Results 51 to 60 of about 1,050,820 (318)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Exogenous Regulators Enhance Physiological Recovery and Yield Compensation in Maize Following Mechanical Leaf Damage

Agronomy
To elucidate how exogenous regulators mitigate the impact of mechanical leaf damage on maize, field experiments were conducted on two sowing dates (S1, S2) using two cultivars (XY335, ZD958). Severe leaf damage at the six-leaf stage significantly reduced
Aonan Jiang, Dahong Bian, Xushuang Chen, Qifan Yang, Zhongbo Wei, Xiong Du, Zhen Gao, Guangzhou Liu, Yanhong Cui   +8 more
doaj   +1 more source

Forage cuts as a by-product in organic seed production [PDF]

, 2002
A major problem in organic grass seed production on arable farms is to provide for a sufficient nitrogen supply. A nitrogen-fixing crop may be able to cover the nitrogen requirement - wholly or partly.
Boelt, B., Deleuran, L.C.
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Growth and competition model for organic weed control [PDF]

, 2002
There is a more detailed Executive Summary at the top of the attached document, which is the final report for Defra Project OF0177. The project aimed to examine the organic extension of a simple mechanistically-based growth and competition model ...
Anon
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Supplemental irrigation mitigates yield loss of maize through reducing canopy temperature under heat stress

Agricultural Water Management
Due to global warming, high temperature stress severely impacts maize growth and development, especially during the early filling stage. Supplemental irrigation is an effective measure to mitigate high temperature stress in maize. However, the underlying
Huajian Jian, Zhen Gao, Yingying Guo, Xinyan Xu, Xiaoyu Li, Meijia Yu, Guangzhou Liu, Dahong Bian, Yanhong Cui, Xiong Du   +9 more
doaj   +1 more source

Crop coefficients, growth rates and quality of cool-season turfgrasses [PDF]

, 2015
Determination of crop coefficients (Kc), the ratio between actual (ETa) and reference evapotranspiration (ET0), is necessary to schedule irrigation. Our objective was to determine Kc, turf quality and growth rate under daily irrigation to field capacity (
Allen, Allen, Aronsen, Aronsen, Bigelow, Biran, Bremer, Brown, Carrow, DaCosta, Ebdon, Espevig, Espevig, Feldhake, Feldhake, Feldhake, Fry, Fry, Hughes, Kim, Knox, Orick, Penman, Qian, Richardson, Riley, Riley, Rodríguez-Díaz, Sass, Shearman, Strandberg   +30 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source