Results 41 to 50 of about 61,456 (351)

Successful treatment of hidradenitis suppurativa in the setting of Crohn disease with combination adalimumab and ustekinumab [PDF]

, 2019
Herein we report the combination of adalimumab and ustekinumab to successfully treat a 39-year-old woman who presented for evaluation of hidradenitis suppurativa in the setting of Crohn disease of both the small and large intestine.
Cline, Abigail, Pichardo, Rita O
core  

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Pulmonary Delivery of siRNA Anti‐TNFα‐loaded Lipid Nanoparticles for Rapid Recovery in Murine Acute Lung Injury

Advanced Healthcare Materials, EarlyView.
In a murine model of acute lung injury, pulmonary administration of lipid nanoparticles carrying TNFα siRNA enables targeted delivery to immune cells. The study emphasises the importance of optimizing LNP distribution and delivery timing to improve therapeutic outcomes and develop emergency therapies for lung hyperinflammation.
Qinglin Wang, Jihana Achour, Laila Emam, Younes Louaguenouni, Catherine Cailleau, Françoise Mercier‐Nomé, Séverine Domenichini, Claudine Delomenie, Sezen Gul, Juliette Vergnaud, Nicolas Tsapis, Arnaud Mansart, Djillali Annane, Francois Fay, Elias Fattal   +14 more
wiley   +1 more source

Oral Crohn′s disease without intestinal manifestations

Journal of Pharmacy and Bioallied Sciences, 2012
Crohn′s disease is a granulomatous inflammatory bowel disease and was described in 1932 as a chronic granulomatous disorder of the terminal ileum and is now considered a distinct member of the inflammatory bowel disease family.
Gingisetty Harikishan, Nagate Raghavendra Reddy, Harikrishnan Prasad, Subappa Anitha   +3 more
doaj   +1 more source

Histopathology of the gut in rheumatic diseases [PDF]

, 2018
The gastrointestinal tract regulates the trafficking of macromolecules between the environment and the host through an epithelial barrier mechanism and is an important part of the immune system controlling the equilibrium between tolerance and immunity ...
Ciccia F., Ferrante A., Guggino G., Macaluso F., Rizzo A.   +4 more
core   +1 more source

Myeloperoxidase Luminol Reaction – A Novel Faecal Assay for Predicting Colonoscopy Findings in Patients with Ulcerative Colitis: A Pilot Cross‐Sectional Clinical Study

Advanced Healthcare Materials, EarlyView.
Can luminol detect faecal inflammation? This study explores the development and optimisation of a rapid novel assay ‐ Myeloperoxidase Luminol Reaction (MPOLR) for the detection of faecal myeloperoxidase activity. This simple and rapid luminol‐based approach competes with clinically validated faecal biomarkers in predicting endoscopic findings in ...
Viraj Kariyawasam, Taylor Davis, Mark Ghali, David Tejcek, Thomas R O'Neil, Ella Verley, Matthew Griffiths, Miguel Campos, Ingrid Bonney, Andrew C. Bulmer, Yogambha Ramaswamy, Nikola Mitrev, Crispin Corte, Paul K. Witting, Belal Chami   +14 more
wiley   +1 more source

A Complicated Thread: Abdominal Actinomycosis in a Young Woman with Crohn Disease

Case Reports in Gastroenterology, 2017
Crohn disease is a chronic inflammatory condition that primarily affects the gastrointestinal tract. Typical manifestations include fever, weight loss, fatigue, and abdominal pain, and abdominal abscesses and fistulae are frequent complications ...
Ari Nahum, Gregory Filice, Ashish Malhotra   +2 more
doaj   +1 more source

Wireless Capsule Device for Targeted and Safe Tissue Biopsy with Integrated Sensing

Advanced Materials Technologies, EarlyView.
This work presents a capsule device featuring a novel magnetically controlled biopsy mechanism for enhanced safety. The biopsy unit integrates a foldable linkage with dual magnets, creating a magnetic attraction–based safeguard, preventing unintended activation during locomotion. A flexible sensor provides real‐time penetration displacement sensing for
Kiyoung Kim, Jacob Katona, Jiale Chu, Boyang Xiao, Rishi Naik, Xiaoguang Dong   +5 more
wiley   +1 more source

Oropharyngeal Crohn’s disease

Clinical and Experimental Gastroenterology, 2008
Rachid Mohamed, Robert Schultz, Richard N FedorakDivision of Gastroenterology, University of Alberta, Edmonton, AlbertaAbstract: Crohn’s disease is a chronic inflammatory disease that can affect any part of the gastrointestinal tract ...
Rachid Mohamed, Robert Schultz, Richard N Fedorak   +2 more
doaj