Results 51 to 60 of about 9,113,589 (351)

Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial.

Gastroenterology, 2006
BACKGROUND & AIMS Tumor necrosis factor blockade has been shown to be an effective treatment strategy in Crohn's disease (CD). Adalimumab is a human immunoglobulin G1 (IgG(1)) monoclonal antibody targeting tumor necrosis factor (TNF).
S. Hanauer, W. Sandborn, P. Rutgeerts, R. Fedorak, M. Lukáš, D. Macintosh, R. Panaccione, D. Wolf, P. Pollack   +8 more
semanticscholar   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

3rd European Evidence-based Consensus on the Diagnosis and Management of Crohn's Disease 2016: Part 2: Surgical Management and Special Situations.

Journal of Crohn's & Colitis, 2017
This paper is the second in a series of two publications relating to the European Crohn's and Colitis Organisation [ECCO] evidence-based consensus on the diagnosis and management of Crohn's disease [CD] and concerns the surgical management of CD as well ...
P. Gionchetti, A. Dignass, S. Danese, Fernando José Magro Dias, G. Rogler, P. L. Lakatos, M. Adamina, S. Ardizzone, C. Buskens, S. Sebastian, S. Laureti, G. Sampietro, B. Vucelić, C. J. van der Woude, M. Barreiro-de Acosta, C. Maaser, F. Portela, S. Vavricka, F. Gomollón   +18 more
semanticscholar   +1 more source

Colon‐Targeted Natural Polysaccharide‐Berberine Armored Hydrogel for the Treatment of Colitis

Advanced Healthcare Materials, EarlyView.
In this research, a novel hydrogel system targeting the colon is developed, incorporating Rhubarb polysaccharides and berberine‐loaded dendrimer. This hydrogel, forms through intermolecular hydrogen bonding and electrostatic interactions, accumulates in colonic tissues, effectively alleviating pathological immune hyperactivation while modulating gut ...
Miao Guo, Bo Li, Hongyi Li, Yi Chen, Qin Yuan, Mingju Shui, Hefeng Zhou, Wei Hao, Shengpeng Wang   +8 more
wiley   +1 more source

A Short-Term Study of Chimeric Monoclonal Antibody cA2 to Tumor Necrosis Factor α for Crohn's Disease

, 1997
Background Studies in animals and an open-label trial have suggested a role for antibodies to tumor necrosis factor α, specifically chimeric monoclonal antibody cA2, in the treatment of Crohn's disease.
S. Targan, S. Hanauer, S. V. van Deventer, L. Mayer, D. Present, T. Braakman, K. DeWoody, T. Schaible, P. Rutgeerts   +8 more
semanticscholar   +1 more source

ECCO Guidelines on Therapeutics in Crohn's Disease: medical treatment.

Journal of Crohn's & Colitis, 2019
This article is the second in a series of two publications relating to the European Crohn’s and Colitis Organisation [ECCO] evidence-based consensus on the management of Crohn’s disease.
Joana Torres, S. Bonovas, Glen Doherty, T. Kucharzik, J. Gisbert, T. Raine, M. Adamina, A. Armuzzi, Oliver Bachmann, P. Bager, L. Biancone, B. Bokemeyer, P. Bossuyt, J. Burisch, Paul Collins, A. El‐Hussuna, P. Ellul, Cornelia Frei-Lanter, F. Furfaro, C. Gingert, P. Gionchetti, F. Gomollón, Marien González-Lorenzo, Hannah Gordon, T. Hlavatý, P. Juillerat, Konstantinos H Katsanos, U. Kopylov, E. Krustiņš, T. Lytras, C. Maaser, F. Magro, John Kenneth Marshall, P. Myrelid, Gianluca Pellino, I. Rosa, J. Sabino, E. Savarino, A. Spinelli, Laurents P. S. Stassen, Mathieu Uzzan, S. Vavricka, B. Verstockt, J. Warusavitarne, O. Zmora, G. Fiorino   +45 more
semanticscholar   +1 more source

A Wireless Soft Optical Blood Sensor for Colonoscopy

Advanced Sensor Research, EarlyView.
This works presents an “add‐on” wireless soft optical blood sensor for the traditional colonoscopy. It can reliably detect bleeding behind the colonoscope's distal tip camera via optical absorption, without optical fibers, and wirelessly transmit data to the processor.
Kamin Palkawong‐Na‐Ayuddhaya, Arincheyan Gerald, Addison Chu, Johann Pang, Arnav Mankad, Hiroyuki Aihara, Sheila Russo   +6 more
wiley   +1 more source

Familial Prevalence of Inflammatory Bowel Disease in Northern Alberta

Canadian Journal of Gastroenterology, 1990
Previous studies have reported a high prevalence of inflammatory bowel disease among the relatives, and especially siblings, of patients with Crohn's disease or ulcerative colitis.
BR Pinchbeck, J Kirdeikis, ABR Thomson
doaj   +1 more source

Carrier‐Free Nanocapsule with Dual‐Target Capacity for Synergistically Restoring Inflammatory Microenvironment and Microbiota Dysbiosis in Colitis

Advanced Science, EarlyView.
This manuscript presents a carrier‐free nanomedicine PCNPs@PEG‐Man with dual‐targeting for IBD. It resists harsh intestinal conditions, reduces oxidative stress, enhances drug uptake and retention, modulates inflammation, and reshapes gut microbiota, offering a safe and effective IBD therapy.
Yingjie Chen, Yuhan Gao, Kaiyuan Huo, Zhaofan Jin, Wenchao Wang, Xingjie Zan, Yanlong Liu, Limeng Zhu, Jianfeng Yang   +8 more
wiley   +1 more source

What constitutes failure of medical therapy in the changing landscape of Crohn's disease?

Laparoscopic, Endoscopic and Robotic Surgery, 2022
The management of Crohn's disease has evolved rapidly in the era of immunomodulators and biologicals. Despite this, a significant proportion of patients with Crohn's disease ultimately require surgical management.
Nguyen Huynh, Henry Wang, Kar Yin Fok, James Wei Tatt Toh   +3 more
doaj