maternal Hypoxia Attenuates Spatial Memory Impairment and Expression of BACE1 and HIF-1α in Rat Offspring Brain

Basic and Clinical Neuroscience, 2020
Objective: Hypoxia via expression of Hypoxia Inducible Factor-1 (HIF-1) is an important and effective factor in the onset and progression of memory disorders such as Alzheimer Disease (AD).
Fahimeh Fahimi Truski, Zohreh Ghotbeddin, Mohammad Reza Tabandeh, Mahdi Pourmahdi Borujeni   +3 more
doaj  

Multi‐Induction Strategies in Crops: Mechanisms, Synergistic Effects, and Sustainable Applications for Enhanced Secondary Metabolite Production

Food Frontiers, Volume 7, Issue 4, July 2026.
This review analyzes single/combined abiotic (light, water, nutrients, hormones) and biotic (microbes, yeast) elicitors regulating signaling, gene expression, and metabolism to boost plant secondary metabolites. It highlights synergistic multielicitor strategies for crop quality and functional foods, while critically addressing current limitations and ...
Yifei Sun, Daoyan Xiao, Xingyue Li, Zhaofei Wang, Maoqin Xia, Chao Song, Hong‐Lei Li   +6 more
wiley   +1 more source

Crocin ameliorates neuroinflammation and cognitive impairment in mice with Alzheimer's disease by activating PI3K/AKT pathway

Brain and Behavior
Background Crocin has a good prospect in the treatment of Alzheimer's disease (AD), but the mechanisms underlying its neuroprotective effects remain elusive.
Wenwen Su, Yanbo Wang, Sen Shao, Xiaojun Ye   +3 more
doaj   +1 more source

Study the Effect of Crocin on Avoidance Memory and Motor Activity Impairment Induced by Doxorubicin Administration in Adult Male Rats [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2017
Background: A lot of studies indicate that cancer chemotherapy drugs such as doxorubicin results in memory impairment. On the other hand, crocin as the chemical constituent isolated from the Saffron is effective on memory and motor enhancement.
Javad Sohrabi Asadabad, Zohreh Ghotbeddin, Mohammad Reza Tabandeh   +2 more
doaj