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Cross-presentation is getting DNGRous
Nature Immunology, 2021Following internalization of an actin-bearing ligand, the C-type lectin receptor DNGR-1 promotes phagosome rupture, allowing antigens to access the cytosol and be processed through the MHC-I pathway.
Remi Hatinguais, Gordon D. Brown
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Cross-presentation by the others
Seminars in Immunology, 2023The critical role of conventional dendritic cells in physiological cross-priming of immune responses to tumors and pathogens is widely documented and beyond doubt. However, there is ample evidence that a wide range of other cell types can also acquire the capacity to cross-present.
François-Xavier, Mauvais +1 more
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Current Concepts of Antigen Cross-Presentation [PDF]
Frontiers in Immunology, 2018 Dendritic cells have the ability to efficiently present internalized antigens on major histocompatibility complex (MHC) I molecules. This process is termed cross-presentation and is important role in the generation of an immune response against viruses and tumors, after vaccinations or in the induction of immune tolerance.
Maria Embgenbroich, Sven Burgdorf
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Engineering cross-presentation in vivo
Expert Opinion on Biological Therapy, 2003Apoptotic bodies deliver antigens (Ags) to the cross-presentation pathways of dendritic cells (DCs), where their presentation has been associated with both the maintenance of tolerance as well as the induction of protective immunity. The manner in which apoptotic bodies are generated, their abundance in relation to local DCs, and the milieu in which ...
Michael A, Chattergoon +2 more
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Cross-presentation of Exogenous Antigens
Transfusion Clinique et Biologique, 2019Presentation of exogenous antigens loaded on major histocompatibility complex class I molecules by antigen presenting cells, termed cross-presentation, is essential for the induction of CD8+ T cells and is performed mainly by specialized dendritic cell subsets.
B, Li, L, Hu
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Pathways for antigen cross presentation
Springer Seminars in Immunopathology, 2004Dendritic cells (DCs) have the unique ability to capture cellular tissue antigens, and to present them on MHC class I molecules to antigen-specific CD8(+) T lymphocytes after migration to the draining lymph nodes. This process, called "cross presentation" can lead either to the tolerization or activation of antigen-specific CD8(+) T cells.
Guermonprez, P, Amigorena, S
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Coupling and cross-presentation
Nature, 2005Studies of cultured cells have revealed how the immune system may use intercellular pores to convey information that is important in initiating antiviral responses and in limiting the spread of infections.
William R. Heath, Francis R. Carbone
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An invariant road to cross-presentation
Nature Immunology, 2012The invariant chain CD74 prevents the loading of peptides derived from endogenously synthesized proteins onto major histocompatibility complex (MHC) class II molecules in the endoplasmic reticulum. CD74 is now shown to serve a similar function for some MHC class I molecules.
Fei, Duan, Pramod K, Srivastava
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CROSS-PRESENTATION, DENDRITICCELLS, TOLERANCE ANDIMMUNITY
Annual Review of Immunology, 2001This review examines the role of cross-presentation in tolerance and immunity. We discuss (a) the antigenic requirements for cross-presentation, (b) the phenotype of the antigen presenting cell (APC), (c) the cellular interactions and molecular signals involved in cross-priming, and (d) the factors that direct the immune system toward tolerance or ...
William Heath
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The show and tell of cross-presentation
2023Cross-presentation is the culmination of complex subcellular processes that allow the processing of exogenous proteins and the presentation of resultant peptides on major histocompatibility class I (MHC-I) molecules to CD8 T cells. Dendritic cells (DCs) are a cell type that uniquely specializes in cross-presentation, mainly in the context of viral or ...
J Magarian, Blander +3 more
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