From metagenomic data to personalized computational microbiotas: Predicting dietary supplements for Crohn's disease [PDF]
arXiv, 2017 Crohn's disease (CD) is associated with an ecological imbalance of the intestinal microbiota, consisting of hundreds of species. The underlying complexity as well as individual differences between patients contributes to the difficulty to define a standardized treatment.
arxiv
Crohn’s disease associated with pachydermoperiostosis [PDF]
, 1999 Pachydermoperiostosis is a rare hereditary syndrome characterized by finger clubbing, periosteal change, pachydermia and autonomic nervous system symptoms such as facial flushing and hy perhidrosis.
김원호
core
Ensemble Prediction of Time to Event Outcomes with Competing Risks: A Case Study of Surgical Complications in Crohn's Disease [PDF]
arXiv, 2019 We develop a novel algorithm to predict the occurrence of major abdominal surgery within 5 years following Crohn's disease diagnosis using a panel of 29 baseline covariates from the Swedish population registers. We model pseudo-observations based on the Aalen-Johansen estimator of the cause-specific cumulative incidence with an ensemble of modern ...
arxiv
Narrowing the gap on heritability of common disease by direct estimation in case-control GWAS [PDF]
arXiv, 2013 One of the major developments in recent years in the search for missing heritability of human phenotypes is the adoption of linear mixed-effects models (LMMs) to estimate heritability due to genetic variants which are not significantly associated with the phenotype.
arxiv
Mechanisms of Intestinal Epithelial Barrier Dysfunction by Adherent-Invasive Escherichia coli. [PDF]
, 2016 Pathobiont expansion, such as that of adherent-invasive Escherichia coli (AIEC), is an emerging factor associated with inflammatory bowel disease. The intestinal epithelial barrier is the first line of defense against these pathogens.
McCole, Declan F, Shawki, Ali
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Clinical and Translational Gastroenterology, 2017 Fistulas still represent one of the most important complications in patients with Crohn's disease (CD). At least one third of CD patients suffer from fistulas during their disease course and amongst them longstanding remission of complex fistulas occurs only in about one third. So far, fistula pathogenesis is only partially understood.
Scharl, Michael +2 more
openaire +3 more sources
Detecting and managing small bowel Crohn’s disease – capsule endoscopy becoming a first line diagnostic method? [PDF]
, 2011 Small bowel endoscopy is crucial for diagnosing small bowel Crohn’s disease, and capsule endoscopy is complemented by balloon-assisted enteroscopy to take biopsies and by magnetic resonance imaging to visualize enteral and extra-intestinal involvement ...
Albert, Jörg Gerhard +1 more
core +1 more source
Superpixels Based Segmentation and SVM Based Classification Method to Distinguish Five Diseases from Normal Regions in Wireless Capsule Endoscopy [PDF]
arXiv, 2017 Wireless Capsule Endoscopy (WCE) is relatively a new technology to examine the entire GI trace. During an examination, it captures more than 55,000 frames. Reviewing all these images is time-consuming and prone to human error. It has been a challenge to develop intelligent methods assisting physicians to review the frames.
arxiv
, 2018 Crohn’s disease is a progressive and systemic autoimmune disease that causes inflammation to any part of the gastrointestinal tract. The inflammation causes some of the clinical manifestations of crohn’s disease such as abdominal pain, diarrhea ...
Hubena, Mergithu
core +1 more source
Azathioprine and 6-mercaptopurine for maintenance of surgically-induced remission in Crohn’s disease [PDF]
, 2014 Background Crohn’s disease (CD) is a chronic relapsing inflammatory condition. Many patients fail to achieve remission with medical management and require surgical interventions.
Angelberger +41 more
core +1 more source