Interpretable histopathology-based prediction of disease relevant features in Inflammatory Bowel Disease biopsies using weakly-supervised deep learning [PDF]
arXiv, 2023 Crohn's Disease (CD) and Ulcerative Colitis (UC) are the two main Inflammatory Bowel Disease (IBD) types. We developed deep learning models to identify histological disease features for both CD and UC using only endoscopic labels. We explored fine-tuning and end-to-end training of two state-of-the-art self-supervised models for predicting three ...
arxiv
The PRECiSE 2 trial of certolizumab pegol, a new PEGylated anti-TNF agent, in the treatment of Crohn’s disease: An interview with David A Schwartz, 13 June 2007 [PDF]
, 2008 David A SchwartzVanderbilt University Medical Center, Nashville, TN, USAContext: Certolizumab pegol (CDP 870) is a new anti-tumor necrosis factor (TNF) therapy currently in development for the treatment of Crohn’s disease, rheumatoid arthritis,
Schwartz, David A
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Research gaps in diet and nutrition in inflammatory bowel disease. A topical review by D-ECCO Working Group (Dietitians of ECCO) [PDF]
, 2017 Although the current doctrine of IBD pathogenesis proposes an interaction between environmental factors with gut microbiota in genetically-susceptible individuals, dietary exposures have attracted recent interest and are, at least in part, likely to ...
Allan, Philip +14 more
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Automatic Detection of Bowel Disease with Residual Networks [PDF]
arXiv, 2019 Crohn's disease, one of two inflammatory bowel diseases (IBD), affects 200,000 people in the UK alone, or roughly one in every 500. We explore the feasibility of deep learning algorithms for identification of terminal ileal Crohn's disease in Magnetic Resonance Enterography images on a small dataset.
arxiv
The contribution of OCTN1/2 variants within the IBD5 locus to disease susceptibility and severity in Crohn's disease [PDF]
, 2005 Background and Aims: Recent data suggest that polymorphisms in the organic cation transporter (OCTN) genes OCTN1 (SLC22A4) and OCTN2 (SLC22A5) represent disease-causing mutations within the IBD5 locus (chromosome 5q31).
Anderson, Norman +8 more
core +1 more source
Integrated analysis of variants and pathways in genome-wide association studies using polygenic models of disease [PDF]
arXiv, 2012 Many common diseases are highly polygenic, modulated by a large number genetic factors with small effects on susceptibility to disease. These small effects are difficult to map reliably in genetic association studies. To address this problem, researchers have developed methods that aggregate information over sets of related genes, such as biological ...
arxiv
In Search of Newer Targets for IBD: A Systems and a Network Medicine Approach [PDF]
arXiv, 2020 Introduction: Crohn's disease and ulcerative colitis, both under the umbrella of inflammatory bowel diseases (IBD), involve many distinct molecular processes. The difference in their molecular processes is studied by using the different genes involved in each disease, and it is explored further for drug targeting and drug repurposing.
arxiv
Are CAMs Safe and Effective in Improving Symptoms of Adult Patients Over the Age of 18 With Active Crohn Disease? [PDF]
, 2017 Objective: The objective of this selective EBM review is to determine whether or not complimentary and alternative medicines are safe and effective in improving symptoms of adult patients over the age of 18 with active Crohn disease.
Pellerito, Amy
core +1 more source
Telocytes in Crohn's disease [PDF]
Journal of Cellular and Molecular Medicine, 2013 AbstractCrohn's disease (CD) is a relapsing chronic inflammatory disorder that may involve all the gastrointestinal tract with a prevalence of terminal ileum. Intestinal lesions have a characteristic discontinuous and segmental distribution and may affect all layers of the gut wall.
A. F. Milia +7 more
openaire +4 more sources
Crohn\u27s Disease: Management, Emerging Therapies and the Role of the Pharmacist [PDF]
, 2019 Crohn\u27s disease is a relapsing-remitting disorder of the gastrointestinal tract caused by a mixture of genetic and environmental factors. Pharmacologic treatment of Crohn\u27s disease is patient-specific, and regimens vary widely between individuals ...
Kneuss, Tiffany +4 more
core +1 more source